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The INT J CANCER-XIA/PENG LIANG TEAM REVEALED THAT GLIOMA CELL-NEURON SYNAPTIC CONNECTIONS ARE IMPORTANT FACTORS AFFECTING THE SPATIAL PATHOGENESIS OF CELL TUMORS
Time of Update: 2023-01-06
The authors first constructed GBM and LGG by using the patient image data of the Department of Neurosurgery of Harbin Medical University Cancer Hospital and the public resources of the imaging database The Cancer Imaging Archive and spatial probability distribution plots of gliomas of different molecular subtypes (Figure 1).
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Focus on breathing and swallowing to see the new progress in the correction and treatment of spinal muscular atrophy
Time of Update: 2023-01-06
The Expert Consensus on Respiratory Management of Spinal Muscular Atrophy (2022 Edition) emphasizes that reasonable and effective respiratory management strategies are of great significance to stabilize the respiratory function of patients with SMA and reduce the incidence of respiratory related complications and disease mortality.
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Sleep strengthens memory, but not the bad ones! Scientific studies have found that shorter naps do not increase fear-related memories
Time of Update: 2023-01-06
Pavlov and his research team from the Institute of Medical Psychology and Behavioral Neurobiology at the University of Tübingen made healthy subjects receive conditioned fear memory, compared the subjects' response to re-exposure to fear conditions after a 2-hour nap or corresponding waking time, and found that sleep did not enhance the subjects' fear-response behavior, nor did it affect brain event-related potentials (ERP); Fear memories are gradually consolidated over time and are independent of whether or not to nap.
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Nature's blockbuster breakthrough! For the first time, the neural mechanism of striatal dopamine adenosine affecting PKA activity was revealed, which helped Parkinson's drug research new strategies
Time of Update: 2023-01-06
1038/s41586-022-05407-4 In vivo PKA imaging revealed the cell-specific regulation of PKA by DA The author injected adeno-associated virus (AAV) (a PKA probe) into DLS in D1R-Cre or Adora2a-cre mice, implanted GRIN lens, and added two-photon fluorescence lifetime microscopy (2pFLIM) technology to achieve in vivo imaging of dSPN or iSPN PKA for the first time , PKA activity in SPN under basal conditions was successfully discovered.
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How to distinguish "peripheral vertigo" from "central vertigo"?
Time of Update: 2023-01-06
Come to the "doctor's station" and take a look 👇Acute vestibular syndrome = acute onset of vertigo + severe and persistent symptoms + vertigo worsening due to change in head position + visible nystagmus visible by gaze.
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How to distinguish "peripheral vertigo" from "central vertigo"?
Time of Update: 2023-01-06
Come to the "doctor's station" and take a look 👇Acute vestibular syndrome = acute onset of vertigo + severe and persistent symptoms + vertigo worsening due to change in head position + visible nystagmus visible by gaze.
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Can you lose weight by smelling it? The latest research has found that food odor regulates fat metabolism
Time of Update: 2023-01-06
Food odor exposure causes lipid mobilization during fasting To elucidate metabolic changes in mice in the presence or absence of food odor stimuli, the researchers measured unesterified fatty acids (NEFA) serum levels, which are the main source of energy during fasting.
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How is frontotemporal degeneration diagnosed? Take a look at the latest Chinese expert consensus
Time of Update: 2023-01-06
Genetics and neuropathologyRecommendation 14: In view of the genetic characteristics of FTLD, it is recommended that patients with a clear family history of dementia, early-onset sporadic cases, special clinical phenotypes, and superimposed syndromes undergo genetic testing as soon as possible to assist diagnosis and subtype classification, which is conducive to early intervention (level I recommendation, level A evidence).
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Summaptan, Zolmitriptan... One article masters the treatment of "cluster headache"
Time of Update: 2023-01-06
*For medical professionals onlyThese 5 things to know!Cluster headache (CH) is often clinically manifested as severe pain in the orbital, supraorbital, and/or temporal region of the strict unilateral
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CNS Neuroscience & Therapeutics: Butylphthalide combined with recanalization is safe and effective
Time of Update: 2023-01-06
Research methodsThis study was analyzed using data from three EVT studies on LVO leading to AIS patients, including: the BASILAR study (coverage 47 A national registry study of acute basilar artery occlusion in stroke centres), the DEVT study (a multicentre open-label randomized controlled trial covering anterior circulation LVOs in 33 stroke centres), and one study on national LVOs A multicenter study of the safety and efficacy of endovascular therapy for AIS.
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CNS Neuroscience & Therapeutics: Butylphthalide combined with recanalization is safe and effective
Time of Update: 2023-01-06
Research methodsThis study was analyzed using data from three EVT studies on LVO leading to AIS patients, including: the BASILAR study (coverage 47 A national registry study of acute basilar artery occlusion in stroke centres), the DEVT study (a multicentre open-label randomized controlled trial covering anterior circulation LVOs in 33 stroke centres), and one study on national LVOs A multicenter study of the safety and efficacy of endovascular therapy for AIS.
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NKGen advances NK cell therapy for Parkinson's, "tumor killer" can also treat neurodegenerative diseases?
Time of Update: 2023-01-06
The focus is on helping to accelerate NKGen's clinical program through its network of clinical partners and donors using its novel autologous NK cell therapy SNK01 for the treatment of advanced Parkinson's disease ( Parkinson’s disease,PD)。 Parkinson's disease is the second most common chronic, progressively developing central neurodegenerative disease after Alzheimer's disease, affecting nearly 10 million people worldwide.
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Electric sparks in the brain: stories of ion channels and nerve cells
Time of Update: 2023-01-06
Electric sparks in the brain: stories of ion channels and nerve cellsauthorTranslated by Bert Sakmann (Professor at the Max Planck Institute for Neurobiology, winner of the 1991 Nobel Prize in Physiology and Medicine).
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Ischemic stroke CISS classification and TOAST classification, clarified in one article
Time of Update: 2023-01-06
TOAST typing: cardioembolic high-risk, intermediate-risk embolic sources(Author's homemade)03 Small-artery occlusion lacunar (SAA):(1) Manifested as classic clinical lacunar syndrome with no evidence of cortical dysfunction;(2) a history of previous diabetes or hypertension is helpful in the diagnosis of this type;(3) Brain CT/MRI examination is normal, or there are lesions with a diameter of < 1.
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Illustrative Through writing and drawing, you can easily identify various tremors
Time of Update: 2023-01-06
Through the drawing of the straight line, it can be seen that the left hand (main) vertical line has 18 tremors in 2 seconds, with an estimated frequency of 9Hz. C: In this example, a plot drawn by a patient with severe essential tremor shows a clear large tremor in the unidirectional axis, with fairly regular amplitude and frequency, and bilateral symmetry.
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Fighting insomnia is just one step! Studies have shown that the thicker the quilt, the more melatonin is secreted...
Time of Update: 2023-01-06
Research process 02 02For the study, researchers selected 26 young, healthy participants, including 15 men and 11 women, to investigate whether the use of a thick quilt (about 12% of body weight) before bed resulted in higher concentrations of melatonin and oxytocin in saliva than light quilt (about 2.
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Neurology—Liyuan Han's team systematically assesses the disease burden of stroke among young adults globally, regionally and nationally
Time of Update: 2023-01-06
Article conclusion and discussion, inspiration and prospectsAlthough age-standardized morbidity, mortality, and DALY rates of ischaemic stroke in young adults declined globally between 1990 and 2019, in low- and middle- and low-SDI regions such as North Africa, the Middle East and Southeast Asia, The burden of ischaemic stroke is still increasing.
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The diagnosis and treatment of choreoa and tardive dyskinesia related to Huntington's disease in adults was explained at this summit forum
Time of Update: 2023-01-06
On October 29, 2022, the first Deuterium Tetrabenazine China-West International Summit Forum was successfully held in Chengdu, where many experts in neurology and psychiatry at home and abroad shared their experience in TD and HD treatment, opening up a smooth life path for more patients.
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Nature: Allowed 9 paralyzed patients to regain the ability to walk, and now the cause is finally understood
Time of Update: 2023-01-06
Link to Grégoire Courtine (right) and Jocelyne Bloch (left): style="caret-color: rgb(255, 0, 0);font-family: , "Microsoft YaHei", sans-serif;color: rgb(136, 136, 136);font-size: 12px;letter-spacing: normal;" _mstmutation="1" _istranslated="1"> open reprint, welcome to forward to Moments and WeChat groups Written byTwo pearsSourceLilac AcademicAs early as 30 years ago, preclinical and clinical studies showed that epidural electrical stimulation (ESS) on the lumbosacral spinal cord restored the ability to walk in patients with spinal cord injury.
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Yu Shuyan's team at Shandong University revealed the molecular mechanism of neuronal intracellular PH imbalance inducing depression
Time of Update: 2023-01-06
Stress-induced reduction of Na+/H+ exchanger isoform 1promotes maladaptation of neuroplasticityand exacerbates depressive behaviors The images in the article are from referencesClick on the blue word to follow usDue to proteins involved in regulating neuronal excitability, the brain is very sensitive to changes in pH, and effective synaptic transmission depends critically on proper pH.