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Scientists have identified three genes and their expression proteins
that may be involved in the pathogenesis of multiple sclerosis.
In the study, the researchers found that the SHMT1, FAM120B, and ICA1L genes (and their proteins) were expressed at different
levels in the brain tissue of people with multiple sclerosis than in the control group.
A new study published Dec.
7 in the Annals of Clinical and Translational Neurology identifies three genes and their expression proteins
that may be involved in the pathogenesis of multiple sclerosis.
By comparing information on genes and proteins expressed in the brains of thousands of multiple sclerosis patients and non-multiple sclerosis patients, the researchers found that the expression levels of the SHMT1, FAM120B, and ICA1L genes (and their proteins) differed
in the brain tissues of patients and controls.
Studying the function of these genes may reveal new information
about the mechanisms by which multiple sclerosis develops and progresses.
"Our findings shed new light on the pathogenesis of multiple sclerosis and set promising targets
for future therapeutic research," the authors wrote.
References:
“Brain proteome-wide association study linking-genes in multiple sclerosis pathogenesis” by Tingting Jia, Yanni Ma, Fengqin Qin, Feng Han and Chengcheng Zhang, 7 December 2022, Annals of Clinical and Translational Neurology.
