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Chiropractic Rejuvenation and Concerted Efforts Review of the 1st Adult Spinal Muscular Atrophy Summit Forum
Time of Update: 2023-01-06
Professor Zhang Min: Real-world studies enrich the evidence for the treatment of SMA in adults, and DMT drugs bring significant benefitsProfessor Zhang Min, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology➤ Several pivotal studies confirm the efficacy and safety of nocinaxen in children and adultsMultiple natural history studies have found progressive decline in functions in patients with SMA.
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Cell Mice with Williams syndrome have superior audio discrimination ability
Time of Update: 2023-01-06
In summary, the authors have superior audio discrimination ability through a mouse model of Williams syndrome, and this ability is caused by the downregulation of inhibitory interneuron Vipr1 in the auditory cortex.
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Nature Communications: Inhibit neural circuits for undesirable motivational behavior, or reduce drug addiction
Time of Update: 2023-01-06
1038/s41467-022-34517-wThe images in the article are from referencesPVT excitatorycan also blockFigure 2: NAc region small albumin neurons mediate inhibitory reward behavior3Opioids dissociate their receptors and inhibit rewarding effectsIntraperitoneal injection of the opioid heroin significantly reduced the neuronal activity of PVT →NAc circuit.
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Research reveals the basis of neural circuits in the occurrence of psychiatric symptoms in Alzheimer's disease
Time of Update: 2023-01-06
On November 1, Li Jiali, a researcher at the Kunming Institute of Zoology, Chinese Academy of Sciences, published a research paper entitled Hyper-excitability of corticothalamic PT neurons in mPFC promotes irritability in the mouse model of Alzheimer's disease in Cell Reports 。 This paper uses a mouse disease model to analyze the neural circuit mechanism of irritability symptoms in Alzheimer's disease.
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Research reveals the basis of neural circuits in the occurrence of psychiatric symptoms in Alzheimer's disease
Time of Update: 2023-01-06
On November 1, Li Jiali, a researcher at the Kunming Institute of Zoology, Chinese Academy of Sciences, published a research paper entitled Hyper-excitability of corticothalamic PT neurons in mPFC promotes irritability in the mouse model of Alzheimer's disease in Cell Reports 。 This paper uses a mouse disease model to analyze the neural circuit mechanism of irritability symptoms in Alzheimer's disease.
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The Transl Psychiatry-Suiqiang Zhu/Zhou Zhu team revealed that structural disconnection due to stroke predicts the risk of depression after stroke
Time of Update: 2023-01-06
Written by Pan Chensheng, Zhu ZhouResponsible editor—Wang Sizhen, Fang YiyiEditor—Summer LeafPost-stroke depression (PSD) occurs in about one-third of stroke people, and is associated with poor post-s
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Academician Cell Review! Xu Huaqiang/Xie Xin/Wang Mingwei/Zhuang Youwen revealed the mechanism of action of morphine and fentanyl, and powerful analgesics got rid of addiction one step further
Time of Update: 2023-01-06
iNatureOn November 10, 2022, the team of Xu Huaqiang, Xie Xin, and Wang Mingwei, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, cooperated in publishing a long article entitled "Mo
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Nature allows paralyzed patients to regain the ability to walk
Time of Update: 2023-01-06
Written by | JunSpinal cord injury (SCI) interrupts the connection from the brain and brainstem to the lumbar spinal cord, leaving the patient unable to walk and permanently paralyzed. Previous studie
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Although "late", Chinese and American experts gathered in Chengdu to discuss the experience of diagnosis and treatment of adult tardive dyskinesia
Time of Update: 2023-01-06
On October 29, 2022, the first Deuterium Tetraphenazine China and West International Summit Forum was successfully held in Chengdu, where many experts in psychiatry and neurology at home and abroad shared their experience in TD and HD treatment, opening up a smooth life for more patients.
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New RCTs for the treatment of acute ischaemic stroke with ginkgolide injection released
Time of Update: 2023-01-06
On October 28, 2022, the "RCT New Evidence for Antiplatelet Treatment of Ginkgolide Acute Ischemic Stroke" live broadcast satellite meeting, hosted by the Shanghai Stroke Society and co-organized by C
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New RCTs for the treatment of acute ischaemic stroke with ginkgolide injection released
Time of Update: 2023-01-06
On October 28, 2022, the "RCT New Evidence for Antiplatelet Treatment of Ginkgolide Acute Ischemic Stroke" live broadcast satellite meeting, hosted by the Shanghai Stroke Society and co-organized by C
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Migraine attacks suffering? Finding the right medicine is key!
Time of Update: 2023-01-06
▼▼▼Click to read the original article to download the AppDownloadDecision Assistant App, the guide is free at any time~References:References:[1] Guidelines for the prevention and treatment of migraine in China (2016).
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Patients can use efgartigimod early and seek greater benefits! 2022 AANEM Essence Hot Review No. 3
Time of Update: 2023-01-06
Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies, with impaired transmission of acquired neuro-muscle junctions (NMJs). 。 Acetylcholine receptor (AChR) antibodies are the mos
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Neuron Mo Wei/Zhang Liang/Hu Jin of Xiamen University revealed that microglia sense amyloid plaque hardness through Piezo1 to limit the progression of Alzheimer's disease
Time of Update: 2023-01-06
Original link: 00954-0—END—The content is [iNature]iNatureThe pathological feature of Alzheimer's disease (AD) is extracellular amyloid-β (Aβ) plaques, the effect of which on the mechanical properties of surrounding brain tissue is unknown.
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For the first time, the Xiangya Hospital team confirmed that there is no causal relationship between Alzheimer's disease and age-related macular degeneration
Time of Update: 2023-01-06
The IVW method was used to study the bidirectional causality table between genetic susceptibility to late AMD and ADThe results showed that the genetic susceptibility to late AMD was not related to AD risk, and there was a consistent zero association across different AD datasets (see table above, P values were all greater than 0.
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Cell: Why are mosquitoes chasing and biting you? Scientists have revealed that the higher the expression of carboxylic acids in the skin, the more attractive mosquitoes are
Time of Update: 2023-01-06
1038/s41586-022-05328-2The images in the article are from referencesFigure 1: Different human individuals of mosquitoes show obvious preference2Mosquito highly attractive people have increased levels of carboxylic acids in the skin odorMosquitoes perceive olfactory information through two types of odor-gated ion channels, odor receptors (OR) and ionic receptors (IR).
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Sleep strengthens memory, but not the bad ones! Scientific studies have found that shorter naps do not increase fear-related memories
Time of Update: 2023-01-06
Pavlov and his research team from the Institute of Medical Psychology and Behavioral Neurobiology at the University of Tübingen made healthy subjects receive conditioned fear memory, compared the subjects' response to re-exposure to fear conditions after a 2-hour nap or corresponding waking time, and found that sleep did not enhance the subjects' fear-response behavior, nor did it affect brain event-related potentials (ERP); Fear memories are gradually consolidated over time and are independent of whether or not to nap.
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Ischemic stroke CISS classification and TOAST classification, clarified in one article
Time of Update: 2023-01-06
TOAST typing: cardioembolic high-risk, intermediate-risk embolic sources(Author's homemade)03 Small-artery occlusion lacunar (SAA):(1) Manifested as classic clinical lacunar syndrome with no evidence of cortical dysfunction;(2) a history of previous diabetes or hypertension is helpful in the diagnosis of this type;(3) Brain CT/MRI examination is normal, or there are lesions with a diameter of < 1.
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Illustrative Through writing and drawing, you can easily identify various tremors
Time of Update: 2023-01-06
Through the drawing of the straight line, it can be seen that the left hand (main) vertical line has 18 tremors in 2 seconds, with an estimated frequency of 9Hz. C: In this example, a plot drawn by a patient with severe essential tremor shows a clear large tremor in the unidirectional axis, with fairly regular amplitude and frequency, and bilateral symmetry.
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Nature: Allowed 9 paralyzed patients to regain the ability to walk, and now the cause is finally understood
Time of Update: 2023-01-06
Link to Grégoire Courtine (right) and Jocelyne Bloch (left): style="caret-color: rgb(255, 0, 0);font-family: , "Microsoft YaHei", sans-serif;color: rgb(136, 136, 136);font-size: 12px;letter-spacing: normal;" _mstmutation="1" _istranslated="1"> open reprint, welcome to forward to Moments and WeChat groups Written byTwo pearsSourceLilac AcademicAs early as 30 years ago, preclinical and clinical studies showed that epidural electrical stimulation (ESS) on the lumbosacral spinal cord restored the ability to walk in patients with spinal cord injury.