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PNAS China University of Science and Technology Tao Yuyong/Li Xu team made a breakthrough in the research on the intracellular-extracellular information transmission mechanism of Staphylococcus aureus
Time of Update: 2022-01-25
On the basis of the above structural findings, the Tao Yuyong /Li Xu team combined the biochemical and growth analysis of HptA and HptS mutants, and proposed the interface switch-mediated G6P-HptRSA signaling mechanism .
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Plant-unique transcriptional machinery: the Pol IV-RDR2 complex cooperates to synthesize double-stranded RNA
Time of Update: 2022-01-25
Based on this, the researchers proposed a model in which the Pol IV-RDR2 complex uses the mechanism of internal RNA delivery to realize the synthesis of double-stranded RNA from double-stranded DNA as a template .
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Lactobacillus plantarum concubine strain added to the fight against the new crown can significantly improve the effectiveness of the vaccine
Time of Update: 2022-01-25
The researchers found that oral administration of Lactobacillus plantarum GUANKE (LPG) to mice 24 weeks after inoculation with the new crown vaccine significantly enhanced and prolonged the new coronavirus-specific memory antibody response .
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How is memory stored in the brain, and how does it potentially impact conditions such as PTSD?
Time of Update: 2022-01-25
Through a multidisciplinary collaboration of the USC Viterbi School of Engineering and the Southern California College of Arts and Sciences, the College of Arts and Sciences team was able to determine the strength and location of the first synapses in the brain before and after learning in the living zebrafish, an animal commonly used to Study brain function .
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Ji Hongbin's group cooperated to reveal the mechanism of metastasis caused by the transformation of small cell lung cancer cell subtypes
Time of Update: 2022-01-25
In this work, the researchers revealed the key molecule TAZ that regulates the transformation and metastasis of small cell lung cancer cell subsets and its mechanism of action .
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New transplant strategy may improve outcomes for blood stem cell recipients
Time of Update: 2022-01-25
Image: Warren Shlomchik, MD, Director of the Hematopoietic Stem Cell Transplantation and Cell Therapy Program at UPMC Hillman Cancer Center and Professor of Medicine and Immunology at the University of Pittsburgh School of MedicineRemoving a type of T cell from a donor's blood used for stem cell transplants can dramatically reduce a serious complication known as graft-versus-host disease in leukemia patients, according to a new study .
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A non-equilibrium mechanism of bacterial flagellar motor switches
Time of Update: 2022-01-25
By further comparing the previous results of dynamic characteristics under other loads, the researchers propose a new mechanism whereby the asymmetrical torque when the motor rotates clockwise and counterclockwise provides an unbalanced energy input for motor switching .
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Researchers discover new mechanism for deadly blood clots
Time of Update: 2022-01-25
In the lab, the team tested its effects, and its potential as a therapeutic target for preventing blood clots or identifying people at high risk .
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Scientists map skin cells that cause diabetic foot ulcers
Time of Update: 2022-01-25
Scientists have mapped the cellular landscape in the treatment of diabetic foot ulcers and non-healers using a cutting-edge technique called single-cell RNA-sequencing analysis, which provides deep insight into cellular function and disease development, revealing that gene expression in individual cells in tissues is determined by various types of cells .
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Boosting a gene in brain helper cells slows Alzheimer's progression
Time of Update: 2022-01-25
To investigate how persistent activation of Nrf2 in astrocytes protects the brain, Johnson's lab bred mice to over-accumulate beta-amyloid around neurons to mimic Alzheimer's disease, and A large amount of Nrf2 is expressed in astrocytes .
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New bacteria appear in UK waters as temperatures rise
Time of Update: 2022-01-25
""Vibrio alginolyticus, which can also cause disease in humans, was found at three sites with sea surface temperatures exceeding 18°C (Chichester Harbour, Ossie Island and Whitstable Bay) .
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Professor Deng Xianming's research group published a paper in "EMBO Mol Med" to report a new generation of ALK inhibition...
Time of Update: 2022-01-25
On November 30, 2021, the research group of Professor Deng Xianming from the State Key Laboratory of Cellular Stress Biology, the National and Local Joint Engineering Laboratory for Targeted Drugs from Natural Product Sources, and the School of Life Sciences of Xiamen University jointly published a title in "EMBO Molecular Medicine" For the research paper "A new ALK inhibitor overcomes resistance to first- and second-generation inhibitors in NSCLC" ( http://doi.
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Can losing weight fix the brain?
Time of Update: 2022-01-25
Now, researchers at Karolinska Institutet have shown that neurological recovery after stroke is significantly improved in obese and diabetic mice, which lost weight and returned to normal levels of glucose metabolism .
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Jiang Peng's research group from the School of Life Sciences reports that citrulline metabolism regulates the inflammatory response of macrophages
Time of Update: 2022-01-25
A recent study by Jiang Peng's group at the School of Life Sciences, Tsinghua University revealed that abnormal changes in the urea cycle significantly affect the ammonia metabolism and polyamine biosynthesis ability of tumor cells (Li et al.
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UK NICE recommends Merck's Keytruda combination therapy for first-line treatment of NSCLC
Time of Update: 2022-01-25
CompilationFan DongdongA few days ago, NICE in the United Kingdom recommended Merck Keytruda in combination with the chemotherapy carboplatin and paclitaxel for the treatment of untreated metastatic squamous non-small cell lung cancer (NSCLC) .
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New neural circuit discovery regulates spatial learning and memory in brain's hippocampus
Time of Update: 2022-01-25
The study, "Non-canonical projections to the hippocampal CA3 regulate spatial learning and memory by modulating the feedforward hippocampal trisynaptic pathway," is published today in the journal PLOS Biology .
Noncanonical projections to the hippocampal CA3 regulate spatial learning and memory by modulating the feedforward hippocampal trisynaptic pathway .
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Wuhan Botanical Garden has completed the chloroplast genes of two unique national-level protected plants in my country - Palmetto and Umbra...
Time of Update: 2022-01-25
Researchers at the Wuhan Botanical Garden assembled the chloroplast genomes of Palmarina and Umbellifera by shallow genome sequencing technology, whose sizes were 151,271 bp and 158,690 bp , respectively, and the chloroplast genome sizes were consistent with the previously reported laws .
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"Desert Ornamental Plant Introduction and Breeding Technology" published
Time of Update: 2022-01-25
TRS_Editor A{margin-top:0px;margin-bottom:15px;line-height:2;font-family:;font-size:12pt;}</> Recently, the book "Desert Ornamental Plant Introduction and Breeding Technology", edited by Fan Jinglong and Chang Qing, senior engineers of Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, and Tashigan Gapar as a contributing editor, was published .
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China University of Science and Technology Dynasty Research Group has made progress in the study of the mechanism of Ephexin family protein auto-inhibition and activation
Time of Update: 2022-01-25
Recently, Professor Wang Chao's research group from the Department of Life Science and Medicine of the University of Science and Technology of China and Professor Zhu Jinwei 's research group from the Bio-X Research Institute of Shanghai Jiao Tong University jointly published a research paper titled Double inhibition and activation mechanisms of Ephexin family RhoGEFs on PNAS online , revealing for the first time Molecular mechanism of dual autoinhibition and activation of Ephexin family RhoGEF .
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Migration of influenza virus nucleoproteins to the nucleolus is critical for the formation of ribonucleoprotein complexes
Time of Update: 2022-01-25
Furthermore, nucleolar disruption in virus-infected cells inhibits the assembly of NPs into duplex RNPs, resulting in a marked reduction in viral RNA synthesis and replication .
