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Jiang Peng's research group from the School of Life Sciences reports that citrulline metabolism regulates the inflammatory response of macrophages

 Last Update: 2022-01-25
 Source: Internet
 Author: User

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Macrophages are an important part of the body's anti-infection immune system, and the immune function of macrophages is affected by changes in intracellular and extracellular metabolites
.

Arginine metabolism has long been recognized as an important metabolic regulator regulating macrophage polarization and inflammatory responses

A recent study by Jiang Peng's group at the School of Life Sciences, Tsinghua University revealed that abnormal changes in the urea cycle significantly affect the ammonia metabolism and polyamine biosynthesis ability of tumor cells (Li et al.

2019, Nature ), which is different from tumor cells

On January 10, 2022, the research group published an article titled " Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune response by ASS1-mediated citrulline depletion in the journal Molecular Cell .
macrophage activation and immune responses )” research paper
.

In this work, we reveal the important role of the urea cycle metabolizing enzyme ASS1 and its substrate citrulline in innate immune responses

Taken together, this work reveals a central role for ASS1 in controlling inflammatory macrophage activation and antimicrobial defense by depleting cellular citrulline, further identifying citrulline as an innate immune signaling metabolite involved in pro-inflammatory responses.
metabolic checkpoints
.

Figure 1.
ASS1-mediated depletion of citrulline directly regulates pro-inflammatory activation and immune function in macrophages

Mao Youxiang, a 2016 doctoral student at the School of Life Sciences of Tsinghua University, is the first author of the paper, and Jiang Peng, a researcher at the School of Life Sciences and the Joint Center for Life Sciences of Tsinghua University, is the corresponding author of the paper
.

This project was funded by the Tsinghua-Peking University Life Joint Center and the National Natural Science Foundation of China

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