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Huntington's, Alzheimer's, amyotrophic lateral sclerosis, and a variety of other neurodegenerative diseases have one thing in common: they are all characterized by proteins that aggregate in neurons of the brain and nervous system (each different proteins in different diseases)
Proteins are the building blocks and functional units of our bodies
Aggregates form when certain proteins form incorrectly
How do we know what a cell is feeling? We can't ask if it's pleasure or pain
Some of the cell's response to stress is to activate specific chaperones in an attempt to correct or remove misfolded proteins
So, if the necessary partners exist, why can't they heal the patient's cells before the neurons degenerate? "It's not enough to just have the tools in the cell's toolbox," Shaggy said
Unfortunately, the team found, this is where the bottleneck lies
"A cell is a complex system," said Prof Sharkey, explaining the surprising finding
article title
Differential roles for DNAJ isoforms in HTT-polyQ and FUS aggregation modulation revealed by chaperone screens