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Nearly 80 percent of people who die from type 2 diabetes (T2DM) are associated with thrombosis, a condition in which a blood clot blocks a vein or artery
"One of our goals was to identify human markers of disease, which would allow us to characterize disease with greater resolution
The researchers, including first author Wandi Zhu, Ph.
The researchers also looked at what would happen if this mechanism was inhibited
The authors note that more research is needed before this work can be translated into clinical applications
There's still a lot to learn, but the project's approach, starting with clinical patients, has the potential to accelerate discovery and have clinical impact, MacRae noted
"We're still learning a lot of new things about disease that we think we already fully understand," McRae said