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On December 31, 2021, Chen Yan's research group from Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences published a research titled "Intermittent protein restriction protects islet beta cells and improves glucose homeostasis in diabetic mice" online in the international academic journal Science Bulletin
.
The study found that intermittent protein restriction protects pancreatic beta cells and improves blood glucose homeostasis in diabetic mice
Diabetes, especially type 2 diabetes, has become one of the greatest health challenges facing humanity in the 21st century
.
Type 2 diabetes is often caused by an unhealthy life>
In addition to protein- or amino-acid-restricted dietary strategies, fasting or caloric restriction has long been recognized as an effective means of extending lifespan and improving metabolic health
.
In recent years, many caloric restriction modalities such as intermittent dieting and time-restricted diet have been widely used to improve metabolic diseases including diabetes
Although continuous protein or amino acid restriction and intermittent dieting have been shown to improve diabetes, no studies have examined whether intermittent protein restriction is sufficient to intervene in diabetes
.
This study investigated an intermittent protein restriction (IPR) diet and found that IPR rapidly alleviated hyperglycemia in STZ-induced type 1 diabetic mice and leptin receptor deficiency-induced type 2 diabetic mice
Researcher Chen Yan from Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences is the corresponding author of the paper, and doctoral students Wei Siying and Li Chenchen are the co-first authors of the paper
.
This work was supported by the Ministry of Science and Technology, the National Natural Science Foundation of China and other funds, as well as the public technology platform and animal platform of the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences
Original link: https://doi.
