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A 52-year-old man with sudden dyspnea, chest pain and seizures
Time of Update: 2021-06-02
The measurement of a formal echocardiographic study conducted on the first day showed that the left ventricular ejection fraction was reduced to 45%, the early diastolic ratio was significantly increased to 20.
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Sci Adv | Explore the neural mechanism of "pain first"
Time of Update: 2021-06-02
Studies of nerve cells in the parabrachial nucleus that project to the central amygdala (CeA) have shown that these nerve cells encode fear responses that include pain, and they can reduce appetite when activated (Campos et al.
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Why are female athletes more prone to concussions?
Time of Update: 2021-06-02
Original author: Katharine Sanderson The data on the incidence and causes of concussion among American high school athletes show surprising gender differences.
But this view lacks conclusive data support-the head of the study, Willie Stewart, a neuropathologist at the University of Glasgow in the UK, said, "There hasn't been much research on female athletes.
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Science | Mosaic Expression in Synapses: Revealing the Molecular Mechanism of X-Linked PCDH19 Mutation Disease
Time of Update: 2021-06-02
In order to solve the mystery of this problem, the Hisashi Umemori research group of Harvard Medical School in the United States published a research paper in Science, entitled Female-specific synaptic dysfunction and cognitive impairment in a mouse model of PCDH19 disorder, which revealed that the PCHD19 mutation is in heterozygotes.
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Bluebird's application for gene therapy for childhood encephalopathy is actively recommended by CHMP | Yimai Meng broke the news
Time of Update: 2021-06-02
The potential and challenges of stem cells Yimai Meng broke the news ★ Gu Yuchun, Chief Scientist of Chengnuo Medical: Continue to lead, China's first "spot type" allogeneic source CAR-NK is about to enter the clinical stageFengke Transcend May 24, 2021 / Medical EMedClub News/--Today, Bluebird bio (Bluebird bio) treatment of cerebral adrenal leukodystrophy (CALD) gene therapy Skysona (elivaldogene autotemcel, eli-cel) marketing authorization has been granted by the European Medicines Agency for human drugs The committee’s positive recommendation.
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Warfarin or new oral anticoagulant: How to choose a stroke prevention strategy for patients with high-risk atrial fibrillation?
Time of Update: 2021-06-02
High-risk groups for atrial fibrillation include patients with end-stage renal failure (ESRD, including patients on dialysis), elderly patients (such as those over 80 years of age with multiple risk factors for bleeding), patients with dementia or patients who require long-term care, and previous intracranial hemorrhage (ICH) or patients with recent acute bleeding (such as gastrointestinal bleeding), patients with acute ischemic stroke, and patients with intracardiac thrombosis.
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A case, take you to a comprehensive understanding of the status of migraine | case study
Time of Update: 2021-06-02
2 Definitions and diagnostic criteria According to the third edition of the International Classification of Headache Diseases (ICHD-3), Status migrainosus (SM) refers to "debilitating migraine attacks that last more than 72 hours" [1], similar In "status epilepticus".
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Do you still dare to watch TV?
Time of Update: 2021-06-02
On May 21, Beijing time, three studies published at the 2021 Epidemiology, Prevention, Life> Researchers found that during early adulthood and middle age, the longer you watch TV every day, the faster the brain ages, and the greater the risk of cognitive decline in later life.
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How to treat chronic insomnia in adults?
Time of Update: 2021-06-02
Recommendations The following recommendations are intended to provide references for clinicians to choose specific behavioral and psychological treatments for the treatment of adult chronic insomnia disorders.
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Don't ignore these atypical TIA symptoms!
Time of Update: 2021-06-02
Figure 5: 10-year risk of all major vascular events in patients with atypical TIA, classic TIA, and mild ischemic stroke 3.
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Alzheimer's Dementia︱ The latest scientific hypothesis!
Time of Update: 2021-06-01
Studies have shown that the activation of JNK is not only related to the hyperphosphorylation of tau protein in AD and other neurodegenerative diseases, but also involved in the production and accumulation of Aβ [6-8].
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I don’t know how to distinguish between silly, and there are so many types of multiple sclerosis, how to choose the medicine?
Time of Update: 2021-06-01
Figure 4: Results of the core TOPIC study of teriflunomide in the treatment of CIS▌ RRMS In patients with general active RRMS, a number of core studies such as TEMSO and TOWER studies have confirmed that teriflunomide can control the development of the disease in multiple ways, including reducing the recurrence rate , Persistent disability progression risk and MRI lesion activity, and slow down brain atrophy.
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Lancet Sub-Journal: Can you detect a stroke with just a small piece of equipment around your waist?
Time of Update: 2021-06-01
references:Systematic monitoring for detection of atrial fibrillation in patients with acute ischaemic stroke (MonDAFIS): a randomised, open-label, multicentre study.
1016/S1474-4422(21)00067-3Systematic monitoring for detection of atrial fibrillation in patients with acute ischaemic stroke (MonDAFIS): a randomised, open-label, multicentre study.
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Professor Ye Xinchun, Department of Neurology, Affiliated Hospital of Xuzhou Medical University, passed away unfortunately at the age of 41
Time of Update: 2021-06-01
On May 24, 2021, teacher Ye Xinchun, Department of Neurology, Affiliated Hospital of Xuzhou Medical University, died of sudden illness.
Ye Xinchun is a doctor of medicine, a postdoctoral fellow in the United States, deputy director of the Stroke Center of Xu Medical Affiliated Hospital , deputy chief physician, associate professor, and master's supervisor.
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Nature Sub-Journal: The Neural Circuit Mechanism of Long-term Fear Memory Dissipation
Time of Update: 2021-06-01
This shows that the NRe brain area regulates the dissipating process of long-term fear memory in both directions.
The closed-loop light activation of the NRe→BLA neural circuit can reduce the expression of fear memory in mice during the dissipating process of long-term fear memory.
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Stroke: Features of focal cerebral artery disease in children
Time of Update: 2021-06-01
The researchers reviewed the electronic health record data, including the results of neuroimaging examinations, and determined the outcome of stroke in children at 1 year of age as the primary clinical endpoint.
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Nature Medicine: Plasma phosphorylated tau protein combined with simple cognitive tests and APOE genotyping can improve the predictive ability of Alzheimer's dementia
Time of Update: 2021-06-01
The model selection and performance of ADNI predicting AD dementia within 4 years were compared with the model selected in BioFINDER.
Within 4 years, plasma P-tau217 accurately predicted AD in BioFINDER ( area under the curve (AUC) = 0.
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Nature Neuroscience: The rice is enough, it depends on how the brain decides to be hungry or not?
Time of Update: 2021-06-01
In the state of persistent hunger or thirst, photo-inhibition of mPFC neurons does not affect the index of food or water preference, the average reaction time and other indicators of the mice.
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Science | Achieve Cell-Resolution Integrated Stress Response State Whole Brain Imaging
Time of Update: 2021-06-01
In order to specifically analyze this mechanism, Science recently published a research paper titled Cholinergic neurons constitutively engage the ISR for dopamine modulation and skill learning in mice, and reported the SPOTlight two-color report developed by the Nicole Calakos group of Duke University Medical Center.
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JAMA Neurol: 5 years after Zolgensma treatment, patients with spinal muscular atrophy can still get long-term clinical remission
Time of Update: 2021-06-01
Five years after receiving Zolgensma treatment, the clinical symptoms of type 1 SMA patients have been relieved for a long time, and they have good long-term safety.
