The relationship between the duration of type 2 diabetes and the risk of dementia

This article is from the NEJM Journal Watch (NEJM Journal Watch) Duration of Type 2 Diabetes and Risk for Dementia.
The relationship between the duration of type 2 diabetes and the risk of dementia.
Comment by Thomas L.
Schwenk, MD, who had diabetes for more than 10 years and at 70 years old The risk of dementia is doubled.

The estimated value of the strength of the association between type 2 diabetes and dementia is currently uncertain, probably because most analyses did not consider the duration of diabetes.

In this population-based prospective cohort study, the researchers used a British database to identify about 10,000 people (age range, 35 to 55 years old) who were included in the database in 1982 and received a median follow-up of 32 years.
, 1,710 people have type 2 diabetes and 639 people have dementia.

At the age of 70, among people without diabetes, the incidence of dementia was 9 cases per 1,000 person-years; among people with diabetes ≤5 years ago, 6-10 years ago, and >10 years ago, the incidence of dementia was respectively 10 cases, 13 cases and 19 cases per 1,000 person-years.

The adjusted analysis confirms that the risk of dementia is doubled in people with diabetes> 10 years ago.

Commenting on these results clarified the role of duration of type 2 diabetes in the onset of dementia.

In addition to the obvious significance of the importance of preventing diabetes, as the age of onset of diabetes is getting younger, clinicians should pay more attention to the diagnosis of dementia.

Commented articles Barbiellini Amidei C et al.
Association between age at diabetes onset and subsequent risk of dementia.
JAMA 2021 Apr 27; 325:1640.
(https://doi.
org/10.
1001/jama.
2021.
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