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Neuron Mo Wei/Zhang Liang/Hu Jin of Xiamen University revealed that microglia sense amyloid plaque hardness through Piezo1 to limit the progression of Alzheimer's disease
Time of Update: 2023-01-06
Original link: 00954-0—END—The content is [iNature]iNatureThe pathological feature of Alzheimer's disease (AD) is extracellular amyloid-β (Aβ) plaques, the effect of which on the mechanical properties of surrounding brain tissue is unknown.
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Winning Zai Future Elite Club, MG Youth Original Scientific Research Forum 2022 Summit Wonderful Review
Time of Update: 2023-01-06
In the past 10 years, research results in the field of myasthenia gravis (MG) in China have emerged, and the number of papers published has ranked among the top in the world. In order to further encou
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Can cerebral infarction in elderly patients be thrombolysis? See what the top issue has to say!
Time of Update: 2023-01-06
A 2014 review published in Lancet in nine clinical trials (6756 patients with ischemic stroke treated with alteplase) (Figure 2) showed that people over 80 years of age still benefit from intravenous thrombolysis with alteplase within 3.
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Hu Gang's team revealed that microglia promote toxic astrocytes formation and induce depression-like behavior
Time of Update: 2023-01-06
1038/s41586-022-05328-2The images in the article are from referencesFigure 1: Increased activation of hippocampal neurotoxic astrocytes after stress2NLRP3 regulates the increase of astrocytes in the hippocampusGiven that NLRP3 regulates phenotypic transitions in A1 astrocytes and increases hippocampal NLRP3 levels after CMS, they constructed NLRP3 total knockout mice and found that knocking out NLRP3 was able to attenuate CMS-induced depression-like behavioral disorders, reduce the number of hippocampal A1 astrocytes, and attenuate synaptic protein loss.
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New RCTs for the treatment of acute ischaemic stroke with ginkgolide injection released
Time of Update: 2023-01-06
On October 28, 2022, the "RCT New Evidence for Antiplatelet Treatment of Ginkgolide Acute Ischemic Stroke" live broadcast satellite meeting, hosted by the Shanghai Stroke Society and co-organized by C
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New RCTs for the treatment of acute ischaemic stroke with ginkgolide injection released
Time of Update: 2023-01-06
On October 28, 2022, the "RCT New Evidence for Antiplatelet Treatment of Ginkgolide Acute Ischemic Stroke" live broadcast satellite meeting, hosted by the Shanghai Stroke Society and co-organized by C
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The risk of stroke in young people has risen dramatically! JAMA is here to give you a wake-up call
Time of Update: 2023-01-06
conclusionUsing data from the Oxford Vascular Study, the researchers explored whether stroke rates changed between 2002 and older people in young and old people, which included 94,567 people registered at GP clinics in Oxfordshire.
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JAMA Sub-issue: Discover blood markers to evaluate the efficacy of Alzheimer's disease drugs!
Time of Update: 2023-01-06
At baseline, plasma pTau217 levels in AD patients were significantly positively correlated with brain amyloid plaques and Tau protein deposition on Aβ and Tau PET imagingNext, the researchers analyzed changes in plasma biomarkers in AD patients after Donanemab treatment.
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Academician Cell Review! Xu Huaqiang/Xie Xin/Wang Mingwei/Zhuang Youwen revealed the mechanism of action of morphine and fentanyl, and powerful analgesics got rid of addiction one step further
Time of Update: 2023-01-06
iNatureOn November 10, 2022, the team of Xu Huaqiang, Xie Xin, and Wang Mingwei, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, cooperated in publishing a long article entitled "Mo
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Migraine attacks suffering? Finding the right medicine is key!
Time of Update: 2023-01-06
▼▼▼Click to read the original article to download the AppDownloadDecision Assistant App, the guide is free at any time~References:References:[1] Guidelines for the prevention and treatment of migraine in China (2016).
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Is there also benefit in patients with seronegative myasthenia gravis? One of the 2022 AANEM Essentials Hot Review Series
Time of Update: 2023-01-06
GuideMG (myasthenia gravis) is an antibody-mediated autoimmune disease, acetylcholine receptor (AChR) antibodies are the most common pathogenic antibodies, AChR antibodies are present in about 85% of
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Expert Review: Cell Xu Huaqiang/Xie Xin/Wang Mingwei/Zhuang Youwen collaborated to reveal the mechanism of action of the powerful analgesics fentanyl and morphine
Time of Update: 2023-01-06
On November 10, 2022, the team of Xu Huaqiang/Zhuang Youwen, Xie Xin's team and Wang Mingwei's team from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences published a long article entitled Molecular recognition of morphine and fentanyl by the human μ-opioid online Research paper by Receptor.
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Nature: Mediating the "new culprit" of AD deposition, amyloid medin in cerebral blood vessels promotes Aβ aggregation
Time of Update: 2023-01-06
1038/s41586-022-05440-3The images in the article are from referencesFigure 1: medin promotes the deposition of cerebral vascular Aβ2medin mediates cognitive impairment in AD patients by inducing CAATo study the role of medin in the pathological process in AD patients, the researchers collected cortical samples from 16 AD deceased patients and found that medin had obvious colocalization with Aβ.
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For the first time, the Xiangya Hospital team confirmed that there is no causal relationship between Alzheimer's disease and age-related macular degeneration
Time of Update: 2023-01-06
The IVW method was used to study the bidirectional causality table between genetic susceptibility to late AMD and ADThe results showed that the genetic susceptibility to late AMD was not related to AD risk, and there was a consistent zero association across different AD datasets (see table above, P values were all greater than 0.
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GnRH replacement therapy has had amazing benefits for people with Down syndrome
Time of Update: 2023-01-06
European researchers have observed that DS patients also have fewer neurons producing gonadotropin-releasing hormone (GnRH) over time, so they wanted to understand whether this was the cause of cognitive loss.
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The GLIA-Baek Hyun-Sook/Frank Kirchhoff team found that a group of OPCs did not express Olig2, and that acute brain injury and learning activities promoted the formation of this group of cells
Time of Update: 2023-01-06
On October 29, 2022, Hyun-sook Baek and Frank Kirchhoff (Academician of the European Academy of Sciences) from the Department of Molecular Physiology at Saarland University in Germany were in the team A subset of OPCs do not express Olig2 during development which can be increased in the adult by brain injuries and complex motor was published in the GLIA publication learning".
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Chiropractic Rejuvenation and Concerted Efforts Review of the 1st Adult Spinal Muscular Atrophy Summit Forum
Time of Update: 2023-01-06
Professor Zhang Min: Real-world studies enrich the evidence for the treatment of SMA in adults, and DMT drugs bring significant benefitsProfessor Zhang Min, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology➤ Several pivotal studies confirm the efficacy and safety of nocinaxen in children and adultsMultiple natural history studies have found progressive decline in functions in patients with SMA.
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Ischemic stroke CISS classification and TOAST classification, clarified in one article
Time of Update: 2023-01-06
TOAST typing: cardioembolic high-risk, intermediate-risk embolic sources(Author's homemade)03 Small-artery occlusion lacunar (SAA):(1) Manifested as classic clinical lacunar syndrome with no evidence of cortical dysfunction;(2) a history of previous diabetes or hypertension is helpful in the diagnosis of this type;(3) Brain CT/MRI examination is normal, or there are lesions with a diameter of < 1.
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How is frontotemporal degeneration diagnosed? Take a look at the latest Chinese expert consensus
Time of Update: 2023-01-06
Genetics and neuropathologyRecommendation 14: In view of the genetic characteristics of FTLD, it is recommended that patients with a clear family history of dementia, early-onset sporadic cases, special clinical phenotypes, and superimposed syndromes undergo genetic testing as soon as possible to assist diagnosis and subtype classification, which is conducive to early intervention (level I recommendation, level A evidence).
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Can you lose weight by smelling it? The latest research has found that food odor regulates fat metabolism
Time of Update: 2023-01-06
Food odor exposure causes lipid mobilization during fasting To elucidate metabolic changes in mice in the presence or absence of food odor stimuli, the researchers measured unesterified fatty acids (NEFA) serum levels, which are the main source of energy during fasting.
