 Home > Biochemistry News > Biotechnology News > Wang Enduo teamed up to reveal the molecular mechanism of human-derived DNMT2 recognition substrate tRNA

Wang Enduo teamed up to reveal the molecular mechanism of human-derived DNMT2 recognition substrate tRNA

 Last Update: 2021-12-30
 Source: Internet
 Author: User

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The expression regulation of eukaryotic genes is a very complicated process, involving many aspects such as transcription regulation and translation regulation

DNMT2, a member of the DNA methyltransferase family reported for the first time in 2006, is a tRNA methyltransferase that catalyzes the 38th m ⁵ C modification of the substrate tRNA, but human DNMT2 recognizes the substrate tRNA and catalyzes the m ⁵ C modification.

This study clarified for the first time the molecular mechanism of human-derived DNMT2's recognition substrate tRNA, and found that this mechanism is relatively conserved in higher mammals, providing a theoretical basis for revealing the catalytic function of DNMT2 in mammals

Researcher Wang Enduo from the Center of Molecular Cell Excellence and Professor Liu Rujuan from the School of Life Science and Technology of ShanghaiTech University are the co-corresponding authors of this article, and Wang Enduo's PhD student Huang Zhixuan is the first author

Article link: https://doi.

Schematic diagram of human DNMT2 identifying tRNA substrates

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