Ann Neurol-Tengfei Guo's research group revealed the association between tau pathology-mediated synaptic damage and neurodegeneration and cognitive decline

Synaptic damage and dysfunction are closely related to the occurrence and development of AD, and a large number of synaptic losses are present in the brain of patients with AD, which may be involved in the process of subsequent neurodegeneration and cognitive dysfunction [3, 4].

On September 3, 2022, Guo Tengfei's research group at the Institute of Biomedical Engineering of Shenzhen Bay Laboratory published an article entitled "Association of presynaptic loss with Alzheimer's disease and cognitive decline" in the Annals of Neurology, elaborating on CSF The changes of GAP43 in different clinical and pathological stages of AD, and its correlation with Aβ, tau, neurodegeneration, and cognitive decline, confirm the important role

Original link: https://onlinelibrary.

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