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Nature sub-published paper reveals complexity of vitamin B12 disease
Time of Update: 2022-01-25
"Some patients with cblC-like diseases may respond to cobalamin supplements to some extent, but we do not expect this to help with the problems caused by ribosome defects," Poché said .
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The Institute of Hydrobiology has made continuous progress in aquatic virology research
Time of Update: 2022-01-25
Recently, the Department of Aquatic Virology, Institute of Hydrobiology, Chinese Academy of Sciences, based on the establishment of a high-efficiency frog virus recombination, gene replication and functional testing system, as well as the isolation of specific proteins from the nascent DNA of fish cells, recombinant virus affinity chromatography and nano -luciferase NanoLuc complementation and mass spectrometry analysis technology identified and revealed the organization structure and related mechanism of frog virus replication and transcription machinery .
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Zhou Rongjia/Cheng Hanhua's research group's research review on Eel's sexual reversal
Time of Update: 2022-01-25
015) published online a review paper by Professor Zhou Rongjia/Cheng Hanhua's research group from the School of Life Sciences, entitled "Decoding genome recombination and sex reversal" ( DOI: 10.
Decoding the eel genome recombination and sexual reversal
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Protein Amplification Technology: New Advances in the Diagnosis of Human Prion Diseases
Time of Update: 2022-01-25
PMCA has high diagnostic accuracy in blood, cerebrospinal fluid, and urine samples from patients with variant Creutzfeldt-Jakob disease (vCJD) .
Likewise, RT-QuIC showed high diagnostic accuracy for cerebrospinal fluid, olfactory mucosa, and skin samples from patients with sporadic Creutzfeldt-Jakob disease (sCJD) .
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China University of Science and Technology Dynasty Research Group has made progress in the study of the mechanism of Ephexin family protein auto-inhibition and activation
Time of Update: 2022-01-25
Recently, Professor Wang Chao's research group from the Department of Life Science and Medicine of the University of Science and Technology of China and Professor Zhu Jinwei 's research group from the Bio-X Research Institute of Shanghai Jiao Tong University jointly published a research paper titled Double inhibition and activation mechanisms of Ephexin family RhoGEFs on PNAS online , revealing for the first time Molecular mechanism of dual autoinhibition and activation of Ephexin family RhoGEF .
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A real paradigm shift!
Time of Update: 2022-01-25
Experts have found that mutations that occur when the DNA of both parents is replicated during reproduction can cause male infertility later in life .
"However, our study found that mutations that occur when parents replicate their DNA during reproduction play an important role in the infertility of their sons .
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Peking University scholar NAR publishes paper: Development of RNA nanomaterials that interfere with HIV-1 virus assembly
Time of Update: 2022-01-25
Self-assembly of multiple oligonucleotides with hairpin structures to obtain nanostructures that interfere more with HIV-1 assemblyQu Na, a graduate doctoral student in Chen Kuangshi's research group, is the first author of this work.
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Intermittent protein restriction can intervene in diabetes and protect islet beta cells
Time of Update: 2022-01-25
On December 31, 2021, Chen Yan's research group from Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences published a research titled "Intermittent protein restriction protects islet beta cells and improves glucose homeostasis in diabetic mice" online in the international academic journal Science Bulletin .
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"Nature Methods" The world's smallest antenna - DNA
Time of Update: 2022-01-25
Like a two-way radio that can both receive and transmit radio waves, a fluorescent nanoantenna designed by Alexis Vallée-Bélisle and his team receives one color of light, senses protein movement based on it, and transmits the light back to another colors that we can detect .
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First evidence that neutrophil behavior damages cardiovascular cells
Time of Update: 2022-01-25
Andrés Hidalgo at the Cardiovascular Research Center (CNIC) have discovered that circulating neutrophils, a type of immune cell, acquire different behavioral patterns during inflammation .
"Several studies have shown that the presence of neutrophils in the blood is associated with higher risk and severity of cardiovascular disease," said first author Georgiana Crainiciuc .
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Migration of influenza virus nucleoproteins to the nucleolus is critical for the formation of ribonucleoprotein complexes
Time of Update: 2022-01-25
Furthermore, nucleolar disruption in virus-infected cells inhibits the assembly of NPs into duplex RNPs, resulting in a marked reduction in viral RNA synthesis and replication .
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The scientific research results of Li Guoxin's team were published in the top international journals of materials science
Time of Update: 2022-01-25
Recently, the paper "H 2 O 2 Self-Producing Single-Atom Nanozyme Hydrogels as Light-Controlled Oxidative Stress Amplifier for Enhanced Synergistic Therapy by Transforming "Cold" Tumors" by Li Guoxin and Zhu Daoming's team from the General Surgery Department of Nanfang Hospital was published as a research paper (Research Article ) was published online in Advanced Functional Materials , the top international journal of materials science .
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Intestinal flora hides "Jianghu", ribosomal peptide cleverly acts as "killer"
Time of Update: 2022-01-25
The Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences (hereinafter referred to as the "Institute of Synthesis") , in cooperation with the research group and Wang Huan's research group from the School of Chemistry and Chemical Engineering, Nanjing University , published a paper entitled Biosynthesis of Article by Gut-Microbiota-Derived Lantibiotics Reveals a Subgroup of S8 Family Proteases for Class III Leader Removal .
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How do the locus coeruleus in the brain help us focus quickly?
Time of Update: 2022-01-25
Researchers at the Max Planck Institute for Human Development and the University of Southern California have developed a new model that describes how the locus coeruleus modulates our brain's sensitivity to relevant information in situations where attention is required .
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Rising star: 'pan' COVID-19 ferritin nanoparticle vaccine
Time of Update: 2022-01-25
A series of recently published preclinical studies have shown that the spike ferritin nanoparticle (SpFN) COVID-19 vaccine developed at the Walter-Reed Army Research Institute (WRAIR) in the United States not only elicits an effective immune response, but also May offer broad protection against worrying variants of SARS-CoV-2 and other coronaviruses .
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USTC successfully reveals the druggable "cryptic state" of the oncogene protein Ras
Time of Update: 2022-01-25
Recently , the research group of Professor Long Dong from University of Science and Technology of China has made important progress in the research of oncogene protein Ras microsecond timescale dynamics and druggable " cryptic state " .
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Liu Min and Chen Ruichuan's team published a paper in the journal "Nucleic Acids Research", revealing...
Time of Update: 2022-01-25
Recently, the team of Assistant Professor Liu Min and Professor Chen Ruichuan published a study titled "Disrupting the Cdk9/Cyclin T1 Heterodimer of 7SK snRNP for the Brd4 and AFF1/4 Guided Reconstitution of Active P-TEFb" in the journal "Nucleic Acids Research".
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On January 7, the world's first pig heart transplant was successful!
Time of Update: 2022-01-25
Gene modification is the use of molecular biology techniques to remove parts of animal genes that are prone to rejection, so that the transplanted animal organs can be compatible with the human body and survive for a long time .
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China University of Science and Technology Liu Qiang's team has made important progress in the field of Alzheimer's disease research
Time of Update: 2022-01-25
On January 26, 2021, Liu Qiang's team from the University of Science and Technology of China published a research paper titled " Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory " in the journal Neuron , revealing the effect of ApoE on neuronal cholesterol The mechanism of metabolic reprogramming and the impact of this metabolic regulation on neuronal function, especially learning and memory processes, also revealed a new mechanism by which ApoE4 causes Alzheimer's disease .
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Neurons from stem cells can predict psychosis and cognitive deficits in schizophrenia, new study finds
Time of Update: 2022-01-25
That said, no other study has shown a strong link between neural models derived from a patient's stem cells and clinically relevant features of the same person's psychiatric disorder .
