Interview with Professor Peng Dantao: The current situation and progress of cognitive impairment in the elderly

With the development of economy and science and technology, the aging phenomenon in China is very serious

The author of this article: Medical Pulse Tong Temple of Heaven Conference Reporting Team

Medical Pulse Tong collated the report, please do not reprint

• Director of the Department of Neurology at Sino-Japanese Hospital and Executive Director of the Geriatrics Center

• Chief Physician, Professor, Doctoral Supervisor

• Member of the Standing Committee of the Geriatrics Branch of the Chinese Medical Association, a member of the Neurology Branch, and the leader of the Geriatric Neurology Group

• Chairman of the Anti-Aging Research Branch of the Chinese Geriatric Health Care Medical Research Association

• Vice Chairman of the Vascular Cognitive Impairment Branch of the Chinese Stroke Society

• Vice Chairman of the Psychosomatic Medicine Professional Committee of the Chinese Mental Health Association

• Associate Editor of Chinese Journal of Neuroimmunology and Neurological Diseases, Editorial Board Member of Chinese Journal of Neurology and Chinese Journal of Geriatrics

• Presided over 2 major projects of the Ministry of Science and Technology, 1 major project of the Central Insurance Commission, 3 National Natural Science Foundation of China, 1 Capital Development Fund, 1 project of Beijing Municipal Science and Technology Commission, etc

• Won the first prize of pharmaceutical innovation of the Chinese Association of Traditional Chinese Medicine, the first prize of the Science and Technology Progress Award of the Chinese Geriatric Health Care Medical Research Association, etc

• Published 95 articles in SCI and statistical source journals (first/corresponding author), edited 2 monographs, presided over 5 national guidelines, and presided over 3 national multi-center drug clinical studies

Medical Pulse:

The problem of population aging in China has become more and more serious, and the problem of elderly diseases that follow is more prominent, please talk about the current situation of cognitive impairment in the elderly in China?

Peng Dantao

professor

Cognitive impairment in the elderly can be divided into mild cognitive impairment and AD according to severity, and some studies have found that blood biomarkers contribute to the early diagnosis of AD, can you please talk about this?

Peng Dantao

professor

At present, our team is conducting an international clinical drug trial study of the AD vaccine, improving the Aβ-PET test for patients free of charge, and more than 200 patients have improved the Aβ-PET test, which has a major role
in the early diagnosis and further diagnosis of Alzheimer's disease.

In addition, the international diagnosis of AD peripheral blood biomarker (biomarker), such as Aβ42/40 or abnormal site phosphorylated tau protein (217, 181, 231, etc.
), will become a very simple and relatively specific method
for screening and diagnosing AD.

Big data research, the risk factors, genes, biological tests, imaging results, scales and other information of patients diagnosed with AD are integrated and analyzed, and a data model is established to log the corresponding information of the patient to be diagnosed into the data model, and through big data analysis, the risk of AD in the patient to be diagnosed is determined, and the population that may be affected by AD is screened out, so as to help identify AD
early.

Peng Dantao

professor

The main thing about early recognition is that it is recognized in the patient's near-normal situation
.

Mainly around the pathogenesis of the disease pathology to detect, such as age spots PET, tau-PET or peripheral blood Aβ or tau, scales, functional magnetic resonance and big data analysis results, our team is also doing AD susceptible gene screening kit
.

It is hoped that patients with AD will be identified early through multiple means, followed by a series of pharmacological and non-pharmacological treatments for intervention
.

Non-pharmacological means include the prevention
of risk factors.

There are more than a dozen risk factors that may be associated with AD in international reports: blood pressure, blood sugar, lipid problems; Physical and mental problems of old age depression, such as depression, anxiety, insomnia; Bad habits, such as tobacco and alcohol; Hearing loss, falls, etc
.

All of these risk factors can be managed and controlled
as early as possible.

In addition, a series of vaccines to Aβ or tau can be given early to prevent, strengthen cognitive function exercise, and physical and mental pleasure
.

Delay the occurrence
of AD by means of individualized multi-factor multi-aspect management.

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