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To infect the brain, the fungus learns to make itself smaller in guano!
Time of Update: 2023-02-03
Figure 3 Macrophage recognition of mannose helps small ex vivo cells to be uptaken by organs (Source: [1])03 One side of soil and water culture and one side of "bacteria": the pigeon fecal environment enhances the organ entry ability of Cryptococcus neoformansThe results of the venous transmission model showed that cell size was not the only factor affecting the rate of diffusion, and that the culture conditions of the fungus also greatly influenced the distribution in the organ.
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Use the sword of biological network big data to solve the mystery of corn genetics
Time of Update: 2023-02-03
Inheritance and innovation kicked off the era of maize multi-dimensional network map On December 30, 2022, the journal Nature and Genetics published the collaborative research paper "A multi-omics in
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Eye tracking in visual challenges reveals neural coding
Time of Update: 2023-02-03
Instead, human vision is an active process that includes interactions between external objects and eye movements," Ahissar said.
Instead, human vision is an active process that includes interactions between external objects and eye movements," Ahissar said.
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iScience: Genome sequencing of endangered sharks
Time of Update: 2023-02-03
Image: Scientists have sequenced the genomes of hammerhead sharks and shortfin mako sharks at the chromosomal level, showing that their populations declined more than 250,000 years ago.
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Nature: The key to the transformation of chronic blood cancers into aggressive diseases
Time of Update: 2023-02-03
The researchers also tested a drug compound that inhibits DUSP6 and found that this compound (used only in animal studies) prevented the progression of chronic disease to aggressive disease in two different mouse models of cancer and in mice with human tumors sampled from patients.
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The regulation of bile acid metabolism in piglets with intrauterine growth retardation has progressed in stages
Time of Update: 2023-02-03
Paper links: 1 2 3 4 5 6 7 Feeding effect of bile acids added to feed on normal pigs and IUGR piglets Intrauterine growth retardation (IUGR) is a general term for fetal growth and development disorders in the mother's womb, IUGR animals are manifested as growth retardation, abnormal development, disease resistance and decreased meat quality, early morbidity and mortality are high.
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Zhong Qing/Wang Weiwei, School of Basic Medical Sciences, et al. reported a new spray-type contrast agent that rapidly identifies tumor boundaries
Time of Update: 2023-02-03
During surgery, S-4-NP can be directly sprayed with the isolated tumor tissue section, and the tumor tissue can be clearly identified within 3 minutes through near-infrared imaging, thereby helping clinical surgeons quickly distinguish the boundary between tumor tissue and normal tissue, and judge the surgical margin (see Figure 3 for the complete imaging video).
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Proof-of-concept and drug candidate discovery of CHK1/FLT3 dual-targeted inhibitors
Time of Update: 2023-02-03
Based on the synergistic potential of CHK1 inhibitors and FLT3 inhibitors in combination with FLT3 inhibitors, this study proposed the concept of innovative drug development with dual targeted inhibition of CHK1/FLT3, and identified TLX83, a preclinical candidate molecule for dual targeted inhibition of FLT3/CHK1, which can not only strongly inhibit the growth of a variety of FLT3-acquired mutant cells, but also fight cytokine-induced adaptive resistance.
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New progress has been made in the research of economic plant exchange on the terrestrial Silk Road at the Kunming Plant Institute
Time of Update: 2023-02-03
Recently, based on archaeology, genetics and genomic evidence, the Kunming Institute of Botany, Chinese Academy of Sciences, integrated the transmission routes of 207 crops on the terrestrial Silk Road, focusing on the analysis of 19 crops with genomic evidence (barley, mustard greens, lettuce, buckwheat, chickpeas, barley, wheat, dates, pistachios, vines, alfalfa, walnuts, broccoli, grapes, spinach, apples, cucumbers, mulberry, peas).
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Nature Immunology: Cytokines secreted by T cells
Time of Update: 2023-02-03
Human Th17 cells engage gasdermin E pores to release IL-1α upon NLRP3 inflammasome activation "We don't know how IL-1α is made in T cells and how it is released from the cell," said first author Chao Ying-Yin. The research was part of her doctoral dissertation, and she now works at an international biotech company in Munich, Germany, developing T-cell therapies.
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Nature Subissue: The secret language of decoding photosynthesis
Time of Update: 2023-02-03
Previously, Chen's team demonstrated that certain proteins in the nucleus of plants are activated by light, initiating photosynthesis.
Previously, Chen's team demonstrated that certain proteins in the nucleus of plants are activated by light, initiating photosynthesis.
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AD: Middle-aged fat, thin in old age, dementia risk soared 288%!
Time of Update: 2023-02-03
From the results of the Cox regression model (Figure 2), it is not difficult to find that there is no significant statistical association between people with early BMI decline and late BMI decline and the occurrence of dementia.
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"Nature": Fudan Yuan Peng and others discovered a new mechanism of cognitive decline in Alzheimer's disease patients!
Time of Update: 2023-02-03
The researchers analyzed human brain autopsy samples and found that in the brains of patients with moderate to severe AD, the average number of PAAS near each amyloid plaque was higher and larger, suggesting that the number and size of PAAS may be important factors affecting neural circuit connections and cognitive function in AD patients.
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Science: Chinese scientists led the way in revealing that the ketogenic diet is expected to become a potentially life-saving therapy for cancer patients to combat low platelets
Time of Update: 2023-02-03
In a new preliminary study, researchers from research institutions such as Fudan University in China and Longyan First Hospital affiliated to Fujian Medical University suggest that a high-fat diet ma
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New bacterial therapies for lung cancer
Time of Update: 2023-02-03
Researchers at Columbia University's School of Engineering report that they have developed a preclinical evaluation pipeline for the characterization of bacterial therapies in lung cancer models.
Researchers at Columbia University's School of Engineering report that they have developed a preclinical evaluation pipeline for the characterization of bacterial therapies in lung cancer models.
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Xanthan gum liquid thickener helps lower blood sugar levels
Time of Update: 2023-02-03
Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome Long-term consumption of xanthan gum liquid thickener.
Xanthan gum-based fluid thickener decreases postprandial blood glucose associated with increase of Glp1 and Glp1r expression in ileum and alteration of gut microbiome
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Trends in Plant Science: A high-throughput screening strategy for non-toxic genes of multi-pile rust fungus and resistance genes of maize to southern rust was proposed
Time of Update: 2023-02-03
High-throughput screening strategies for non-toxic genes and maize disease resistance genes in multi-pile rust bacteria The southern rust of maize caused by the infestation of Puccinia polysora underw is widely epidemic in the world, which seriously threatens the safe production of maize in China and the world, and sustainable control of maize southern rust urgently needs reasonable and effective cultivation and planting of resistant varieties.
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Nature Medicine: During the first wave of Omicron, vaccination helped limit the spread of COVID-19
Time of Update: 2023-02-03
" Studies in California prisons have found that recent vaccinations and boosters have reduced contagiousness, but the risk of infection remains highAccording to researchers at the University of California, San Francisco who analyzed transmission between people living in the same cell, vaccination helped limit the spread of COVID-19 in California prisons during the first wave of Omicron.
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Hoarding medicine is not as good as hoarding "good body": New Year's exercise goals can be set a little lower, just a few minutes a day
Time of Update: 2023-02-03
New research shows that even muscle contractions once a day, 5 days a week, can improve muscle strength if you stick to it for a month.
New research shows that even muscle contractions once a day, 5 days a week, can improve muscle strength if you stick to it for a month.
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JACS Cover Shanghai Institute of Materia Medica's cooperation in the development of a near-infrared secondary small molecule fluorescent probe that can cross the blood-brain barrier
Time of Update: 2023-02-03
On December 13, 2022, Han Xiao's laboratory at Rice University and the team of Cheng Zhen of the Center for Molecular Imaging of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences, published a report entitled "Photostable Small-Molecule NIR-II Fluorescent Scaffolds that Cross the Blood" in the Journal of the American Chemical Society Brain Barrier for Noninvasive Brain Imaging", which was selected as the cover article.
