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Wang Sheng's team collaborates to develop a new generation of anti-schizophrenia lead drugs

 Last Update: 2021-12-30
 Source: Internet
 Author: User

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With the rapid development of China's economy and society, people's life, work and other pressures have caused the incidence of mental illness to increase year by year

The anti-schizophrenia drugs currently in clinical use can alleviate the positive symptoms, but most anti-schizophrenia drugs have limited or ineffective efficacy in improving negative symptoms and cognitive function

Based on the historical context and pharmacological characteristics of drug development, the current anti-schizophrenia drugs can be divided into three generations

The third-generation anti-schizophrenia drugs-aripiprazole, briprazole and cariprazine, are partial agonists of dopamine D ₂ receptors

Designing drugs with structural information as a guide is a popular route for the research and development of chemical small molecule drugs

Researcher Wang Sheng from the Center of Excellence for Molecular Cells and researcher Cheng Jianjun from the iHuman Institute of ShanghaiTech University are the co-corresponding authors of the paper

Article link: https://

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