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Analysis of sperm can uncover rare genetic variants
Time of Update: 2022-03-04
Researchers at Karolinska Institutet analyzed blood and sperm samples from healthy parents to children with genetic syndromes and found that germline mosaicism is underestimated as a cause of syndromes with high levels of genetic variation in sperm.
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Deprive leukemia cells of energy
Time of Update: 2022-03-04
Jérôme Tamburini explained: "Following this initial proof-of-principle, we must decipher the biochemical mechanisms at work in order to understand them in detail, and in particular which cellular pathways are activated by GSK621 in leukemia cells, which is hoped to exploit this phenomenon for The first step in treatment .
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What are the characteristics of the increasing number of early-onset colorectal cancer?
Time of Update: 2022-03-04
Strengthen precise screening of high-risk groups and general population screeningAbout 16% of patients with early-onset colorectal cancer have an associated genetic syndrome, and another 25% have a family history of CRC, who can be screened early according to current screening guidelines in the United States and the United Kingdom .
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Today's "Cell": Fungus in the gut can also affect behavior?
Time of Update: 2022-03-04
Under the action of fungi, these T cells secrete two immune signaling proteins: one is IL-22, which acts locally on epithelial cells and enhances the barrier function of the gut; the other is IL-17, which further enters The blood circulates, and eventually reaches the brain, where it acts on neurons that influence the social behavior of mice .
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Eisai Lenvima combined with Keytruda for bladder cancer fails to prolong patient's life!
Time of Update: 2022-03-04
In this regard, Ebbinghaus pointed out that about one-fifth of bladder cancer patients cannot receive any platinum-based chemotherapy, and Merck Keytruda's performance in the LEAP-011 clinical trial was comparable to the drug's performance in the phase 2 KEYNOTE-052 clinical trial.
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Legend Bio's CAR-T therapy clinical trial was halted by FDA
Time of Update: 2022-03-04
In addition to this early-stage treatment program, Legend has a key partnership with Johnson & Johnson to work on cilta-cel, a CAR-T cell therapy for multiple myeloma, which is expected to be approved this month .
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Using DNA data to drive conservation efforts
Time of Update: 2022-03-04
Dr Evelyn Jensen, Lecturer in Molecular Ecology at Newcastle University's School of Natural and Environmental Sciences, who led the study, said: "While genetic diversity has grown since the first Convention on Biological Diversity (CBD) in 1993, Recognized as a key component of biodiversity, yet it is rarely incorporated into conservation policies and regulations .
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Reviewing the Long Sequencing Road in Twenty Years (1): Insect Genomics
Time of Update: 2022-03-04
As Washington State University postdoc Scott Hotaling noted in his review of 20 years of insect genome sequencing, "We have entered a new era of insect genome biology .
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Five invention patents of Wuhan Botanical Garden are granted authorization
Time of Update: 2022-03-04
2 Inventors: Liang Qiong , Zhang Yanjun, Yu Shuxia, Huang Tianyue, Yu Dongyue, Wang Lanxiang Patentee: Wuhan Botanical Garden, Chinese Academy of Sciences Authorization date: 2022-01-21 The invention relates to the technical field of plant tissue culture, and discloses a tissue culture and rapid propagation method of Epimedium sagittae The process of culturing, inducing explants to form callus, inducing callus to differentiate into adventitious buds or clustered buds, inducing buds to form fibrous roots, refining seedlings, and raising seedlings, etc.
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A new set of protein switches discovered in a sub-journal of Nature
Time of Update: 2022-03-04
A team of researchers at the University of Göttingen in Germany initially discovered a new protein switch -- dubbed the "NOS switch" because nitrogen, oxygen and sulfur atoms are linked to each other -- in a protein derived from the human pathogen Neisseria gonorrhoeae in protein .
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Ning Jieyuan's research group from the School of Earth and Space confirms the existence of Doppler effect in the seismic wave field of high-speed railways
Time of Update: 2022-03-04
The research results were published in the third issue of the Chinese and English editions of "Science China: Earth Science" in 2022 under the title " Doppler Effect and Application in High-speed Railway Seismic Wavefields ", and was selected as the cover article (Figure 1) .
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A new PARP-like enzyme discovered in mitochondria
Time of Update: 2022-03-04
To characterize the enzymatic activity of NEURL4, a team led by first and co-corresponding author Maria Dafne Cardamone, Ph. D.
The researchers believe that future studies of how NEURL4-mediated modification of specific mitochondrial proteins affects mitochondrial function may lead to the identification of new regulatory strategies for therapeutic purposes .
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Progress in the study of extreme precipitation changes in the Tianshan Mountains of Central Asia and their associated large-scale climate teleconnection indices in Xinjiang habitats
Time of Update: 2022-03-04
TRS_Editor A{margin-top:0px;margin-bottom:15px;line-height:2;font-family:;font-size:12pt;}</> Extreme precipitation (EP) often causes floods, landslides, mudslides and other natural disasters, posing a huge threat to human society .
The frequency changes, and based on the geographic detector (GMD), quantitatively evaluate the large-scale climate teleconnection index that is the most critical to the impact of EP .
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Depression and Alzheimer's disease share genetic roots
Time of Update: 2022-03-04
Co-senior author Aliza Wingo, MD, of Emory University School of Medicine in Atlanta, USA, said of the study: "It raises the possibility that there are genes that cause both diseases .
"This study sheds light on the genetic-level relationship between depression and Alzheimer's disease and related dementias," said senior co-author Thomas Wingo, MD .
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A common denominator in degenerative diseases: cells have mechanisms to clear aggregates, but fail to activate
Time of Update: 2022-03-04
In cells with huntingtin-related protein aggregates, the cells sensed something was wrong and activated some stress response partners, but not correctly .
For ALS-associated aggregates, the situation was even worse; the cells simply didn't realize they needed to activate a partner and showed no signs of stress .
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The team of Professor Xia Ningshao and Professor Guan Yi of the University of Hong Kong jointly made the latest progress in the direction of anti-inflammatory treatment of COVID-19
Time of Update: 2022-03-04
Recently, a joint research team from the National Research Center for Infectious Disease Diagnostic Reagents and Vaccine Engineering Technology and the University of Hong Kong discovered through a series of animal experiments that progesterone (a major estrogen) plays an important role in protecting female hamsters from severe COVID-19.
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Viral liver cancer vs non-viral liver cancer: Can PD-1 therapy be a one-size-fits-all approach?
Time of Update: 2022-03-04
In a preclinical model of NASH-HCC, the use of PD-1 inhibitors increased the number of activated CD8+PD1+ T cells in the tumor, but did not cause tumor regression, suggesting impaired tumor immune surveillance .
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Shanghai Jiaotong University Yang Litao team developed a new method Cas-PfLAMP for rapid field detection of rice pathogens
Time of Update: 2022-03-04
Recently, Yang Litao's research group from Zhang Dabing's team from Shanghai Jiaotong University's School of Life Science and Technology published a paper entitled "PAM-free Loop-mediated Isothermal A
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The placenta is key to early diagnosis and intervention
Time of Update: 2022-03-04
"Through an unbiased investigation of placental DNA methylation differences, we have uncovered an autism-associated genome in an autism-associated genome," said study lead author Janine LaSalle, a professor of microbiology and immunology at UC Davis.
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Professor Zhu Jianwei's team from Shanghai Jiaotong University discovered broad-spectrum neutralizing antibodies against SARS-CoV-2
Time of Update: 2022-03-04
After the outbreak of the new crown epidemic, the team of Professor Zhu Jianwei of the Engineering Research Center for Cell Engineering and Antibody Drugs of the Ministry of Education cooperated with many domestic and foreign enterprises and institutions to clone and screen the B cells of recovered patients to obtain a number of SARS-CoV-2 viruses.
