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The 5-year survival rate of patients with small cell lung cancer is about 7%, which is closely related to its high metastasis
TAZ activation can inversely promote the transition of the NCAM hi CD44 lo/- subset to the NCAM lo CD44 hi subset, thereby inhibiting the metastasis of small cell lung cancer
Analysis of public single-cell sequencing data showed that the majority of tumor cells in small cell lung cancer metastases exhibited NCAM hi CD44 lo/- signatures
This study lays a solid theoretical foundation for an in-depth understanding of the metastasis mechanism of small cell lung cancer
This work was supported by Researcher Liu Xinyuan, Researcher Chen Luonan, Researcher Zhu Xueliang, Researcher Zhang Lei, and Researcher Gao Dong, Professor Zhang Peng of Pulmonary Hospital, Professor Jiang Liyan of Shanghai Jiaotong University, and Researcher Qin Jun of Institute of Nutrition and Health, Chinese Academy of Sciences, Supported by Prof.
Small cell lung cancer is the most malignant subtype of lung cancer and is prone to distant metastasis
.
The 5-year survival rate of patients with small cell lung cancer is about 7%, which is closely related to its high metastasis
Mechanistic studies have found that with the malignant progression of small cell lung cancer, the core molecule TAZ of the Hippo signaling pathway is regulated by the chromatin remodeling complex SWI/SNF and down-regulated, triggering the transition from the NCAM lo CD44 hi subset to the NCAM hi CD44 lo/- subset.
, and ultimately promote the metastasis of small cell lung cancer
.
TAZ activation can inversely promote the transition of the NCAM hi CD44 lo/- subset to the NCAM lo CD44 hi subset, thereby inhibiting the metastasis of small cell lung cancer
Findings in these animal models are further supported by clinical data
.
Analysis of public single-cell sequencing data showed that the majority of tumor cells in small cell lung cancer metastases exhibited NCAM hi CD44 lo/- signatures
In conclusion, this study found that the NCAM hi CD44 lo/- subset is responsible for the metastasis of small cell lung cancer, which is derived from the transformation of cell subsets caused by the down-regulation of TAZ, and TAZ plays an important role in the transformation of cell subsets and the metastasis of small cell lung cancer.
Molecular switch action
.
This study lays a solid theoretical foundation for an in-depth understanding of the metastasis mechanism of small cell lung cancer
Associate Professor Jin Yujuan, Dr.
Zhao Qiqi, and Dr.
Feng Yan of the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Zhu Weikang, Institute of Mathematics and Systems Biology, Chinese Academy of Sciences, and Associate Professor Xiao Tian, Shenzhen University are the co-first authors of the paper; Molecular and Cell Science, Chinese Academy of Sciences Researcher Ji Hongbin, associate researcher Hu Liang and researcher Wang Yong of the Institute of Mathematics and Systems Science of the Chinese Academy of Sciences are the co-corresponding authors of the paper
.
This work was supported by Researcher Liu Xinyuan, Researcher Chen Luonan, Researcher Zhu Xueliang, Researcher Zhang Lei, and Researcher Gao Dong, Professor Zhang Peng of Pulmonary Hospital, Professor Jiang Liyan of Shanghai Jiaotong University, and Researcher Qin Jun of Institute of Nutrition and Health, Chinese Academy of Sciences, Supported by Prof.
Article link: https://academic.
Pattern map of TAZ regulating the transformation and metastasis of small cell lung cancer subsets
