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▎Edit by WuXi AppTec content team I want to lose weight! But when eating, I looked left and right.
Milk tea, cakes, crayfish, cheese balls, snail noodles.
.
.
As a result, I always defeated the food.
I kept eating, and I didn't feel full.
As a result, you are still eating when you are full, your intake is more than you need, and your weight is not lost at all, but you are also squeezing up.
The weight loss plan is of course a failure.
Are you also struggling in this cycle? Satiety is as important as appetite.
In a study recently published in Science Advances, researchers at Baylor College of Medicine discovered that a little-known brain circuit helps to precisely regulate food.
intake.
The neural circuit composed of a group of dopamine-producing neurons DA-VTA and the downstream neurons DRD1-LPBN in the hindbrain can strongly inhibit food intake by triggering the feeling of satiety in mice.
They also found that this special circuit can be activated by the drug methylphenidate (MPH), which may help people control their weight and achieve significant weight loss.
MPH was previously approved by the US FDA to relieve attention deficit disorder.
The research team tested the activity of the two groups of neurons when the mice were eating.
They observed that the activity of DA-VTA neurons increased rapidly before the mice stopped eating.
When the activity of these neurons is inhibited by genetic engineering, the mice will prolong their food intake time and greatly increase their food intake.
This suggests that inhibiting this circuit prevented the mice from feeling full.
They also found that by enhancing the activity of DRD1-LPBN neurons that receive DA-VTA neuronal signals, they can effectively produce a satiety response and stop the mice from eating.
MPH can regulate this circuit, thereby affecting the food intake of mice to achieve effective weight loss.
▲MPH can significantly reduce the amount of food eaten by mice (red) by activating DRD1-LPBN neurons (picture source: reference [1]) Dr.
Qi Wu, the corresponding author of this study, said: "We found that MPH can strengthen this dopamine The supported new circuit can inhibit mice’s food intake and lead to weight loss, which indicates the unexpected potential application of MPH and derivatives in solving obesity.
It is also meaningful for the future development of precision medicine based on this circuit, which can provide higher Safe and effective weight loss therapy.
"▲ Dr.
Qi Wu of Baylor College of Medicine (picture source: Baylor College of Medicine official website) "Researchers have proposed to use other brain circuits to regulate food intake, but this circuit we found is the first One that regulates food intake through dopamine signals.
” Dr.
Yong Han, the first author of this study, said, “Our new research shows that dopamine was previously thought to be a chemical signal that regulates motivation and pleasure, and a dopamine-generating neuron The circuit plays a new role in controlling eating by dynamically adjusting the feeling of fullness.
Many people are struggling to control weight, often eating more than their body needs, which leads to weight gain, obesity and increased heart disease, stroke and The risk of serious related diseases such as type 2 diabetes.
Through continuous in-depth understanding of brain activity during eating, we hope that our findings will one day help people better control their weight.
"Reference: [1] Han, et al.
, (2021) A hindbrain dopaminergic neural circuit prevents weight gain by reinforcing food satiation.
Science Advances, DOI: 10.
1126/sciadv.
abf8719[2] This brain circuit signals when to stop eating ; could regulate it help with obesity.
Retrieved May 26, 2021, from https://medicalxpress.
com/news/2021-05-brain-circuit-obesity.
html Recommended.
If you need guidance on the treatment plan, please go to a regular hospital for treatment.
Milk tea, cakes, crayfish, cheese balls, snail noodles.
.
.
As a result, I always defeated the food.
I kept eating, and I didn't feel full.
As a result, you are still eating when you are full, your intake is more than you need, and your weight is not lost at all, but you are also squeezing up.
The weight loss plan is of course a failure.
Are you also struggling in this cycle? Satiety is as important as appetite.
In a study recently published in Science Advances, researchers at Baylor College of Medicine discovered that a little-known brain circuit helps to precisely regulate food.
intake.
The neural circuit composed of a group of dopamine-producing neurons DA-VTA and the downstream neurons DRD1-LPBN in the hindbrain can strongly inhibit food intake by triggering the feeling of satiety in mice.
They also found that this special circuit can be activated by the drug methylphenidate (MPH), which may help people control their weight and achieve significant weight loss.
MPH was previously approved by the US FDA to relieve attention deficit disorder.
The research team tested the activity of the two groups of neurons when the mice were eating.
They observed that the activity of DA-VTA neurons increased rapidly before the mice stopped eating.
When the activity of these neurons is inhibited by genetic engineering, the mice will prolong their food intake time and greatly increase their food intake.
This suggests that inhibiting this circuit prevented the mice from feeling full.
They also found that by enhancing the activity of DRD1-LPBN neurons that receive DA-VTA neuronal signals, they can effectively produce a satiety response and stop the mice from eating.
MPH can regulate this circuit, thereby affecting the food intake of mice to achieve effective weight loss.
▲MPH can significantly reduce the amount of food eaten by mice (red) by activating DRD1-LPBN neurons (picture source: reference [1]) Dr.
Qi Wu, the corresponding author of this study, said: "We found that MPH can strengthen this dopamine The supported new circuit can inhibit mice’s food intake and lead to weight loss, which indicates the unexpected potential application of MPH and derivatives in solving obesity.
It is also meaningful for the future development of precision medicine based on this circuit, which can provide higher Safe and effective weight loss therapy.
"▲ Dr.
Qi Wu of Baylor College of Medicine (picture source: Baylor College of Medicine official website) "Researchers have proposed to use other brain circuits to regulate food intake, but this circuit we found is the first One that regulates food intake through dopamine signals.
” Dr.
Yong Han, the first author of this study, said, “Our new research shows that dopamine was previously thought to be a chemical signal that regulates motivation and pleasure, and a dopamine-generating neuron The circuit plays a new role in controlling eating by dynamically adjusting the feeling of fullness.
Many people are struggling to control weight, often eating more than their body needs, which leads to weight gain, obesity and increased heart disease, stroke and The risk of serious related diseases such as type 2 diabetes.
Through continuous in-depth understanding of brain activity during eating, we hope that our findings will one day help people better control their weight.
"Reference: [1] Han, et al.
, (2021) A hindbrain dopaminergic neural circuit prevents weight gain by reinforcing food satiation.
Science Advances, DOI: 10.
1126/sciadv.
abf8719[2] This brain circuit signals when to stop eating ; could regulate it help with obesity.
Retrieved May 26, 2021, from https://medicalxpress.
com/news/2021-05-brain-circuit-obesity.
html Recommended.
If you need guidance on the treatment plan, please go to a regular hospital for treatment.
