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Research reveals the cell culprit that causes type 1 diabetes!
Time of Update: 2021-12-31
The relevant research results were published online in Nature on November 30, 2021, and the title of the paper is "An autoimmune stem-like CD8 T cell population drives type 1 diabetes" .
An autoimmune stem-like CD8 T cell population drives type 1 diabetes.
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"First-in-class" anemia therapy received FDA priority review qualification
Time of Update: 2021-12-31
Recently, Celgene, a subsidiary of Bristol-Myers Squibb (BMS), announced that the US FDA has granted priority review for the supplementary biological product license application (sBLA) for the "first-in-class" red blood cell maturation agent Reblozyl (luspatercept-aamt) Qualified for the treatment of adult patients with transfusion-independent β-thalassemia .
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The key laboratory has made new progress in the evolutionary mechanism of oyster adaptation
Time of Update: 2021-12-31
In recent days, the authoritative journal Molecular Biology and Evolution field " Molecular Biology and Evolution " Online published a research paper CAS Key Laboratory of Experimental Marine shellfish biology and evolution of genetic research and development team to adapt to high temperature oysters on the mechanism of evolution " noncoding Variation and transcriptional plasticity promote thermal adaptation in oysters by altering energy metabolism" .
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Key laboratory found that deep-sea bacterial polysaccharides inhibit tumor metastasis by targeting type I collagen
Time of Update: 2021-12-31
On August 27 , the international academic journal Journal of Biological Chemistry published an article titled " Marine bacterial exopolysaccharide EPS11 inhibits migration and invasion of liver cance
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New progress has been made in paddy and dryland soil microbial biomass (carbon, nitrogen) content and its environmentally driven differential mechanism
Time of Update: 2021-12-30
Paper link Figure 1 Conceptual framework diagram of influencing factors of differences in soil microbial biomass (carbon, nitrogen) content in paddy fields, paddy-upland rotation and dryland soil
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The Lancet publishes the phased results of the Sichuan University drug weight loss clinical research
Time of Update: 2021-12-30
The team of Associate Professor Li Sheyu from West China Hospital of Sichuan University adopted the latest evidence-based medicine research methods and innovative results visualization model through systematic review and quality evaluation of existing clinical trials of major weight-loss drugs, and independently developed new ones based on the actual situation of the research.
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Important progress has been made in the research on the impact of organic pollutants on the blood-brain barrier
Time of Update: 2021-12-30
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The team of Tian Ying and Gao Yu of the School of Public Health of Science of the Total Environment found the mother...
Time of Update: 2021-12-30
: A Prospective Cohort Study" paper, explored the relationship between PFASs exposure during pregnancy and the growth and development indicators of 0-1 year old infants .
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Suoyuan Biotech and Kaijie have reached a cooperation to help the development of precision tumor therapy
Time of Update: 2021-12-30
DB102 is a small-molecule serine/threonine kinase inhibitor with "first-in-class" potential acquired by Suoyuan Biotech from Eli Lilly and Company, which acts on PKCβ, PI3K and AKT and other tumor fields Key tumor targets .
After the acquisition of DB102, Suoyuan Biosciences used its biomarker discovery platform to discover a new set of biomarkers DGM1.
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Nature Chen Lei's group reported that the hypoglycemic drug Enpagliflozin inhibits human SGLT2-MAP...
Time of Update: 2021-12-30
Although SGLT2 inhibitors have important value in the treatment of type 2 diabetes, it is still unclear how these drugs inhibit the function of SGLT2 protein .
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Synthetic biology makes it possible to "eat biscuits to cure diabetes"
Time of Update: 2021-12-30
Diabetic mice implanted with this engineered cell can increase insulin as long as they eat specific amino acid biscuits.
In their research, diabetic mice implanted with such engineered cells can increase insulin levels and lower blood sugar as long as they eat specific amino acid biscuits .
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Professor Ma Runlin's team from the School of Life Sciences has made important progress in the molecular mechanism of HPV virus carcinogenesis
Time of Update: 2021-12-30
In 2019 , the research team of Professor Ma Runlin of the School of Life Sciences of the University of Chinese Academy of Sciences in the study of the molecular mechanism of HPV virus carcinogenesis revealed for the first time that the high-risk HPV16 virus oncoprotein E7 can directly bind to the host cell microtubule-associated protein 4 ( MAP4 ).
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The latest paper from Zhejiang University: The first report on the feedback mechanism of plant-soil-microbe interaction in plant detoxification technology
Time of Update: 2021-12-30
Although domestic and foreign researchers have conducted a large number of studies on the antiviral mechanism of "detoxification" from multiple perspectives, these studies have focused on the characteristics of plants above ground and have neglected the important characteristics of detoxified seedling cultivation that may be related to underground soil microorganisms .
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"A method for extracting total RNA from tissues with high content of sandalwood essential oil" won the invention patent
Time of Update: 2021-12-30
Extraction of the invention using the method of total sandalwood wood tissue RNA using Nanodrop detected the OD 260.
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[Technology Daily] Gene editing "pipeline" helps prevent and control crop diseases
Time of Update: 2021-12-30
(Photo courtesy of Visual China)The Xie Kabin research group of Huazhong Agricultural University has developed a set of gene editing "pipeline" called "FLASH", which not only optimizes the entire gene editing process, but also can be used to quickly identify the "identity" of gene editing materials and help identify the Genes related to important agronomic traits such as disease resistance, stress resistance, and yield .
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Professor Zhou Pei’s group of Shanghai Jiaotong University has made a major breakthrough in the response of cadmium stress to the super-enriched plant Solanum
Time of Update: 2021-12-30
The previous research of the research group found that under Cd stress, Solanum sinensis can resist the poisoning of Cd by regulating the activity of antioxidant enzymes in the body, the composition of cell wall polysaccharides, the subcellular distribution of Cd, and the chemical form of Cd ( https://doi.
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Who can use special medicine?
Time of Update: 2021-12-30
" Zhang Linqi introduced that from the new crown neutralizing antibody drug, it can target and accurately identify the surface protein of the virus, so that the virus cannot enter the cell .
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Guangzhou Health Institute reveals a new mechanism for mTOR to regulate embryonic stem cell self-renewal
Time of Update: 2021-12-30
Recently, the Qin Baoming Laboratory of the Guangzhou Institute of Biomedicine and Health , Chinese Academy of Sciences revealed a new mechanism of mTOR regulating the self-renewal of embryonic stem cells.
Paper link Guangzhou Health Institute reveals a new mechanism for mTOR to regulate embryonic stem cell self-renewal
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The latest clinical data of the star PROTAC project ARV-471 has obvious safety advantages
Time of Update: 2021-12-30
The study used a conventional 3+3 dose escalation study to evaluate the safety, pharmacokinetics, pharmacodynamics and preliminary effects of oral ARV-471 in pre/postmenopausal women with ER+/HER2-locally advanced or metastatic breast cancer Anti-tumor activity .
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Chinese scholars have made new progress in the synthesis of single-layer nickel and cobalt hydroxide materials
Time of Update: 2021-12-30
The research team established a method of using molecular crystals to directly construct a single layer of nickel hydroxide with an amorphous structure on the surface of the electrode, and revealed its intrinsic catalytic mechanism in the process of electrocatalytic oxygen production .
