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Sci Transl Med︱ A new mechanism to improve the pathology of Alzheimer's disease
Time of Update: 2021-06-05
The researchers used PACAP to target PAC1R to eliminate tau protein in the postsynaptic compartment of the mouse brain by increasing PKA signaling and enhancing proteasome activity (Figure 4).
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JAMA Neurol: Serum N-acetylglucosamine or an important marker of multiple sclerosis disease progression
Time of Update: 2021-06-04
Compared with the healthy control group and RRMS group, the GlcNAc level of PMS patients was significantly lower (548 nM)HexNAc level and clinical symptoms of MSStudies believe that serum N-acetylglucosamine deficiency or an important biomarker of progressive multiple sclerosis, GlcNAc deficiency may be related to the progressive disease and neurodegeneration of MS patients .
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Translational Psychiatry: Selective serotonin reuptake inhibitors are beneficial for cognition and brain development in patients with 22q11.2 deletion syndrome
Time of Update: 2021-06-04
This retrospective cohort study aimed to determine whether the early treatment of SSRIs in children and adolescents with 22q11DS is related to the long-term effects of cognitive and brain development.
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Alzheimers Dementia: Attention, the fatter a person, the easier it is to become stupid
Time of Update: 2021-06-04
In this way, Adina Zeki Al Hazzouri and others at Columbia University used BMI data from a set of cohorts that spanned the life course to explore the relationship between BMI in early adulthood and the incidence of dementia in later life.
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Nature | A New Breakthrough in Brain-Computer Interaction: Thoughts and Words
Time of Update: 2021-06-04
This brain-computer interaction technology can reach a typing speed of 90 characters per minute, which is equivalent to the typing speed of a normal person playing on a mobile phone, and the accuracy rate after offline automatic correction is as high as 99%.
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Lancet Sub-Journal: Can Internet CBT therapy bring better curative effect to patients with depression?
Time of Update: 2021-06-04
references:Dismantling, optimising, and personalising internet cognitive behavioural therapy for depression: a systematic review and component network meta-analysis using individual participant data.
1016/S2215-0366(21)00077-8Dismantling, optimising, and personalising internet cognitive behavioural therapy for depression: a systematic review and component network meta-analysis using individual participant data.
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Harvard scientists revealed how the key protein of Alzheimer's disease is formed, and is expected to develop new therapies
Time of Update: 2021-06-04
▎Editor of WuXi AppTec's content team recently, researchers from Harvard Medical School and Massachusetts General Hospital (MGH) published a study on Alzheimer's disease in Cell Reports under "Cell" , Uncovered the mystery that has plagued for many years: how the key protein that affects Alzheimer's disease-amyloid beta (Aβ, amyloid beta) is formed in the axons of brain neurons and structures related to neural connections of.
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Identify the causative gene of premature amyotrophic chordosclerosis | "Nature-Medical" paper
Time of Update: 2021-06-04
A clinical discovery report published in Nature-Medical this week, Childhood amyotrophic lateral sclerosis caused by excess sphingolipid synthesis, found that children with severe early-onset amyotrophic lateral sclerosis (ALS) have a rare type of SPTLC1 gene Mutations, this gene encodes a key metabolic molecule responsible for the production of a class of lipids called sphingolipids.
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Neurology: Multiple sclerosis: When fatigue and drowsiness occur in patients, central drowsiness is more likely to occur
Time of Update: 2021-06-04
And let multiple sclerosis patients and healthy control group complete questionnaires about sleep, fatigue, lethargy and depression.
The important significance of this study is that patients with multiple sclerosis often suffer from central sleep deprivation when they experience fatigue and lethargy.
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Neurology: The greater the blood pressure variability, the faster the cognitive decline
Time of Update: 2021-06-04
It was found that large inter-office SBP variability is related to cognitive decline, and is also closely related to cerebrovascular pathology and neurofibrillary tangles.
It was found that large inter-office SBP variability is related to cognitive decline, and is also closely related to cerebrovascular pathology and neurofibrillary tangles.
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Express | Obtained FDA priority review qualification, the world's first treatment for "Stone Man" is expected to be born
Time of Update: 2021-06-04
S. FDA has accepted the company’s New Drug Application (NDA) for the selective RARγ agonist palovarotene for the treatment of a rare genetic disease with progressive muscular ossification (Fibrodysplasia ossificans progressiva, FOP).
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IEEE trans: Application of multivariate analysis of Kinect joint motion data in Parkinson's disease
Time of Update: 2021-06-04
In this study, we used Kinect to record joint movement data of PD patients and healthy subjects from sitting to standing.
, "Multivariate Analysis of Joint Motion Data by Kinect: Application to Parkinson's Disease," in IEEE Transactions on Neural Systems and Rehabilitation Engineering , vol.
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Frontier | Can't stop eating while losing weight?
Time of Update: 2021-06-04
The neural circuit composed of a group of dopamine-producing neurons DA-VTA and the downstream neurons DRD1-LPBN in the hindbrain can strongly inhibit food intake by triggering the feeling of satiety in mice.
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The lower the level of T3 and FT3, the more severe the cognitive impairment in stroke patients? Shijiazhuang People’s Hospital publishes important correlation analysis丨Stroke "Miscellaneous" Talk · Issue 3
Time of Update: 2021-06-04
To clarify the correlation between the levels of triiodothyronine (T3) and free triiodothyronine (FT3) in thyroid hormones and the cognitive function of stroke patients, Li Hong, Ma Jiang, Shi Wanying and other scholars from Shijiazhuang People’s Hospital Published important correlation studies in our journal to explore potential clinical predictive indicators that may affect cognitive function, and provide references for cognitive function rehabilitation.
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The classic has been subverted again?
Time of Update: 2021-06-04
On May 28, 2021, the Nachum Ulanovsky research team of the Weizmann Institute of Science in Israel recorded the activity of neurons at the location of fruit bats in a 200-meter-long flight area in a field environment, revealing an unknown and efficient The method of encoding spatial information: the firing method of a single neuron with multiple regions in a variable range.
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BMJ: Controversy over COVID-19 mRNA vaccination in patients with multiple sclerosis treated with DMT
Time of Update: 2021-06-04
In Neurological Disorders magazine published by Achiron et al Therapeutic Advances article "Humoral Immune the Response to COVID-19 mRNA Vaccine in patients with Multiple sclerosis Treated with High-efficacy disease-modifying Therapies," COVID-19 The authors used the spike protein-based anti-prickly Serology tested the SARS-CoV-2 IgG response in a group of multiple sclerosis (MS) patients who received three different types of disease therapies (DMTs), including Cladribine (n = 23), Ogilvy & Mather Lizumab (n = 44) and fingolimod (n = 26).
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June 1st: The helmet law is implemented nationwide, why do you need to wear a helmet well: People with head injuries are more likely to become "silly" and there are many "sequelae"
Time of Update: 2021-06-04
Studies have found that many people with head injury will suffer from cognitive dysfunction, and the incidence of dementia will increase.
Studies have found that many people with head injury will suffer from cognitive dysfunction, and the incidence of dementia will increase.
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Brain Connect: Conductance measurement has predictive potential for brain structure changes in aging and Alzheimer's disease
Time of Update: 2021-06-04
Blood vesselThe analysis of the study showed the expected trends of average conductance and age and cognitive scores, significant age predictors in aging data, and regional effects centered on the subcortical area, cingulate, and temporal cortex.
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JAMA Neurol: Clinical characteristics study of Japanese LRP12-CGG repeat expansion patients with distal ophthalmopharyngeal myopathy
Time of Update: 2021-06-04
63 Cases (98%) had dysphagia or joint dysfunction, 62 cases (97%) had ptosis, and 63 cases (98%) had dysphagia or joint dysfunctionCharacteristics of muscle influence in OPDM patientsStudies believe that the OPDM-LRP12 subtype is the most common subtype of distal ophthalmopharyngeal myopathy in Japan, which is characterized by weakness and distal myopathy .
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Nature: Neuronal activity promotes tumor growth, which is actually related to it
Time of Update: 2021-06-04
In order to study the effect of neuronal activity on the growth of low-grade glioma and the formation of glioma, they used a type of Nf1-OPG transgenic mice called poorly differentiated optic neuroma, which has a high tumor incidence.
