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Fudan Gu Yu's team reveals the developmental mechanism of visual experience that regulates the variability and stability of neuronal responses in both eyes Cell Press paper express
Time of Update: 2022-09-21
Recently, The Team of Gu Yu of Fudan University published a research paper entitled "Binocular visual experience drives the maturation of response variability and reliability in the visual cortex" in iScience, an interdisciplinary journal under Cell Press.
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Science Sub-Journal: An Zhiqiang's team develops novel agonist antibodies to treat Alzheimer's disease
Time of Update: 2022-09-21
The team developed a tetravalent TREM2 agonist antibody that has shown therapeutic effects in both in vitro and in mouse models of Alzheimer's disease, including increasing microglia-mediated phagocytosis and improving animal cognitive abilities.
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Infection accelerates the progression of Alzheimer's disease! Neurology bulls come up with new hypotheses
Time of Update: 2022-09-21
*For medical professionals onlyWhen Eros Alzheimer's reception in 1901 was of a woman named August Dent who had been admitted to a psychiatric hospital for memory impairment and gibberish, he probably
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Neuron: The Ju Huang research team at Shanghai Jiao Tong University reveals reward neural circuits for repeated nail-biting or skin behaviors
Time of Update: 2022-09-21
Figure 1: MPL-SST-enabled neurons regulate self-grooming behavior2MPL-SST can neuronal upper and lower brain regionsRetrograde tracing virus experiments have found that MPL is mainly received from the central amygdala (CeA), terminal bed nucleus (BNST), ventral lateral midbrain periosteal gray matter (vlPAG), hypothalamic paraventricular nucleus (PVN), hypothalamus (IC), and auditory cortex (Au).
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Ann Neurol-Tengfei Guo's research group revealed the association between tau pathology-mediated synaptic damage and neurodegeneration and cognitive decline
Time of Update: 2022-09-21
On September 3, 2022, Guo Tengfei's research group at the Institute of Biomedical Engineering of Shenzhen Bay Laboratory published an article entitled "Association of presynaptic loss with Alzheimer's disease and cognitive decline" in the Annals of Neurology, elaborating on CSF The changes of GAP43 in different clinical and pathological stages of AD, and its correlation with Aβ, tau, neurodegeneration, and cognitive decline, confirm the important role of tau pathologically induced synaptic damage in AD neurodegeneration and cognitive decline.
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Nature: Tan Xiaojun et al. reveal a new repair mechanism of lysosomals
Time of Update: 2022-09-21
Thesis link: open reprint welcome to forward to the circle of friends and WeChat group Lysosomal damage is a marker of aging and the occurrence of a variety of diseases in the body, and studies have shown that the lifespan of cells depends on lysosomal function, and lysosomals can be positioned as the central cell hub that controls aging.
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Nature sub-journal: Cheng Wenwen et al. draw a map of the posterior brain neurons that control diet to help develop better weight loss drugs
Time of Update: 2022-09-21
The researchers linked this information to a map of neural circuits in the brainstem and built models of posterior brain circuits that control food intake and energy homeostasis, providing important clues for further research and development of drugs that treat obesity with fewer side effects.
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The clinical significance of lumbar puncture of cerebrospinal fluid, read in one article
Time of Update: 2022-09-21
Decreased intracranial pressure: < 80mmH2O, which is more common in low cranial pressure, dehydration, subarachnoid obstruction of the spinal cord, cerebrospinal fluid leakage, etc.
Decreased intracranial pressure: < 80mmH2O, which is more common in low cranial pressure, dehydration, subarachnoid obstruction of the spinal cord, cerebrospinal fluid leakage, etc.
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The Nature Review's long review analyzes how intestinal-related factors affect the incidence and treatment of Parkinson's disease?
Time of Update: 2022-09-21
*For medical professionals onlyMore than 200 years ago, British surgeon James Parkinson published a paper on "tremor paralysis", 60 years later, in his honor, the disease was named "Parkinson's diseas
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Nature sub-journal: Neurons on the same day are more likely to "advance and retreat"
Time of Update: 2022-09-21
Recently, in a new study published in Nature Neuroscience, a team of researchers from the Grossman School of Medicine at New York University found that whether awake or asleep, neurons with the same "birthday" showed unique synergistic activity in different brain states throughout the adulthood of mice compared to hippocampal neurons that were "born" on different days.
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The brain is cut into pieces and regenerated, and scientists finally see how it does it
Time of Update: 2022-09-21
So, is it the neural stem cells of the reaEGC subtype that help the salamander regenerate neurons?To confirm this hypothesis, the scientists looked more closely at the salamander terminal brain 15 days after the injury.
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Mol Metab:GLP-1 improves the ability of astrocytes to support neurons by promoting aerobic glycolysis in Alzheimer's disease
Time of Update: 2022-09-20
Figure 3 GLP-1 improves aerobic glycolysis in 5×FAD mice and relieves oxidative stress in the cortex(A-D) analysis of corticolytic levels in three groups, relative expression of glycolytic enzymes detected by Western blotting (A); Glycolysis of lactic acid (B) and NAD+ (C-D).
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A new roundup read: Adult hippocampal neurogenesis in major depression and Alzheimer's disease
Time of Update: 2022-09-20
Few studies have explored this possible interaction, but autopsy analysis of human brain tissue suggests that the use of SSRIs to treat depression is associated with an increase in the number of DCX cells in patients with Lewy body dementia, indicating increased neurogenic activity.
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Chen Huajiang, Long March Hospital Affiliated to naval military medical university: Sensory nerve communication intervertebral disc regulates its extracellular matrix metabolism homeostasis
Time of Update: 2022-09-20
In this study, it is found that in addition to being a passive pain transmission "receptor", the sensory nerve can also be used as a "regulator", actively secreting neuropeptides to regulate the function of nucleus pulposus cells in the intervertebral disc, affecting the metabolism of the extracellular matrix of the intervertebral disc, and participating in the occurrence and development of disc degeneration.
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Science PD Mechanism New Discovery: GPNMB drives pathological progression by promoting α-syn internalization
Time of Update: 2022-09-15
Multiple GWASs have linked chromosome 7 loci (rs199347) to PD, combined with GTEx databases [1, 2] and co-localization analysis, and the authors found that GPNMB exhibited the greatest overlap between PD risk and eQTL effects.
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Stroke: Rosuvastatin significantly slows the progression of atherosclerosis! Another proof of ASCVD prevention
Time of Update: 2022-09-15
Figure 1 The study, published in the Stroke study, confirms that for Chinese populations of subclinical atherosclerosis at low risk of ischemic cardiovascular disease (ICVD), rosuvastatin 20 mg/day can significantly slow the progression of carotid intimal media thickness (CIMT) after 2 years of treatment.
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Science sub-journal: Analysis of the neural coding mechanism under the social defects of mice with autism of "like the new and not tired of the old"
Time of Update: 2022-09-15
Social behavior is the basis for the survival and development of individuals and human society. There is no definitive answer to the scientific question of how the brain encodes information about soci
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Interview with Professor Peng Dantao: The current situation and progress of cognitive impairment in the elderly
Time of Update: 2022-09-15
With the development of economy and science and technology, the aging phenomenon in China is very serious. Along with this is a series of diseases related to aging, such as cognitive impairment in old
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Unravel the mystery of brain regeneration! The cover of "Science" is published in 4 articles, analyzing the key processes of brain evolution
Time of Update: 2022-09-15
The research team conducted a transcriptomic analysis of neuronal evolution in different vertebrates (Image source: References [1]), but in the latest study, by comparing high-resolution maps, the team observed differences in cell types in almost all brain regions.
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Sci Adv Metastat: An axis mechanism that sets normal body weight and blood sugar
Time of Update: 2022-09-15
Metabolic syndromes such as diabetes and cardiovascular disease caused by obesity and obesity are common diseases that plague modern society, and metabolic disorders are common causes of obesity and m
