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Courier Alzheimer's Disease Drug Phase 2 Interim Clinical Results Positive! Significant improvement in agitation symptoms
Time of Update: 2023-01-06
▲If you have any business needs, please press and hold to scan the QR code above, or▎WuXi AppTec content team editorSciSparc today announced the positive interim results of a Phase 2a trial of its drug SCI-110 in the treatment of Alzheimer's disease (AD) patients with agitated symptoms.
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Courier Alzheimer's Disease Drug Phase 2 Interim Clinical Results Positive! Significant improvement in agitation symptoms
Time of Update: 2023-01-06
▲If you have any business needs, please press and hold to scan the QR code above, or▎WuXi AppTec content team editorSciSparc today announced the positive interim results of a Phase 2a trial of its drug SCI-110 in the treatment of Alzheimer's disease (AD) patients with agitated symptoms.
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Neuron Liu Kai's team found that activating type II interferon and cGAS-STING signaling pathways in the nervous system can promote axon regeneration
Time of Update: 2023-01-06
On November 11, 2022, Liu Kai's research group of the Hong Kong University of Science and Technology published a long article "Driving Axon Regeneration by Orchestrating Neuronal and Non-neuronal Innate Immune Responses via the" in Neuron IFNγ-cGAS-STING Axis, found that by knocking out PTPN2 and adding type II interferon stimulated genes (ISGs) in neurons including the cGAS-STING pathway, it was possible to activate interferon stimulated genes (ISGs).
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Cell: Why do we feel?
Time of Update: 2023-01-06
The work of cat-based organisms pointed out that postsynaptic dorsal column neurons (PSDCs) located in the central region of the dorsal horn show obvious mechanoceptive properties and have a projection area of maximum and high complexity 。 Of particular note is the presence of inhibitory and excitatory interneurons with different morphological and physiological traits in the dorsal horn, which can support mechanosensory signal output.
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GnRH replacement therapy has had amazing benefits for people with Down syndrome
Time of Update: 2023-01-06
European researchers have observed that DS patients also have fewer neurons producing gonadotropin-releasing hormone (GnRH) over time, so they wanted to understand whether this was the cause of cognitive loss.
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Nature: Mediating the "new culprit" of AD deposition, amyloid medin in cerebral blood vessels promotes Aβ aggregation
Time of Update: 2023-01-06
1038/s41586-022-05440-3The images in the article are from referencesFigure 1: medin promotes the deposition of cerebral vascular Aβ2medin mediates cognitive impairment in AD patients by inducing CAATo study the role of medin in the pathological process in AD patients, the researchers collected cortical samples from 16 AD deceased patients and found that medin had obvious colocalization with Aβ.
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Research reveals the basis of neural circuits in the occurrence of psychiatric symptoms in Alzheimer's disease
Time of Update: 2023-01-06
On November 1, Li Jiali, a researcher at the Kunming Institute of Zoology, Chinese Academy of Sciences, published a research paper entitled Hyper-excitability of corticothalamic PT neurons in mPFC promotes irritability in the mouse model of Alzheimer's disease in Cell Reports 。 This paper uses a mouse disease model to analyze the neural circuit mechanism of irritability symptoms in Alzheimer's disease.
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Research reveals the basis of neural circuits in the occurrence of psychiatric symptoms in Alzheimer's disease
Time of Update: 2023-01-06
On November 1, Li Jiali, a researcher at the Kunming Institute of Zoology, Chinese Academy of Sciences, published a research paper entitled Hyper-excitability of corticothalamic PT neurons in mPFC promotes irritability in the mouse model of Alzheimer's disease in Cell Reports 。 This paper uses a mouse disease model to analyze the neural circuit mechanism of irritability symptoms in Alzheimer's disease.
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Academician Cell Review! Xu Huaqiang/Xie Xin/Wang Mingwei/Zhuang Youwen revealed the mechanism of action of morphine and fentanyl, and powerful analgesics got rid of addiction one step further
Time of Update: 2023-01-06
iNatureOn November 10, 2022, the team of Xu Huaqiang, Xie Xin, and Wang Mingwei, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, cooperated in publishing a long article entitled "Mo
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Nature allows paralyzed patients to regain the ability to walk
Time of Update: 2023-01-06
Written by | JunSpinal cord injury (SCI) interrupts the connection from the brain and brainstem to the lumbar spinal cord, leaving the patient unable to walk and permanently paralyzed. Previous studie
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The Transl Psychiatry-Suiqiang Zhu/Zhou Zhu team revealed that structural disconnection due to stroke predicts the risk of depression after stroke
Time of Update: 2023-01-06
Written by Pan Chensheng, Zhu ZhouResponsible editor—Wang Sizhen, Fang YiyiEditor—Summer LeafPost-stroke depression (PSD) occurs in about one-third of stroke people, and is associated with poor post-s
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Nature Communications: Inhibit neural circuits for undesirable motivational behavior, or reduce drug addiction
Time of Update: 2023-01-06
1038/s41467-022-34517-wThe images in the article are from referencesPVT excitatorycan also blockFigure 2: NAc region small albumin neurons mediate inhibitory reward behavior3Opioids dissociate their receptors and inhibit rewarding effectsIntraperitoneal injection of the opioid heroin significantly reduced the neuronal activity of PVT →NAc circuit.
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Although "late", Chinese and American experts gathered in Chengdu to discuss the experience of diagnosis and treatment of adult tardive dyskinesia
Time of Update: 2023-01-06
On October 29, 2022, the first Deuterium Tetraphenazine China and West International Summit Forum was successfully held in Chengdu, where many experts in psychiatry and neurology at home and abroad shared their experience in TD and HD treatment, opening up a smooth life for more patients.
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Patients can use efgartigimod early and seek greater benefits! 2022 AANEM Essence Hot Review No. 3
Time of Update: 2023-01-06
Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies, with impaired transmission of acquired neuro-muscle junctions (NMJs). 。 Acetylcholine receptor (AChR) antibodies are the mos
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Neuron Mo Wei/Zhang Liang/Hu Jin of Xiamen University revealed that microglia sense amyloid plaque hardness through Piezo1 to limit the progression of Alzheimer's disease
Time of Update: 2023-01-06
Original link: 00954-0—END—The content is [iNature]iNatureThe pathological feature of Alzheimer's disease (AD) is extracellular amyloid-β (Aβ) plaques, the effect of which on the mechanical properties of surrounding brain tissue is unknown.
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For the first time, the Xiangya Hospital team confirmed that there is no causal relationship between Alzheimer's disease and age-related macular degeneration
Time of Update: 2023-01-06
The IVW method was used to study the bidirectional causality table between genetic susceptibility to late AMD and ADThe results showed that the genetic susceptibility to late AMD was not related to AD risk, and there was a consistent zero association across different AD datasets (see table above, P values were all greater than 0.
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NEJM sub-journal: Improve the cognition of people with mild cognitive impairment, crossword puzzles are very good!
Time of Update: 2023-01-06
In addition, in subjects with late MCI, the change in ADAS-Cog score was manifested as cognitive decline in the computer game group and improvement in cognitive function in the crossword group at week 12 (LS mean difference: -1.
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The risk of stroke in young people has risen dramatically! JAMA is here to give you a wake-up call
Time of Update: 2023-01-06
conclusionUsing data from the Oxford Vascular Study, the researchers explored whether stroke rates changed between 2002 and older people in young and old people, which included 94,567 people registered at GP clinics in Oxfordshire.
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New RCTs for the treatment of acute ischaemic stroke with ginkgolide injection released
Time of Update: 2023-01-06
On October 28, 2022, the "RCT New Evidence for Antiplatelet Treatment of Ginkgolide Acute Ischemic Stroke" live broadcast satellite meeting, hosted by the Shanghai Stroke Society and co-organized by C
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New RCTs for the treatment of acute ischaemic stroke with ginkgolide injection released
Time of Update: 2023-01-06
On October 28, 2022, the "RCT New Evidence for Antiplatelet Treatment of Ginkgolide Acute Ischemic Stroke" live broadcast satellite meeting, hosted by the Shanghai Stroke Society and co-organized by C