Cell: Scientists are the first to discover that exosomes mediate fat-to-brain communication and promote the development of diabetic cognitive dysfunction

Diabetes significantly increases the risk of cognitive impairment (including mild cognitive impairment and dementia), seriously threatening healthy survival in

Abnormal adipose tissue function plays an important role

In addition to soluble adipokines, recent studies have found that adipose tissue can also secrete extracellular vesicles (EVs) as novel aliphatic factors that play an important role in inter-organ communication, such as liver and skeletal muscle, and are involved in the development of

On September 6, 2022, the team of Professor Bi Yan of the Department of Endocrinology of Gulou Hospital Affiliated to Nanjing University School of Medicine, together with Professor Zhang Chenyu and Associate Professor Li Liang of the School of Life Sciences of Nanjing University, published a paper entitled :Extracellular vesicles mediate the communication of adipose tissue with brain and promote The research paper on cognitive impairment associated with insulin resistance has found for the first time that exosomes mediate fat-brain-to-brain communication and promote the occurrence

The research team first used fat grafting to study the role of

In order to further investigate whether adipose tissue-derived EVs are directly involved in the occurrence of diabetic cognitive dysfunction, the researchers treated normal mice with high-fat mice and adipose-derived EVs from diabetic patients by tail vein injection and hippocampal stereotactic injection, respectively, and found that normal mice had significant synaptic loss and cognitive function impairment

Previous studies have shown that miRNAs are key molecules

Finally, they studied the relationship