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NEJM sub-journal: Improve the cognition of people with mild cognitive impairment, crossword puzzles are very good!
Time of Update: 2023-01-06
In addition, in subjects with late MCI, the change in ADAS-Cog score was manifested as cognitive decline in the computer game group and improvement in cognitive function in the crossword group at week 12 (LS mean difference: -1.
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Courier Alzheimer's Disease Drug Phase 2 Interim Clinical Results Positive! Significant improvement in agitation symptoms
Time of Update: 2023-01-06
▲If you have any business needs, please press and hold to scan the QR code above, or▎WuXi AppTec content team editorSciSparc today announced the positive interim results of a Phase 2a trial of its drug SCI-110 in the treatment of Alzheimer's disease (AD) patients with agitated symptoms.
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Courier Alzheimer's Disease Drug Phase 2 Interim Clinical Results Positive! Significant improvement in agitation symptoms
Time of Update: 2023-01-06
▲If you have any business needs, please press and hold to scan the QR code above, or▎WuXi AppTec content team editorSciSparc today announced the positive interim results of a Phase 2a trial of its drug SCI-110 in the treatment of Alzheimer's disease (AD) patients with agitated symptoms.
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Patients can use efgartigimod early and seek greater benefits! 2022 AANEM Essence Hot Review No. 3
Time of Update: 2023-01-06
Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies, with impaired transmission of acquired neuro-muscle junctions (NMJs). 。 Acetylcholine receptor (AChR) antibodies are the mos
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How is frontotemporal degeneration diagnosed? Take a look at the latest Chinese expert consensus
Time of Update: 2023-01-06
Genetics and neuropathologyRecommendation 14: In view of the genetic characteristics of FTLD, it is recommended that patients with a clear family history of dementia, early-onset sporadic cases, special clinical phenotypes, and superimposed syndromes undergo genetic testing as soon as possible to assist diagnosis and subtype classification, which is conducive to early intervention (level I recommendation, level A evidence).
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Can you lose weight by smelling it? The latest research has found that food odor regulates fat metabolism
Time of Update: 2023-01-06
Food odor exposure causes lipid mobilization during fasting To elucidate metabolic changes in mice in the presence or absence of food odor stimuli, the researchers measured unesterified fatty acids (NEFA) serum levels, which are the main source of energy during fasting.
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Nervous about the exam and can't remember the knowledge points? Zhong Yi's team at Tsinghua University revealed the neurobiological mechanism of emotional state-mediated memory retrieval
Time of Update: 2023-01-06
Adult newborn granule cells confer emotionalstate–dependent adaptability in memory retrievalThe images in the article are from referencesClick on the blue word to follow usAnimals can flexibly extract relevant memories according to the current state, different emotional experiences have obvious regulatory effects on the memory process, acute stress can hinder memory retrieval, and rich environment will enhance memory acquisition, but there is still little understanding of how the hippocampal brain region integrates different emotional experiences into the memory process.
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Nervous about the exam and can't remember the knowledge points? Zhong Yi's team at Tsinghua University revealed the neurobiological mechanism of emotional state-mediated memory retrieval
Time of Update: 2023-01-06
Adult newborn granule cells confer emotionalstate–dependent adaptability in memory retrievalThe images in the article are from referencesClick on the blue word to follow usAnimals can flexibly extract relevant memories according to the current state, different emotional experiences have obvious regulatory effects on the memory process, acute stress can hinder memory retrieval, and rich environment will enhance memory acquisition, but there is still little understanding of how the hippocampal brain region integrates different emotional experiences into the memory process.
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Focus on breathing and swallowing to see the new progress in the correction and treatment of spinal muscular atrophy
Time of Update: 2023-01-06
The Expert Consensus on Respiratory Management of Spinal Muscular Atrophy (2022 Edition) emphasizes that reasonable and effective respiratory management strategies are of great significance to stabilize the respiratory function of patients with SMA and reduce the incidence of respiratory related complications and disease mortality.
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Cell: Why do we feel?
Time of Update: 2023-01-06
The work of cat-based organisms pointed out that postsynaptic dorsal column neurons (PSDCs) located in the central region of the dorsal horn show obvious mechanoceptive properties and have a projection area of maximum and high complexity 。 Of particular note is the presence of inhibitory and excitatory interneurons with different morphological and physiological traits in the dorsal horn, which can support mechanosensory signal output.
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Fighting insomnia is just one step! Studies have shown that the thicker the quilt, the more melatonin is secreted...
Time of Update: 2023-01-06
Research process 02 02For the study, researchers selected 26 young, healthy participants, including 15 men and 11 women, to investigate whether the use of a thick quilt (about 12% of body weight) before bed resulted in higher concentrations of melatonin and oxytocin in saliva than light quilt (about 2.
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"Nature" blockbuster: MIT cow Cai Lihui's team found for the first time that ApoE4 causes cholesterol to be deposited inside oligodendrocytes, intervening in cholesterol or becoming a new treatment for Alzheimer's disease
Time of Update: 2023-01-06
*For medical professionals onlyExcited heart, trembling hands, my idol Teacher Cai, sent "Nature" again!A few days ago, two phase 3 clinical trials of gantenerumab announced that they did not reach th
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The GLIA-Baek Hyun-Sook/Frank Kirchhoff team found that a group of OPCs did not express Olig2, and that acute brain injury and learning activities promoted the formation of this group of cells
Time of Update: 2023-01-06
On October 29, 2022, Hyun-sook Baek and Frank Kirchhoff (Academician of the European Academy of Sciences) from the Department of Molecular Physiology at Saarland University in Germany were in the team A subset of OPCs do not express Olig2 during development which can be increased in the adult by brain injuries and complex motor was published in the GLIA publication learning".
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Chiropractic Rejuvenation and Concerted Efforts Review of the 1st Adult Spinal Muscular Atrophy Summit Forum
Time of Update: 2023-01-06
Professor Zhang Min: Real-world studies enrich the evidence for the treatment of SMA in adults, and DMT drugs bring significant benefitsProfessor Zhang Min, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology➤ Several pivotal studies confirm the efficacy and safety of nocinaxen in children and adultsMultiple natural history studies have found progressive decline in functions in patients with SMA.
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Ischemic stroke CISS classification and TOAST classification, clarified in one article
Time of Update: 2023-01-06
TOAST typing: cardioembolic high-risk, intermediate-risk embolic sources(Author's homemade)03 Small-artery occlusion lacunar (SAA):(1) Manifested as classic clinical lacunar syndrome with no evidence of cortical dysfunction;(2) a history of previous diabetes or hypertension is helpful in the diagnosis of this type;(3) Brain CT/MRI examination is normal, or there are lesions with a diameter of < 1.
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Cell Mice with Williams syndrome have superior audio discrimination ability
Time of Update: 2023-01-06
In summary, the authors have superior audio discrimination ability through a mouse model of Williams syndrome, and this ability is caused by the downregulation of inhibitory interneuron Vipr1 in the auditory cortex.
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Sleep strengthens memory, but not the bad ones! Scientific studies have found that shorter naps do not increase fear-related memories
Time of Update: 2023-01-06
Pavlov and his research team from the Institute of Medical Psychology and Behavioral Neurobiology at the University of Tübingen made healthy subjects receive conditioned fear memory, compared the subjects' response to re-exposure to fear conditions after a 2-hour nap or corresponding waking time, and found that sleep did not enhance the subjects' fear-response behavior, nor did it affect brain event-related potentials (ERP); Fear memories are gradually consolidated over time and are independent of whether or not to nap.
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Express alleviates the symptoms of Parkinson's disease, and the new treatment is expected to be approved in the first half of next year
Time of Update: 2023-01-06
▲If you have any business needs, please press and hold to scan the QR code above, or▎WuXi AppTec content team editorToday, Amneal Pharmaceuticals announced that the U.
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Nature Zhong's team discovered a "brake" mechanism for the brain's control of motion
Time of Update: 2023-01-06
On November 9, 2022, the team of Haining Zhong at the Vollum Institute of Health and Science University of Oregon published an article in Nature magazine, Locomotion activates PKA through dopamine and adenosine in striatal neurons , revealing a new "brake" mechanism in motor control in the striatum of the brain, opening new avenues for the treatment of Parkinson's and other diseases associated with the striatum.
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Cell: Why are mosquitoes chasing and biting you? Scientists have revealed that the higher the expression of carboxylic acids in the skin, the more attractive mosquitoes are
Time of Update: 2023-01-06
1038/s41586-022-05328-2The images in the article are from referencesFigure 1: Different human individuals of mosquitoes show obvious preference2Mosquito highly attractive people have increased levels of carboxylic acids in the skin odorMosquitoes perceive olfactory information through two types of odor-gated ion channels, odor receptors (OR) and ionic receptors (IR).
