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To characterize the enzymatic activity of NEURL4, a team led by first and co-corresponding author Maria Dafne Cardamone, Ph.
According to the researchers, this approach allowed them to identify a number of mitochondrial proteins as targets of NEURL4, including mitochondrial LIG3, a protein involved in the repair of damaged mitochondrial DNA, and confirmed that the activity of NEURL4 is to maintain mitochondrial DNA (mtDNA) required for completeness
While the study does not have any immediate implications for clinical treatment, the team said it represents an important step in understanding how cells maintain homeostasis and respond to oxidative stress
The researchers believe that future studies of how NEURL4-mediated modification of specific mitochondrial proteins affects mitochondrial function may lead to the identification of new regulatory strategies for therapeutic purposes
Maria Dafne Cardamone, Yuan Gao, Julian Kwan, Vanessa Hayashi, Megan Sheeran, Junxiang Xu, Justin English, Joseph Orofino, Andrew Emili, Valentina Perissi.
