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Nervous about the exam and can't remember the knowledge points? Zhong Yi's team at Tsinghua University revealed the neurobiological mechanism of emotional state-mediated memory retrieval
Time of Update: 2023-01-06
Adult newborn granule cells confer emotionalstate–dependent adaptability in memory retrievalThe images in the article are from referencesClick on the blue word to follow usAnimals can flexibly extract relevant memories according to the current state, different emotional experiences have obvious regulatory effects on the memory process, acute stress can hinder memory retrieval, and rich environment will enhance memory acquisition, but there is still little understanding of how the hippocampal brain region integrates different emotional experiences into the memory process.
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Nervous about the exam and can't remember the knowledge points? Zhong Yi's team at Tsinghua University revealed the neurobiological mechanism of emotional state-mediated memory retrieval
Time of Update: 2023-01-06
Adult newborn granule cells confer emotionalstate–dependent adaptability in memory retrievalThe images in the article are from referencesClick on the blue word to follow usAnimals can flexibly extract relevant memories according to the current state, different emotional experiences have obvious regulatory effects on the memory process, acute stress can hinder memory retrieval, and rich environment will enhance memory acquisition, but there is still little understanding of how the hippocampal brain region integrates different emotional experiences into the memory process.
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Neuron Mo Wei's team revealed that microglia sense amyloid plaque hardness through Piezo1 to limit the progression of Alzheimer's disease
Time of Update: 2023-01-06
Alzheimer's disease (AD) is the most common neurodegenerative disease in older adults and is characterized by progressive cognitive impairment and behavioral impairment. The two typical pathological f
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Neuron Mo Wei's team revealed that microglia sense amyloid plaque hardness through Piezo1 to limit the progression of Alzheimer's disease
Time of Update: 2023-01-06
Alzheimer's disease (AD) is the most common neurodegenerative disease in older adults and is characterized by progressive cognitive impairment and behavioral impairment. The two typical pathological f
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Microglia sense amyloid plaque hardness through Piezo1 to limit Alzheimer's disease progression Cell Press spoke to scientists
Time of Update: 2023-01-06
Life SciencesLife scienceRecently, Professor Mo Wei's team of Xiamen University published the research results entitled "Microglial Piezo1 senses Aβ fibrils stiffness to restrict Alzheimer's disease"
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The brain cells in the petri dish also play the electronic batting game Neuron
Time of Update: 2023-01-06
Image credit: Cortical LabsSOURCE: CORTICAL LABSTranslated by Shilin ShuEdited by Wei XiaoA team of scientists led by scientists in Melbourne, Australia, has demonstrated for the first time that 800,000 brain cells living in a petri dish can perform goal-directed tasks — in this case, playing the simple tennis-like computer game "Pong.
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The brain cells in the petri dish also play the electronic batting game Neuron
Time of Update: 2023-01-06
Image credit: Cortical LabsSOURCE: CORTICAL LABSTranslated by Shilin ShuEdited by Wei XiaoA team of scientists led by scientists in Melbourne, Australia, has demonstrated for the first time that 800,000 brain cells living in a petri dish can perform goal-directed tasks — in this case, playing the simple tennis-like computer game "Pong.
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After publishing acupuncture research in Nature and revealing the existence of acupuncture points, Harvard full professor Ma Qiufu returned to China and joined Westlake University
Time of Update: 2023-01-06
In October 2021, Ma Qiufu's team and others published a paper in Nature to achieve a historic breakthrough in acupuncture research, which showed a class of PROKR2-Cre-labeled dorsal root ganglia (DRG) Sensory neurons are essential for low-intensity acupuncture stimulation to activate the vagus-adrenal anti-inflammatory pathway.
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Nature sub-issue 1 published 2 articles: The new oncolytic virus is equipped with dual antibodies to treat glioma; Inventory of the "arming" strategy of multiple oncolytic viruses
Time of Update: 2023-01-06
Official website of each company——List of recent popular events——November 23, Key Elements of Quality Control for mRNA VaccinesNovember 19, 2022 / eMedClub News / -- November 17, 2022, Nature Cancer In an article titled "An armed oncolytic virus for GBM destruction," an oncolytic herpes simplex virus (oHSV) that carries a bispecific EGFR-CCL5 antibody fusion protein that activates innate and adaptive anti-tumor immune responses has shown extremely high efficacy in preclinical models of glioblastoma (GBM).
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Nature sub-issue 1 published 2 articles: The new oncolytic virus is equipped with dual antibodies to treat glioma; Inventory of the "arming" strategy of multiple oncolytic viruses
Time of Update: 2023-01-06
Official website of each company——List of recent popular events——November 23, Key Elements of Quality Control for mRNA VaccinesNovember 19, 2022 / eMedClub News / -- November 17, 2022, Nature Cancer In an article titled "An armed oncolytic virus for GBM destruction," an oncolytic herpes simplex virus (oHSV) that carries a bispecific EGFR-CCL5 antibody fusion protein that activates innate and adaptive anti-tumor immune responses has shown extremely high efficacy in preclinical models of glioblastoma (GBM).
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"Nature" blockbuster: MIT cow Cai Lihui's team found for the first time that ApoE4 causes cholesterol to be deposited inside oligodendrocytes, intervening in cholesterol or becoming a new treatment for Alzheimer's disease
Time of Update: 2023-01-06
*For medical professionals onlyExcited heart, trembling hands, my idol Teacher Cai, sent "Nature" again!A few days ago, two phase 3 clinical trials of gantenerumab announced that they did not reach th
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Can cerebral infarction in elderly patients be thrombolysis? See what the top issue has to say!
Time of Update: 2023-01-06
A 2014 review published in Lancet in nine clinical trials (6756 patients with ischemic stroke treated with alteplase) (Figure 2) showed that people over 80 years of age still benefit from intravenous thrombolysis with alteplase within 3.
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Is there also benefit in patients with seronegative myasthenia gravis? One of the 2022 AANEM Essentials Hot Review Series
Time of Update: 2023-01-06
GuideMG (myasthenia gravis) is an antibody-mediated autoimmune disease, acetylcholine receptor (AChR) antibodies are the most common pathogenic antibodies, AChR antibodies are present in about 85% of
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Winning Zai Future Elite Club, MG Youth Original Scientific Research Forum 2022 Summit Wonderful Review
Time of Update: 2023-01-06
In the past 10 years, research results in the field of myasthenia gravis (MG) in China have emerged, and the number of papers published has ranked among the top in the world. In order to further encou
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Nature Medicine: Cognition is normal, but Aβ and Tau PET are both positive, and the risk of cognitive decline soars 18 times in the next 3-5 years!
Time of Update: 2023-01-06
The study found that the group with both Aβ and tau positive (A+T+) but cognitively normal after PET verification had a 19-fold increase in the risk of progressing to MCI within 3~5 years compared with the negative group (A-T-)++-[1]!
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NEJM sub-journal: Improve the cognition of people with mild cognitive impairment, crossword puzzles are very good!
Time of Update: 2023-01-06
In addition, in subjects with late MCI, the change in ADAS-Cog score was manifested as cognitive decline in the computer game group and improvement in cognitive function in the crossword group at week 12 (LS mean difference: -1.
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The risk of stroke in young people has risen dramatically! JAMA is here to give you a wake-up call
Time of Update: 2023-01-06
conclusionUsing data from the Oxford Vascular Study, the researchers explored whether stroke rates changed between 2002 and older people in young and old people, which included 94,567 people registered at GP clinics in Oxfordshire.
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Hu Gang's team revealed that microglia promote toxic astrocytes formation and induce depression-like behavior
Time of Update: 2023-01-06
1038/s41586-022-05328-2The images in the article are from referencesFigure 1: Increased activation of hippocampal neurotoxic astrocytes after stress2NLRP3 regulates the increase of astrocytes in the hippocampusGiven that NLRP3 regulates phenotypic transitions in A1 astrocytes and increases hippocampal NLRP3 levels after CMS, they constructed NLRP3 total knockout mice and found that knocking out NLRP3 was able to attenuate CMS-induced depression-like behavioral disorders, reduce the number of hippocampal A1 astrocytes, and attenuate synaptic protein loss.
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JAMA Sub-issue: Discover blood markers to evaluate the efficacy of Alzheimer's disease drugs!
Time of Update: 2023-01-06
At baseline, plasma pTau217 levels in AD patients were significantly positively correlated with brain amyloid plaques and Tau protein deposition on Aβ and Tau PET imagingNext, the researchers analyzed changes in plasma biomarkers in AD patients after Donanemab treatment.
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The GLIA-Baek Hyun-Sook/Frank Kirchhoff team found that a group of OPCs did not express Olig2, and that acute brain injury and learning activities promoted the formation of this group of cells
Time of Update: 2023-01-06
On October 29, 2022, Hyun-sook Baek and Frank Kirchhoff (Academician of the European Academy of Sciences) from the Department of Molecular Physiology at Saarland University in Germany were in the team A subset of OPCs do not express Olig2 during development which can be increased in the adult by brain injuries and complex motor was published in the GLIA publication learning".