Neurology: Multiple sclerosis: When fatigue and drowsiness occur in patients, central drowsiness is more likely to occur

Fatigue is one of the most common symptoms of multiple sclerosis (MS), affecting up to 80% of patients, and more than half of them believe that fatigue is their most troublesome symptom.

Some studies have shown that fatigue increases with the duration of disability and illness.

At the beginning of the disease, the frequency of sleep disturbances appeared to be similar in multiple sclerosis patients and healthy controls.

In this way, Anne-Laure Dubessy and others of Saint Antoine Hospital in France, we recruited mildly disabled multiple sclerosis patients with fatigue and without fatigue, and divided the former into 2 subgroups: fatigue and lethargy and fatigue But no drowsiness.

And let multiple sclerosis patients and healthy control group complete questionnaires about sleep, fatigue, lethargy and depression.

The patients were divided into 3 groups (fatigue and lethargy; fatigue and no lethargy; neither fatigue nor lethargy).

Among 44 patients with multiple sclerosis, 19 (43.

Compared with the 24 controls, patients with fatigue and lethargy had a higher percentage of rapid eye movement sleep, lower arousal indicators, and shorter average daytime sleep delays.

Restless legs syndrome, periodic leg movements, and sleep apnea had similar frequencies between the groups.

Compared with patients without insomnia, patients with central insomnia are younger and more lethargic, but their fatigue, disability, depression, cognitive ability and human leukocyte antigen DQB1*0602 genotype frequency are similar.

The severity of fatigue increases with the increase in depression scores, the increase in the severity of sleepiness, and the decrease in sleep performance.

Original source: