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Recently, the Qin Baoming Laboratory of the Guangzhou Institute of Biomedicine and Health , Chinese Academy of Sciences revealed a new mechanism of mTOR regulating the self-renewal of embryonic stem cells.
Embryonic stem cells ( embryonic stem cells, ESC ) have two important characteristics: self-renewal and pluripotency .
2016 years, Bulut-Karslioglu et al found ESC inhibition of rapamycin receptor mechanism ( Mechanistic target of rapamycin, of mTOR ) initiator PAUSE , mainly from the effect of suppressing comprises a plurality of levels, including the whole genome transcription
Using mTORC1 as the entry point, this work reported the role of translation initiation regulation in ESC self-renewal and maintenance of pluripotency
Qinbao Ming led by researchers with the fate of the Laboratory of Cell Metabolism, we had committed early cell and metabolic remodeling the role and mechanism of reprogramming somatic cell study, has found that mTORC1 biosynthesis mediated activation rather than closed autophagic degradation is These remodeling processes are the main reasons for the establishment of induced pluripotent stem cells ( iPSC )
This research was completed by Xu Xueting, a doctoral student jointly trained by Guangzhou Health Institute and University of Science and Technology of China under the guidance of researcher Qin Baoming.
Paper link
Guangzhou Health Institute reveals a new mechanism for mTOR to regulate embryonic stem cell self-renewal
