 Home > Biochemistry News > Biotechnology News > Dai Jianwu's group developed a new type of bifunctional hydrogel scaffold to regulate the immune and inflammatory microenvironment of spinal cord injury, and promote nerve regeneration and functional recovery

Dai Jianwu's group developed a new type of bifunctional hydrogel scaffold to regulate the immune and inflammatory microenvironment of spinal cord injury, and promote nerve regeneration and functional recovery

 Last Update: 2021-12-30
 Source: Internet
 Author: User

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Spinal cord injury causes destruction of axons and death of neurons, ultimately leading to dysfunction

The existing control of microenvironment after spinal cord injury mostly adopts a single strategy, and the effect of regeneration and repair is limited

Figure 1 : Schematic diagram of a dual-functional hydrogel scaffold that regulates the immune-inflammatory microenvironment of spinal cord injury

Studies have shown that photo-crosslinked gelatin hydrogel modified with cationic polymer polyethylenediamine and cytokine can effectively remove DAMP and continuously release IL-10 , reducing the M1 polarization and pro-inflammatory cells of macrophages and microglia Factor secretion, antagonizes DAMPs and inhibits neural stem cell differentiation into nerves

Work related to " A DAMP-scavenging, IL-10-Releasing hydrogel promotes Neural Regeneration and Motor Recovery function the After spinal Cord injury ," the title, was recently published in the "biological material" ( Biomaterials on)

Figure 2 : Dual-function immuno-inflammation regulating hydrogel ( Scav/Delv-GL ) enhances nerve regeneration and promotes functional recovery

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