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Nature discovered a new CRISPR gene scissors in two articles in the same period
Time of Update: 2023-02-03
This defense is based on a common mechanism: CRISPR ribonucleic acid (crRNA), which acts as "guide RNA," helps detect regions of the foreign genome, such as the DNA of viruses, for targeted cleavage.
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Nat Aging: Increasing levels of lamin C is expected to slow cardiac aging
Time of Update: 2023-02-03
Dr. Natalie Kirkland, the first author of the paper and a postdoctoral scholar in Engler's lab, used fruit flies to conduct experiments and found that lamin C (LamC), a protein responsible for maintaining the structural integrity of the nucleus of heart cells, declines with the aging of fruit flies.
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Science Advances: The early stages of sex determination in mice and humans
Time of Update: 2023-02-03
A study published by researchers at Bar-Ilan University provides a solution to this challenge by developing new tools to create somatic/supporting cells of gonads that would be able to mimic stem cells from DSD individuals in a dish.
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The research results of Zhai Qiwei's research group of the Institute of Nutrition and Health were specially evaluated by Nature Research Highlights
Time of Update: 2023-02-03
On December 13, the international academic journal Nature published a report titled "Why does fat return after dieting?" The microbiome might have a hand", recently published in Nature Metabolism by Zhai Qiwei's research group The research results on the mechanism of body fat rebound after dieting (https://doi.
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Chinese scientists have found that intermittent fasting based on traditional Chinese medicine nutrition therapy has made nearly half of patients with type 2 diabetes say goodbye to hypoglycemic drugs
Time of Update: 2023-02-03
Recently, Liu Dongbo's team from Hunan Agricultural University and Hu Minghai's team from Central South University published the results of a clinical study in the well-known endocrinology journal "Journal of Clinical Endocrinology and Metabolism" [5], showing that compared with the control group, receiving 3 months of traditional Chinese medicine nutrition therapy (CMNT), that is, intermittent fasting with a special diet, can make more T2D patients meet the criteria for diabetes remission (glycated hemoglobin A1c [HbA1c] is less than 6.
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Hepatology: Xu Xiao's team at Zhejiang University revealed the key mechanism of liver cancer immunotherapy failure
Time of Update: 2023-02-03
Tumor cells with high expression of sulfotransferase 2B1 (SULT2B1) will release cholesterol sulfate, inhibit DOCK2 enzyme activity, destroy the mitochondrial homeostasis of effector T cells, promote the depletion of the function of effector T cells, allow tumor cells to gain resistance to immunotherapy, and accelerate the progression of liver cancer.
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New progress has been made in the soluble carbon transport mechanism driven by multi-interface hydrological processes in key karst slope zones
Time of Update: 2023-02-03
Under the action of karst, the dual-dimensional structure of aboveground and underground in the karst area developed, and the hydrological process was mainly the underground process. The core zone of
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Chen Zhixing's research group in the Institute of Future Technology developed a new probe to realize mitochondrial multicolor STED imaging
Time of Update: 2023-02-03
published a research paper entitled "Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain" and was selected as the cover article 。 The study reported a mitochondrial crest dye PK Mito Orange (PKMO) suitable for STED nanomicroscopy with excellent photostability and significantly reduced phototoxicity, enabling long-term, super-resolution mitochondrial dynamic imaging in immortalized mammalian cell lines, primary cells, and tissues, 3D-STED imaging of individual mitochondria, and multicolor STED imaging (Figure 1).
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New insights into the fundamental processes of mitochondria
Time of Update: 2023-02-03
Human mitochondria require mtRF1 for translation termination at non-canonical stop codons Researchers at Karolinska Institute discovered the function of the release factor mtRF1 in the final step of mitochondrial protein synthesis.
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Humans are still evolving! The power comes from microgenes in the genome
Time of Update: 2023-02-03
Saghatelian explains that although they possess start and stop codons that can be read by a cell's transcriptional machinery like traditional genes, these so-called microgenes — sometimes called short open reading frameworks (sORFs) — have long been considered functionless.
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This preprint article was finally published in Nature
Time of Update: 2023-02-03
Analysis of autopsy tissue samples from 44 people who died from COVID-19 showed that the SARS-CoV-2 virus spread throughout the body, including into the brain, and lingered for nearly 8 months.
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Challenging past theories: Scientists have discovered a homolog of a well-known human protein in nematodes
Time of Update: 2023-02-03
Caenorhabditis elegansIn a recent study published in Nature Communications, Dr. Emily Spaulding and Dr. Dustin Updike discovered a homologue of a well-known human protein nucleolar protein in Caenorhabditis elegans, a small transparent worm.
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Self-assembling proteins can store cellular "memories"
Time of Update: 2023-02-03
”The researchers are also working on engineering the system by increasing the number of different subunits that can be merged so that they can be combined in the same placeessayRecording of cellular physiological histories along optically readable self-assembling protein chains As cells perform their daily functions, they turn on a variety of genes and cellular pathways.
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Personalized tracking of M proteins, EasyM advances precision medicine practices in myeloma
Time of Update: 2023-02-03
Serum protein electrophoresis (SPEP) and immunofixation electrophoresis (IFE) techniques[3]In view of the problems existing in the rapid and accurate clinical detection of M protein, Shanghai Fast Sequence Bio published a report on "Based on Mass Spectrometry Technology.
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SCI ADV: Heavy! Scientists identify key neurons that maintain normal body temperature in mammalian organisms
Time of Update: 2023-02-03
Researchers don't know exactly what the bidirectional controller of the thermoregulatory center in the preoptic area (POA) looks like 。 Recently, a study entitled "Prostaglandin EP3 receptor-expressing preoptic neurons bidirectionally control body temperature via tonic GABAergic signaling" published in the international journal Science Advances.
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Scientists discover that Confucius reveals the early evolutionary mechanism of birds
Time of Update: 2023-02-03
Because the specimen of Confucius is in a special ontogenetic state, it provides the first convincing evidence for the understanding of the earliest "tail bone" vertebral composition of birds.
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The team of Ye Jian of Shanghai Jiaotong University achieved the detection of Raman optical signal penetrating 14 cm muscle tissue within the safe dose of light
Time of Update: 2023-02-03
Non-invasive detection of tumor lesions in vivo is essential for clinical oncology diagnosis and treatment. Medical imaging techniques such as computed tomography, magnetic resonance or positron emis
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The Lancet Oncology: New bispecific antibodies are expected to become a weapon against various HER2-positive solid tumors!
Time of Update: 2023-02-03
Targeted therapy for HER2 is one of the most successful targeted therapies at present, and the iconic monoclonal antibody-based targeted drug trastuzumab has been widely used in the treatment of gast
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BMJ: These healthy lifestyles can extend life expectancy by 5 years and prevent Alzheimer's disease
Time of Update: 2023-02-03
);Maintain cognitive activities such as reading and puzzles;exercise for at least 150 minutes per week;Non-smoking;Limit alcohol consumption (no more than 15 grams of alcohol per day for women and 30 grams per day for men);Klodian Dhana, lead author of the study and an assistant professor at the Rush Institute for Healthy Aging at Rush University Medical Center, said the study comprehensively assessed these lifestyles as they may have a synergistic effect on dementia risk.
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Construction of ionizable iron nanoadjuvants for personalized tumor vaccine treatment
Time of Update: 2023-02-03
202209910(Contributed by: Yu Navy Research Group) Tumor vaccines represent a therapeutic method that can induce body-specific and persistent anti-tumor immune response, and have great prospects for improving clinical tumor treatment.
