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Brain Connect: Conductance measurement has predictive potential for brain structure changes in aging and Alzheimer's disease

 Last Update: 2021-06-04
 Source: Internet
 Author: User

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The structural connections of the white matter axon tracts reflect the physical connections of the brain.

diagnosis

Aina Frau-Pascual uses the recently proposed quantitative measurement of structural connectivity obtained from diffusion magnetic resonance imaging, which explains the direct and indirect ways to quantify brain connectivity in dementia.

The study analyzed data from the second phase of the Alzheimer's disease neuroimaging project and the third edition of the imaging research open series data set to obtain relevant information about brain changes in AD patients.

The demographic data of the AD dataset.

Blood vessel

The analysis of the study showed the expected trends of average conductance and age and cognitive scores, significant age predictors in aging data, and regional effects centered on the subcortical area, cingulate, and temporal cortex.

The correlation between average conductance and age, CDR and MMSE cognitive scores, CDR color coding is 0 (blue), 0.

The study models structural connectivity as electrical conductivity, which is calculated as the weighted sum of all possible paths between two regions based on the information given by the diffusion tensor.

In a cohort of 272 subjects in ADNI-2 (top) and OASIS-3 (bottom) populations, the insula/caudate body in the left and right hemispheres was negatively correlated with the central anterior gyrus/entorhinal cortex structure connection.

Conductivity measurement has predictive potential, especially for age.

Frau-Pascual A, Augustinack J, Varadarajan D, et al.

Frau-Pascual A, Augustinack J, Varadarajan D, et al.
Conductance-Based Structural Brain Connectivity in Aging and Dementia [published online ahead of print, 2021 May 27].
Brain Connect .
2021;10.
1089/brain.
2020.
0903.
doi:10.
1089 /brain.
2020.
0903 Frau-Pascual A, Augustinack J, Varadarajan D, et al.
Conductance-Based Structural Brain Connectivity in Aging and Dementia [published online ahead of print, 2021 May 27].
Brain Connect .
2021;10.
1089/brain.
2020.
0903 .
doi:10.
1089/brain.
2020.
0903 Brain Connect

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