Chen Huajiang, Long March Hospital Affiliated to naval military medical university: Sensory nerve communication intervertebral disc regulates its extracellular matrix metabolism homeostasis

Innovation: The relationship between the sensory nerve and the intervertebral disc has been previously considered to be the sensory nerve mediating the conduction of pain associated with the intervertebral disc, causing low back pain

Key words: chondroitin sulfate, chondroitin sulfate synthase 1, intervertebral disc degeneration, nucleus pulposus, sensory nerve

The sensory nerve can sense a variety of external environmental stimuli and participate in a variety of sensory conduction

Chen Huajiang's team and collaborators from the Department of Orthopedics, Long March Hospital, Affiliated to the Naval Military Medical University, observed that under the condition of sensory nerve loss, the rate of intervertebral disc dehydration accelerated and the progress

This study is the first to elucidate a new mechanism by which sensory nerves communicate with intervertebral disc nucleus cells and participate in regulating intervertebral disc homeostasis, demonstrating that sensory nerves can regulate intervertebral disc homeostasis by secreting neuropeptide CGRP mediated CHSY1 expression in nucleus pulposus cells, and found that Forskolin's therapeutic effect on intervertebral disc degeneration suggests that it can be used as one

The work was published in the journal Advanced Science on September 1, 2022 under the title "Sensory nerve maintains intervertebral disc extracellular matrix homeostasis via CGRP/CHSY1 axis

WILEY

Thesis Information:

Sensory nerve maintains intervertebral disc extracellular matrix homeostasis via CGRP/CHSY1 axis

Bo Hu, Xiao Lv, Leixin Wei, Yunhao Wang, Genjiang Zheng, Chen Yang, Fazhi Zang, Jianxi Wang, Jing Li, Xiaodong Wu, Zhihao Yue, Qiangqiang Xiao, Zengwu Shao, Wen Yuan, Jinsong Li, Peng Cao*, Chen Xu* and Huajiang Chen*

Advanced Science

DOI: 10.

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