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Alveolar macrophages help CD8+ T cells protect against viral infections
Time of Update: 2023-02-03
+Given that the lung is the main tissue of IAV and SARS-CoV-2 infection, the discovery of the expansion mechanism of memory CD8+ cells in the lung is expected to lead to the development of new vaccines to induce cellular immunity.
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Feng Wei's research group and Xu Tao's group collaborated to reveal the regulation of membrane fusion related Mint1-Munc18-1-syntaxin...
Time of Update: 2023-02-03
Membrane fusion during vesicle transport is a key biological process in eukaryotic cell life activities, finely regulated by a variety of proteins and their complexes. The SNARE complex is the core p
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Targeted inhibition of excessive inflammatory response
Time of Update: 2023-02-03
Not long ago, the journal Nature announced the top ten people with scientific impact in 2022, and Cao Yunlong, associate researcher of Peking University's Biomedical Frontier Innovation Center (BIOPI
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Nature discovered a new CRISPR gene scissors in two articles in the same period
Time of Update: 2023-02-03
This defense is based on a common mechanism: CRISPR ribonucleic acid (crRNA), which acts as "guide RNA," helps detect regions of the foreign genome, such as the DNA of viruses, for targeted cleavage.
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New insights into the fundamental processes of mitochondria
Time of Update: 2023-02-03
Human mitochondria require mtRF1 for translation termination at non-canonical stop codons Researchers at Karolinska Institute discovered the function of the release factor mtRF1 in the final step of mitochondrial protein synthesis.
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Yang Yue's team at Tsinghua University evaluated the price, efficacy and safety of similar onco-targeted drugs produced and imported
Time of Update: 2023-02-03
Figure 1: China's drug approval and review reform and the development process of national medical insurance negotiationIn order to solve the above problems, Asia has systematically evaluated the price (initial launch and latest monthly treatment cost), efficacy and safety of similar anti-tumor targeted drugs produced and imported in China.
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Brain tissue discovers new genes associated with multiple sclerosis
Time of Update: 2023-02-03
In the study, the researchers found that the SHMT1, FAM120B, and ICA1L genes (and their proteins) were expressed at different levels in the brain tissue of people with multiple sclerosis than in the control group.
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Humans are still evolving! The power comes from microgenes in the genome
Time of Update: 2023-02-03
Saghatelian explains that although they possess start and stop codons that can be read by a cell's transcriptional machinery like traditional genes, these so-called microgenes — sometimes called short open reading frameworks (sORFs) — have long been considered functionless.
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SCI ADV: Heavy! Scientists identify key neurons that maintain normal body temperature in mammalian organisms
Time of Update: 2023-02-03
Researchers don't know exactly what the bidirectional controller of the thermoregulatory center in the preoptic area (POA) looks like 。 Recently, a study entitled "Prostaglandin EP3 receptor-expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling" published in the international journal Science Advances.
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Progress in epoxyhydrolase calculations, design, and synthesis of chiral heterocyclic compounds
Time of Update: 2023-02-03
Schematic diagram of computational design epoxy hydrolase to achieve synthesis of chiral heterocyclic compounds Chiral heterocyclic compounds are widely used in synthetic chemistry, natural products, pharmaceuticals, pesticides and materials, among which chiral nitrogen/oxygen heterocyclic compounds are the core building blocks of many biological and physiologically active molecules.
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Nature sub-journal: Genetically modify mitochondria to charge them with sunlight, thereby extending lifespan
Time of Update: 2023-02-03
Mitochondrial dysfunction is a consequence of aging, and the study found that simply harnessing light-energy mitochondria to boost metabolism could allow Caenorhabditis elegans to live longer, healthier lives.
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CRISPR+Covid=? Nature has discovered for the first time that the CRISPR protein can act as a multipurpose self-destruct system for bacteria
Time of Update: 2023-02-03
RNA targeting unleashes indiscriminate nuclease activity of CRISPR-Cas12a2 In this illustration based on cryo-electron microscopy images, the Cas12a2 protein unlocks the DNA double helix, allowing it to cut DNA single strands (blue and green).
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Paxlovid is effective in reducing COVID-19 hospitalizations in vaccinated adults aged 50 years and older
Time of Update: 2023-02-03
The antiviral drug nirmatrelvir + ritonavir (Paxlovid) received emergency use authorization in December 2021 for the treatment of COVID-19. In clinical trials, this antiviral drug was associated with
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【Scientific Research Dynamics】Important progress in the research of Zhao Yanbing/Yang Xiangliang's research group: the radiofrequency field of bivalent gold nanoclusters activates tumor cell pyrozosis...
Time of Update: 2023-02-03
On December 29, ACS Nano, a journal of the American Chemical Society, published online the research paper "Radiofrequency-Activated Pyroptosis of Bi-Valent Gold" by Professor Zhao Yanbing and Professor Yang Xiangliang, School of Life Science and Technology, Huazhong University of Science and Technology, National Engineering Research Center for Nanomedicine Nanocluster for Cancer Immunotherapy”。 Cancer immunotherapy shows great potential in killing tumor cells.
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Physical Review X published the research of Li Yuan, Peng Yingying's research group and collaborators on the candidate material of Kitaev model, sodium, cobalt, antimony and oxygen
Time of Update: 2023-02-03
Recently, the research group of Associate Professor Li Yuanchangping of the Center for Quantum Materials Science, School of Physics, Peking University, successfully grew large-size, high-quality Na3Co2SbO6 single crystals.
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A new generation of "breakthrough" diet pills
Time of Update: 2023-02-03
It appears to have the opposite effect on type 2 diabetes — GLP-1 boosts insulin secretion and lowers blood sugar — making it an attractive treatment for obesity, says Jens Juul Holst, a medical physiologist at the University of Copenhagen who discovered and described GLP-1.
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Progress has been made in the field of self-healing ionic skin
Time of Update: 2023-02-03
According to the mechanical stimulus response principle of tactile cells, the research team designed and synthesized a new thermoplastic polyurethane material containing dynamic disulfide bond functional groups and chlorine substituents by simulating the self-healing function and bioion signaling mechanism of real human skin.
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Eating tomatoes improves the gut microbiome, at least pigs can
Time of Update: 2023-02-03
Based on these findings from short-term interventions, the research team plans to conduct similar studies in humans to explore potential health-related links between tomato consumption and changes in the human gut microbiota.
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Two articles capture the new connection between the intestines and the brain
Time of Update: 2023-02-03
New University of Oregon research on zebrafish suggests that gut microbes prompt specific cells to prune additional connections in brain circuits that control social behavior.
New University of Oregon research on zebrafish suggests that gut microbes prompt specific cells to prune additional connections in brain circuits that control social behavior.
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30% increased risk of dementia with shift work
Time of Update: 2023-02-03
The study showed a 30% increased risk of all-cause dementia in shift work compared to non-shift work, and that this relationship was not altered by genetic predisposition.
