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The Chinese University of Science and Technology team reveals a new mechanism for the metabolic enzyme ENO1 to regulate liver cancer

 Last Update: 2021-12-30
 Source: Internet
 Author: User

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Abnormal metabolism is one of the important characteristics of tumors

Recently, Zhang Huafeng's research group and Gao Ping's research group (now South China University of Technology) of the University of Science and Technology of China published online in Nature Cancerthe latest research results titled ENO1 suppresses cancer cell ferroptosis by degrading the mRNA of iron regulatory protein 1, reporting ENO1 as The mechanism by which RNA binding protein degrades mRNA has clarified that ENO1 binds to and degrades the mRNA of ironregulatory protein 1 (IRP1 ) gene, thereby regulating the metabolic homeostasis of iron ions in cells, affecting iron death and promoting the occurrence and development of liver cancer.

In this study, the author first discovered that ENO1, which is highly expressed in liver cancer cells, can function as RNA binding protein ( RNA binding protein, RBP ).

Model diagram: Metabolic enzyme ENO1 promotes liver cancer by inhibiting iron death by exerting R NA binding function

Dr.

Original link:https:// class="vsbcontent_end" >

(Department of Life Sciences and Medicine, Department of Scientific Research)

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