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Technology! Chinese scholars bring new expansion microscopy techniques
Time of Update: 2023-02-03
"We overcame some of the long-term challenges of expansion microscopy," says Yongxin Zhao, "and one of Magnify's main selling points is the general strategy of preserving tissue biomolecules, including proteins, nuclear fragments, and carbohydrates, within the expanded sample.
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The He Hang-Deng Xingwang team successfully constructed the T2T genome maps of two kiwifruit species
Time of Update: 2023-02-03
Under the condition that China's arable land area is limited, greatly improving crop yield and quality is an inevitable way to meet agricultural security and develop agricultural economy. With the ap
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Proof-of-concept and drug candidate discovery of CHK1/FLT3 dual-targeted inhibitors
Time of Update: 2023-02-03
Based on the synergistic potential of CHK1 inhibitors and FLT3 inhibitors in combination with FLT3 inhibitors, this study proposed the concept of innovative drug development with dual targeted inhibition of CHK1/FLT3, and identified TLX83, a preclinical candidate molecule for dual targeted inhibition of FLT3/CHK1, which can not only strongly inhibit the growth of a variety of FLT3-acquired mutant cells, but also fight cytokine-induced adaptive resistance.
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Hoarding medicine is not as good as hoarding "good body": New Year's exercise goals can be set a little lower, just a few minutes a day
Time of Update: 2023-02-03
New research shows that even muscle contractions once a day, 5 days a week, can improve muscle strength if you stick to it for a month.
New research shows that even muscle contractions once a day, 5 days a week, can improve muscle strength if you stick to it for a month.
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New bacterial therapies for lung cancer
Time of Update: 2023-02-03
Researchers at Columbia University's School of Engineering report that they have developed a preclinical evaluation pipeline for the characterization of bacterial therapies in lung cancer models.
Researchers at Columbia University's School of Engineering report that they have developed a preclinical evaluation pipeline for the characterization of bacterial therapies in lung cancer models.
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Zhong Qing/Wang Weiwei, School of Basic Medical Sciences, et al. reported a new spray-type contrast agent that rapidly identifies tumor boundaries
Time of Update: 2023-02-03
During surgery, S-4-NP can be directly sprayed with the isolated tumor tissue section, and the tumor tissue can be clearly identified within 3 minutes through near-infrared imaging, thereby helping clinical surgeons quickly distinguish the boundary between tumor tissue and normal tissue, and judge the surgical margin (see Figure 3 for the complete imaging video).
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Wang Zhao's team at Tsinghua University revealed that a high-fat diet rescued the premature aging-related phenotype of SIRT6 knockout mice by improving the intestinal flora
Time of Update: 2023-02-03
Recently, Professor Wang Zhao's research group of Tsinghua University School of Pharmacy published a research paper in the journal Aging Cell entitled: Decreased Enterobacteriaceae translocation due
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Proc. Natl. Acad. Sci. U.S.A.: Development of new probe for mitochondrial multicolor STED imaging
Time of Update: 2023-02-03
published a research paper entitled "Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain" and was selected as the cover article 。 The study reported a mitochondrial crest dye PK Mito Orange (PKMO) suitable for STED nanomicroscopy with excellent photostability and significantly reduced phototoxicity, enabling long-term, super-resolution mitochondrial dynamic imaging in immortalized mammalian cell lines, primary cells, and tissues, 3D-STED imaging of individual mitochondria, and multicolor STED imaging (Figure 1).
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Nature: The new crown can change the immune system, or cause an excessive immune response
Time of Update: 2023-02-03
The study showed that after infection with the new crown, even mild symptoms can change the immune status of men, making men respond more strongly to the flu vaccine, indicating that after infection, when faced with other viruses, men trigger a stronger inflammatory response, leading to more pronounced functional changes in the male immune system, even long after recovery.
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New peptides with potential beyond existing anti-cancer drugs
Time of Update: 2023-02-03
The cyclic peptides recently discovered by the researchers have the ability to specifically bind to ubiquitin protein chains, which are often used as "death tags" for damaged proteins.
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Nature Genetics international large-scale research has revealed dozens of new genes linked to heart disease
Time of Update: 2023-02-03
Most of the new genomic loci were associated with very small changes in CAD risk, suggesting that few, if any, common genetic variants that had a significant impact on CAD risk by studying people of predominantly European ancestry were yet to be discovered, and to improve their discovery power, the researchers combined their large dataset with data from tens of thousands of individuals of East Asian descent from the Japan Biobank, including 29,000 CAD patients.
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Nature solves decades of puzzle: the original p53 was destroyed in a completely new way
Time of Update: 2023-02-03
Article BRD8 maintains glioblastoma by epigenetic reprogramming of the P53 network Image: Mills Lab weathered rain erosion during the Darlene Capone Brain Tumor Foundation's second annual walk to support glioblastoma research.
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Chinese scholars have made progress in the research of addiction memory mechanism
Time of Update: 2023-02-03
Figure Addiction cues regulate the dynamic reshaping mechanism of synaptic memory in addiction With the support of the National Natural Science Foundation of China (grant number: 81822017, 82101565), the team of Professor Yuan Yifei of the Shanghai Mental Health Center (National Center for Mental Illness) made progress in the study of the mechanism of addictive memory, and the research results were based on "Retrieval-extinction of drug memory requires AMPA receptor.
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Immunity: The complexity of TRM cell biology in the gut
Time of Update: 2023-02-03
The researchers observed that TRM cells of each tissue type exhibited different cytokine and granzyme expression patterns, as well as substantial transcriptional, epigenetic, and functional heterogeneity.
The researchers observed that TRM cells of each tissue type exhibited different cytokine and granzyme expression patterns, as well as substantial transcriptional, epigenetic, and functional heterogeneity.
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Alzheimer's disease: a gene associated with immune cells in the brain
Time of Update: 2023-02-03
Researchers at Indiana University School of Medicine are studying how to reduce a genetic variant found in brain immune cells that reduces the risk of late-onset Alzheimer's disease.
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The main pathogen taxa of fungal meningitis are endemic to the regulatory basis and evolutionary pathways of the main pathogen taxa
Time of Update: 2023-02-03
On December 24, 2022, the research team of Wang Linqi, State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, published an article entitled "Regulatory basis for reproductive flexibility in a meningitis-causing fungal pathogen" in Nature Communications.
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Chinese scholars have made progress in the latitude of the lunar surface and the formation of solar wind water
Time of Update: 2023-02-03
Fig. 1 Hydrogen content depth profile of Chang'e-5 lunar soil particles and their space regolith layer thickness Fig. 2 Numerical simulation of hydrogen content depth profile in silicate glass and mi
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eLife: How humans lose body hair
Time of Update: 2023-02-03
Image: An unprecedented study comparing the genomes of 62 mammalian species answers a question about the fundamental mechanism that forms human characteristics: scarcity of body hair.
Image: An unprecedented study comparing the genomes of 62 mammalian species answers a question about the fundamental mechanism that forms human characteristics: scarcity of body hair.
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Nature: After contracting the new coronavirus, has the body's response to other threats changed? It depends on the gender
Time of Update: 2023-02-03
In the study, a team led by Tsang, who at the time at the National Institute of Allergy and Infectious Diseases (NIAID), and his colleagues, including lead author Rachel Sparks, also from NIAID, systematically analyzed the immune response in healthy people who received the flu vaccine.
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Nature Biotechnology: Prevents rejection of transplanted cells by tricking antibodies
Time of Update: 2023-02-03
A new approach could overcome the persistent barriers of cell transplantation and immunotherapyResearchers at the University of California, San Francisco, have developed a novel, potentially life-saving way to prevent antibodies from triggering immune rejection in engineered therapy cells and transplanted cells.
