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Differential diagnosis of multiple sclerosis Knowledge cards
Time of Update: 2022-09-21
World Multiple Sclerosis Day. Medical pulse communicationGuideIn 2019, Xiaobian launched the "Knowledge Card" column, which sorts out some knowledge points related to clinical diseases in the form of simple and easy-to-save forms for clinicians to use fragmented time to study warmly, which is quite popular with doctor readers!
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Nature Medicine: Stem cell + gene therapy for the treatment of frostbite clinical trial results released, good safety, the future can be expected
Time of Update: 2022-09-21
The research team conducted the first human clinical trial using this combination therapy, and the results showed that the new therapy was safe for patients with frostbite, and that these neural progenitor cells were able to differentiate into astrocytes and express the GDNF protein in the spinal cord for more than 3 years (42 months) in a single treatment.
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Neuron's Ju Huang team at Shanghai Jiao Tong University found that repetitive behaviors of always pulling hair and scratching the skin affect the underlying mechanism of anxiety
Time of Update: 2022-09-21
Taken together, the study reveals the dual role of the CeA-MPLSST-VTA DA circuit in self-grooming and post-stress anxiety regulation, and conceptualizes MPLSST neurons as bridges connecting the stress and reward systems of mice.
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Ibrain fulaxin protects cortical neurons from neonatal hypoxic-ischemic encephalopathy by upregulating vascular endothelial growth factor
Time of Update: 2022-09-21
Neonatal hypoxic-ischemic encephalopathy (NHIE) is a perinatal neonatal brain injury disease caused by hypoxia, manifested by cell damage, metabolic disorders, vascular dysregulation disorders, and decreased cerebral blood flow.
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No wonder it's so hard to lose weight! Nature's new findings: Addicted to sugar and fat, the intestines and brain have to "carry the pot"
Time of Update: 2022-09-21
iNaturePeople who have always lost weight and have not reached their goals may often encounter this scenario - when eating sweet or high-calorie foods, they will always constantly hint to themselves:
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Cell: Scientists are the first to discover that exosomes mediate fat-to-brain communication and promote the development of diabetic cognitive dysfunction
Time of Update: 2022-09-21
In order to further investigate whether adipose tissue-derived EVs are directly involved in the occurrence of diabetic cognitive dysfunction, the researchers treated normal mice with high-fat mice and adipose-derived EVs from diabetic patients by tail vein injection and hippocampal stereotactic injection, respectively, and found that normal mice had significant synaptic loss and cognitive function impairment.
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Express Targeting mitochondria for cancer, Alzheimer's disease and Parkinson's disease! Xinrui completed a $72.5 million Series A financing round
Time of Update: 2022-09-21
On the other hand, Pretzel has also developed small molecule drugs to regulate and control proteins involved in mtDNA replication, transcription and translation, with the potential to treat diseases caused by mitochondrial mutations and abnormalities related to metabolism, cancer, and neurodegeneration.
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Cell Metabolism's team at Nanjing University reveals a new mechanism for fat-brain communication to affect diabetic cognitive dysfunction
Time of Update: 2022-09-21
In addition, studies have shown that targeting adipose tissue-derived EVs or their cargo miRNAs can significantly prevent obesity-associated insulin resistance cognitive impairment, a finding that may provide promising strategies for drug interventions for diabetic cognitive impairment.
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A single genomic alteration increases neural formation in modern humans| Science selected week
Time of Update: 2022-09-21
" "Welcome to follow the official public account of ScienceClick "Read the original article" below to access the original English textLight up your thumbs up for this issue of ScienceClick on the blue word above to follow usResearchers have reported that a single amino acid change in the transketone-like 1 (TKTL1) protein may give modern humans a greater advantage than ancient contemporaries such as Neanderthals by increasing neocortical neurogenesis.
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Alzheimer's disease may usher in a landmark treatment! In-depth interpretation of the important results of AAIC 2022, Subcutaneous injection therapy for Alzheimer's disease is expected to slow down the depth of cognitive decline singularity
Time of Update: 2022-09-21
Professor Wang Yanjiang, director of the Department of Neurology at Daping Hospital of the Army Military Medical University, told Singularity Network, "This study gives us a new understanding of the cognitive improvement effect of high-dose Gantenerumab treatment.
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The FDA lifted the clinical hold and a variety of innovative therapies for DMD are on the market
Time of Update: 2022-09-21
September 9, 2022 /eMedClub News/-Sarepta Therapeutics, a biology company dedicated to the development of precision therapies for rare diseases, announced that the FDA has lifted the Phase 2 clinical
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Sino-Korean Stroke Lipids Expert Forum
Time of Update: 2022-09-21
PCSK9i iloizumab significantly reduces LDL-C levels, stabilizes or reverses plaque, and significantly improves the clinical outcomes of stroke patients, and has a good safety profile, without increasing the risk of adverse events such as cognitive dysfunction and cerebral hemorrhage, so it has been recommended by many authoritative guidelines at home and abroad.
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Nature sub-journal: Neurons on the same day are more likely to "advance and retreat"
Time of Update: 2022-09-21
Recently, in a new study published in Nature Neuroscience, a team of researchers from the Grossman School of Medicine at New York University found that whether awake or asleep, neurons with the same "birthday" showed unique synergistic activity in different brain states throughout the adulthood of mice compared to hippocampal neurons that were "born" on different days.
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Science: A change in just one amino acid that makes the human brain better than Neanderthals?
Time of Update: 2022-09-21
Thesis link: open reprint welcome to forward to the circle of friends and WeChat group Written by Wang Cong Editor Wang Duoyu Typography Water Chengwen Homo neanderthalensis, is an ancient human that was active in Europe 200,000 years ago, and they began to rule the whole of Europe, west Asia and northern Africa from 120,000 years ago, but surprisingly, About 35,000 years ago, neanderthals began to shrink rapidly, eventually becoming completely extinct about 30,000 years ago.
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Neuron: Ju Huang's team reveals neural circuit mechanisms that regulate emotions through stereotyped repetitive behavior Cell Press talks to scientists
Time of Update: 2022-09-21
Life SciencesLife scienceOn September 6, 2022, The Huang Ju team of Shanghai Jiao Tong University School of Medicine published the research results entitled "Excitatory SST neurons in the medial paral
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J Neuroinflammation Review— COVID-19 and Cognitive Impairment: Neuroinvasiveness and Blood-Brain Barrier Dysfunction
Time of Update: 2022-09-21
Thus, once SARS-CoV-2 is inhaled into the nasal cavity, the virus may spread into the CNS through receptors ACE2 and TMPRSS2 on the olfactory mucosa along the retrograde axons of the olfactory nerve, leading to neuronal necrosis and dysfunction, which leads to damage to the central nervous system leading to cognitive impairment (Figure 1).
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Listen to the whole process of good sen how to manage Parkinson's disease patients throughout the process? Listen to the experts of West China Hospital!
Time of Update: 2022-09-21
Professor Shang Huifang pointed out, "The one-stop diagnosis and treatment center includes both disease education and clinical medical management, with experts in rehabilitation medicine, imaging medicine, psychology and psychiatry, nutrition and nursing, etc.
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Whether thrombolysis should be done before stroke thrombolysis
Time of Update: 2022-09-21
This article is from the NEJM Journal WatchShould Bridging Thrombolysis Be Used Before Thrombectomy for Stroke?Whether thrombolysis should be done before stroke thrombolysisReviewed by Seemant Chaturvedi, MDYes. Current guidelines recommend intravenous thrombolysis (IVT) for specific acute ischemic stroke patients, and also recommend that endovascular embolism (EVT) be considered in patients with anterior circulating macrovascular occlusion.
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Chart Summary Exploring the "Illusion of Vision"
Time of Update: 2022-09-21
e. complex visual hallucinations, in which the patient sees a fully formed person, a furry animal, or an inanimate object, usually occurring when the environment is under-illuminated (such as at night), the image may be normal size or miniaturized, black and white, or colored, and may be incomplete.
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The brain is cut into pieces and regenerated, and scientists finally see how it does it
Time of Update: 2022-09-21
So, is it the neural stem cells of the reaEGC subtype that help the salamander regenerate neurons?To confirm this hypothesis, the scientists looked more closely at the salamander terminal brain 15 days after the injury.
