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Alzheimer's Research & Therapy: Abnormal connection of default network and significant network function in patients with decreased subjective cognitive function predicts dementia
Time of Update: 2021-06-04
The degree of SCD predicts the default network and significant network node internal and node Changes in FC between changes in the brain are the basis for perceptual decline, and before the assessment can detect cognitive deficits, it may be a sensitive marker of neonatal dementia.
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Nat Med: A single gene mutation may cause many of us to grow 30 pounds of fat!
Time of Update: 2021-06-04
Given the definite association between MC4R LoF mutations and obesity complications such as type 2 diabetes and coronary artery disease, this has important clinical implications for the long-term health of individual carriers, who, on average, may carry ~15 kg of extra fat Enter adult life.
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May Neurology Guidelines and Consensus, one article is included in the bag|Guide Consensus
Time of Update: 2021-06-04
cn/guideline/23391 Recommended articles: 2021 emergency diagnosis and treatment guidelines for vertigo released, 3 minutes quick reading 03 Perforator atherosclerosis Chinese expert consensus on perforator atherosclerosis BAD is a common type of acute ischemic stroke.
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Neurology: The cerebellum has extraordinary significance in Parkinson's disease
Time of Update: 2021-06-04
The role of the cerebellum in the non-motor area of Parkinson’s disease is confirmed, and the different but overlapping metabolic-related patterns indicate the involvement of the cerebellum-thalamus-striatum-cortex circuit.
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Alzheimers Dementia: Neurofilament light chain protein in the blood, which can effectively predict cognitive decline
Time of Update: 2021-06-04
In the Obj-SCD and MCI groups, compared with the CN group, higher NFL levels predicted a faster decline in memory and preclinical AD composite scores.
Compared with the CN group, higher NFL levels indicate a faster decline in memory and preclinical AD composite scores.
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Sub-Journal of "Nature": Demystifying the cause of death of specific neurons in AD patients!
Time of Update: 2021-06-04
Recently, a new study published in the journal Nature Neuroscience showed that the selective degeneration of neurons is related to the regulation of intracellular immune response by apolipoprotein E (ApoE) [2].
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This virus has been latent in the human genome for thousands of years, and for the first time it has been proved that its activation can affect brain development!
Time of Update: 2021-06-04
▲Schematic diagram of the mechanism of this study: activation of HERV-K (HML-2) leads to excessive activation of genes such as NTRK3, impairing the differentiation of cerebral cortex neurons and cortical development (picture source: reference [1]) This study also suggests that healthy During brain development, epigenetic mechanisms keep HERV under control.
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Nat Med: Excessive sphingolipid synthesis can cause amyotrophic lateral sclerosis in children
Time of Update: 2021-06-04
It is worth noting that by comparing the formation of SPTLC1 mutants, the researchers found that the conversion of the amino acid altered by SPT from serine to alanine would lead to an increase in the level of deoxysphingolipids and manifested as hereditary sensory and autonomic neuropathy.
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Translational Psychiatry: High-sugar and high-fat diet affects the metabolism of neurotransmitters, changes the intestinal microbiota and affects brain function
Time of Update: 2021-06-04
In mice fed a high-sugar and high-fat diet for 4 months, bacterial imbalance affects neurotransmitter metabolism by targeting the gut-brain axis.
In mice fed a high-sugar and high-fat diet for 4 months, bacterial imbalance affects neurotransmitter metabolism by targeting the gut-brain axis.
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Hypertension: The blood pressure determining parameter of white matter hyperintensity and microstructure damage
Time of Update: 2021-06-04
CardiovascularThe researchers determined the linear correlation between neuroimaging markers (white matter hyperintensity [WMH] volume and diffusion imaging index) and mean arterial pressure and pulse pressure (PP), including uncorrected and corrected age, gender, and cardiovascular Risk factors, antihypertensive drugs, blood pressure sources and assessment centers.
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Nature: Don't rush to remove the plaques in the brains of patients with Alzheimer's disease!
Time of Update: 2021-06-04
On the one hand, this study may partially explain the failure of phase 3 clinical trials of AD treatment drugs for Aβ plaques (which can break down dense plaques without changing the production of Aβ polypeptides), such as Aducanumab and Crenezumab.
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Scientists reveal the dynamic change process of hippocampus cells caused by spatial location
Time of Update: 2021-06-04
CA1 pyramidal neurons quickly become PFs during the exploration of new environments, but it has always been a mystery whether CA3, which is the main input of CA1, has similar rapid dynamics.
Researchers use VR virtual technology to place the mice in an unfamiliar and familiar environment.
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NBE | Wang Lihong and others develop the human brain three-dimensional panoramic fast scanning photoacoustic tomography-1K3D-fPACT
Time of Update: 2021-06-04
Among them, blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI) is used as the mainstream technology of non-invasive brain functional imaging in scientific research and clinical applications.
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The relationship between the duration of type 2 diabetes and the risk of dementia
Time of Update: 2021-06-02
This article is from the NEJM Journal Watch (NEJM Journal Watch) Duration of Type 2 Diabetes and Risk for Dementia.
Commenting on these results clarified the role of duration of type 2 diabetes in the onset of dementia.
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Targeting microglia, can Alector Alzheimer's disease antibody enter Phase 2 clinical trials, can it escape the fate of "safe and ineffective"?
Time of Update: 2021-06-02
Alector chose to develop agonistic TREM2 antibodies to activate disease-related microglia, enhance the phagocytosis of Aβ, clear plaques, and restore neuronal function.
Shoutang Wang et al, Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model, J.
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What to eat is good for the brain?
Time of Update: 2021-06-02
Tommaso Ballarini, the corresponding author of the 123RF study and the German Center for Neurodegenerative Diseases (DZNE) pointed out: "Although more research is needed to explore the mechanism by which the Mediterranean diet protects the brain from protein accumulation and loss of brain function.
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The diagnosis of peripheral neuropathy is clear in this article!
Time of Update: 2021-06-02
For peripheral neuropathy, we must first ask the patient's onset process and past medical history in detail, and then perform a detailed physical examination on this basis to make a preliminary judgment on the diagnosis.
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Cell Stem Cell | Fibroblasts have great powers: Simulate Alzheimer's disease and have their own aging characteristics
Time of Update: 2021-06-02
These results suggest that iNs directly transformed from fibroblasts can better simulate neurons in the aging brain and can be used as an in vitro research model for aging-related AD.
By comparison, the authors found that unlike iNs, iPSC-iNs neurons induced by iPSC lost the disease-related transcriptome characteristics of aging AD patients.
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A 52-year-old man with sudden dyspnea, chest pain and seizures
Time of Update: 2021-06-02
The measurement of a formal echocardiographic study conducted on the first day showed that the left ventricular ejection fraction was reduced to 45%, the early diastolic ratio was significantly increased to 20.
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How to choose anti-epileptic drugs for this seizure form that often leads to sudden epilepsy death?
Time of Update: 2021-06-02
*It is only for medical professionals to read and refer to a systematic review of the efficacy of antiepileptic drugs in the treatment of focal progression to bilateral tonic-clonic seizures.
