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A new method to retrieve the full-length sequence from unmapped RNA-seq data
Time of Update: 2021-12-30
The research explores the effective unmapped reads information that is usually ignored in RNA-seq analysis, and combines specific reverse transcription primers and next-generation sequencing to retrieve the full-length sequence, providing a new strategy for identifying unknown RNAs and improving The utilization efficiency of RNA-seq data is improved .
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Professor Dieter A. Wolf's team discovered a new anti-tumor mechanism of mitochondrial inhibitors
Time of Update: 2021-12-30
The small molecule compound can effectively target stem cell-like drug-resistant cells, inhibit the proliferation of triple-negative breast cancer transplantation tumors, reverse tumor hypoxia, and promote tumor immune monitoring .
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The 15 billion contrast agent market welcomes new players again!
Time of Update: 2021-12-30
3 products have been approved this yearSales of terminal contrast agents in public medical institutions in China in recent years (unit: 100 million yuan)Source: Mi Nei. com, China's public medical institutions terminal competition patternA few days ago, the 2021 national medical insurance drug catalog adjustment that has received much attention has come to an end.
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Research to prevent the progression of colorectal cancer reveals the key role of hypothalamic oxytocin neurons
Time of Update: 2021-12-30
▲Using chemical genetics method to activate hypothalamic paraventricular nucleus oxytocin neurons can inhibit the progression of colorectal cancer in mice (picture source: reference [1])Further research on the mechanism showed that the anti-tumor effect of activating Oxt neurons depends on its role in the central nervous system .
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Ma Runlin's research group in the School of Life Sciences has made important progress in the evolution of ruminants
Time of Update: 2021-12-30
Professor Ma Runlin’s research team from the School of Life Sciences, University of Chinese Academy of Sciences has made important progress in the study of the animal’s Major Histocompatibility Comple
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Wang Enduo teamed up to reveal the molecular mechanism of human-derived DNMT2 recognition substrate tRNA
Time of Update: 2021-12-30
TRS_Editor A{font-family:;font-size:12pt;}</> On December 7, the international academic journal Nucleic Acids Research published online the latest research results of Wang Enduo's research group at the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences and Liu Rujuan's group at Shanghai University of Science and Technology "Position 34 of tRNA is a discriminative element for m 5 C38 modification by human DNMT2" reveals the molecular mechanism by which human DNMT2 recognizes the substrate tRNA .
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The Dai Jianwu group was invited to publish a review of the frontiers of spinal cord injury regeneration and repair in the top international journal Advanced Functional Materials
Time of Update: 2021-12-30
The article also reported the clinical research results of the spinal cord injury treatment of the collagen nerve regeneration scaffold product ( NeuroRegen Scaffold ) with independent intellectual property rights developed by Dai Jianwu's team , indicating the great potential of the product in the clinical treatment of spinal cord injury .
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New breakthrough in structural biology!
Time of Update: 2021-12-30
As the first member of the SGLT family to be discovered, this protein located on the brush border membrane of the small intestine mucosa transports two sodium ions and one sugar molecule at a time, and the two transport directions are the same, so it is also called a symporter .
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Dong Suwei's team has made progress in the study of glycosylation modification regulation of β amyloid peptide aggregation mechanism
Time of Update: 2021-12-30
In order to further understand the molecular mechanism of glycosylation reducing the stability of Aβ pathological fibers, Dong Suwei’s team worked with Liu Cong’s team at the Intersection Center of Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, and used cryo-electron microscopy to analyze glycoforms with Galβ1-3GalNAc .
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After 18 months of treatment, gene therapy for hemophilia B reaches the primary end point
Time of Update: 2021-12-30
At the 18th month of administration, the annual bleeding rate (ABR) of patients treated with etranacogene dezaparvovec reached the standard of non-inferiority compared with factor IX (FIX) prophylactic treatment .
Retrieved December 9, 2021, from https:// /12/09/2349067/0/en/uniQure-and-CSL-Behring-Announce-Primary-Endpoint-Achieved-in-HOPE-B-Pivotal-Trial-of-Etranacogene-Dezaparvovec-Gene-Therapy-in-Patients -with-Hemophilia-B.
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The affiliated Renji Hospital found that felodipine can prevent and treat bone and joint postoperative implant infections. Classic antihypertensive drugs may become...
Time of Update: 2021-12-30
Recently, Yue Bing’s research group, chief physician of the Department of Orthopedics and Joint Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, published online in the internationally renowned academic journal “Bioactive Materials” about using the clinically classic antihypertensive drug felodipine to effectively solve the problem.
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Which innovative drugs/therapies will bring us surprises and hopes in 2021?
Time of Update: 2021-12-30
With the construction of these platforms, the technical level and standardization of domestic innovative drug research and development have also been improved, and new innovations have continued to emerge .
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Wang Sheng's team collaborates to develop a new generation of anti-schizophrenia lead drugs
Time of Update: 2021-12-30
Based on this structure, Wang Sheng's research group and Cheng Jianjun's research group collaborated to synthesize a new generation of anti-schizophrenia lead drug-IHCH7041, and verified in related mouse models that the drug precursor has antidepressant and improved cognition The potential of obstacles .
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Functional genes significantly associated with ischemic cardiomyopathy
Time of Update: 2021-12-30
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Dai Jianwu's group developed a new type of bifunctional hydrogel scaffold to regulate the immune and inflammatory microenvironment of spinal cord injury, and promote nerve regeneration and functional recovery
Time of Update: 2021-12-30
Transected spinal cord injury mice transplanted with dual-function immunomodulatory hydrogel scaffolds can reduce the secretion of inhibiting pro-inflammatory cytokines in the tissues, regulate the polarization balance of macrophages / microglia, inhibit scar formation, and enhance nerve regeneration and The axon growth ultimately promotes the improvement of SCI electrophysiology and motor function (Figure 2 ) .
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The Chinese University of Science and Technology team reveals a new mechanism for the metabolic enzyme ENO1 to regulate liver cancer
Time of Update: 2021-12-30
Abnormal metabolism is one of the important characteristics of tumors . In recent years, the rapid development of tumor metabolism has greatly expanded people's understanding of metabolic reprogramm
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High-altitude soil carbon in subtropical forests is more sensitive to climate warming
Time of Update: 2021-12-30
In order to answer the response of the decomposition of forest soil organic matter to temperature rise, Zeeshan Mohd, a postdoctoral fellow in the Global Change Research Group of Banna Botanical Garden, under the guidance of co-supervising researcher Sha Liqing, and team members carried out soil carbon emissions along the altitude gradient in Ailao Mountain Response to climate warming .
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Using DNA in the air to monitor insect biodiversity
Time of Update: 2021-12-30
Therefore, the DNA metacode in the air will speed up sampling and allow scientists to expand biodiversity surveys — all without harming the species living there .
"The development of environmental DNA or eDNA is an exciting new technology that provides faster, more sensitive and more powerful tools for biodiversity monitoring .
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Tropical forest tree species rhizosphere and inter-rhizosphere root globulin on soil carbon...
Time of Update: 2021-12-30
Related results were published in the journal Land Degradation & Development with the title Effect of root-glomalin on soil carbon storage in trees' rhizosphere and interspace of a tropical dry forest .
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"Nature" sub-published that a new kind of cancer cells will be dormant or the key to cancer recurrence!
Time of Update: 2021-12-30
According to this line of thinking, if surviving cancer cells can be isolated from patients undergoing chemotherapy, it will be possible to find out which mutations are in the cell population that is resistant to therapy .
