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The team of Fan Dongsheng from Peking University Third Hospital was invited to comment on the global research progress of amyotrophic lateral sclerosis in The Lancet Neurology
Time of Update: 2022-04-18
Professor Fan Dongsheng's team has been engaged in basic and clinical research on amyotrophic lateral sclerosis for a long time, and has done a lot of original work in many fields such as pathogenesis, electrophysiological diagnostic methods, natural history of the disease, and clinical trials, and the research results have reached the international advanced level.
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Cell Wei Wensheng's research group reported the circular RNA technology platform and the new anti-new coronavirus vaccine developed accordingly
Time of Update: 2022-04-18
On March 31, 2022, Peking University Wei Wensheng's research group published a research paper online entitled Circular RNA Vaccines against SARS-CoV-2 and Emerging Variants in the journal Cell , reporting the circular RNA vaccine technology platform for the first time, and the development of the technology based on it.
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The team of Professor Fang Wentao of the Affiliated Chest Hospital released the world's first postoperative recurrence prediction model for thymic tumors
Time of Update: 2022-04-18
Based on the analysis of the Chinese population for the first time, the research results put forward the world's first recurrence prediction model of thymic tumor and its significance for long-term management of prognosis, providing more powerful clinical guidance and management model for the management of thymic tumor patients in China and the world.
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The climate sensitivity of radial growth of two pine trees in Yunnan varies with temperature and water...
Time of Update: 2022-04-17
Figure: Spatial distribution of correlation coefficients between tree growth and seasonal climate variables in the early and late growing seasons of Pinus yunnanensis and Pinus simao in Southwest China .
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Fifteen years of research on the mechanism of [5+2+1] reaction by Yu Zhixiang's research group in the School of Chemistry has made progress
Time of Update: 2022-04-17
Transformation between dormant dinuclear and mononuclear catalytic species (Image credit: JACS )The research group used meticulous computational chemistry method benchmark studies to evaluate the performance of different computational methods in predicting the thermodynamics and kinetics of the rhodium-catalyzed cycloaddition reaction elementary steps, and finally decided to use the BMK functional and DLPNO-CCSD(T), respectively.
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Combining two molecules blocks 95 percent of live viral infections in lung cells
Time of Update: 2022-04-17
But now, two Université de Montréal professors working at the Montreal Clinical Research Institute (IRCM) have taken a giant step forward in understanding the coronavirus: they have discovered and demonstrated the power of two small molecules that can stop the virus that causes COVID-19 SARS-CoV-2 infects cells in the lungs .
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HIV drug stabilizes metastatic colorectal cancer
Time of Update: 2022-04-17
"This provides evidence that HIV drugs can be repurposed as anticancer treatments in patients with metastatic cancer," Ting said .
Although not confirmed or evaluated in this trial, Ting believes that combining reverse transcriptase inhibitor therapy with immunotherapy may promote immune cell involvement in these cancers .
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New 3D map reveals cellular structure of the human posterior thalamus
Time of Update: 2022-04-17
"New deep learning-based methods are used to understand the topography and cellular structure of the hypothalamus" continues Kai Kiwitz of the Cécile and Oskar Vogt Brain Institute, Düsseldorf University Hospital .
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Cai Huaqing's research group reveals the molecular mechanism of macropinosome maturation
Time of Update: 2022-04-17
On April 4, 2022, Huaqing Cai's group from the Institute of Biophysics, Chinese Academy of Sciences published a research paper titled "The PripA-TbcrA complex-centered Rab GAP cascade facilitates macropinosome maturation in Dictyostelium " in the journal " Nature Communications " , which revealed that giant cells Molecular mechanism of the regulation of macropinosome maturation and cargo degradation by the Rab GAP signaling cascade composed of Rab5, Rab7, PripA and TbcrA during body maturation .
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Guangzhou Health Institute has made progress in the research on the mechanism of chromatin advanced structure regulating cell fate
Time of Update: 2022-04-17
Fu Xiangdong's research group from University of California, San Diego published a paper entitled CTCF functions as an insulator for somatic genes and a in Cell Reports.
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Nat. Commun. Interaction patterns between interstitial cells and macrophages in colorectal cancer tumor borders
Time of Update: 2022-04-17
Youqiong Ye from Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine published a research titled Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer in Nature Communications thesis .
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Chinese scholars propose a new mechanism for the origin of "initial oxygen" in the early Earth
Time of Update: 2022-04-17
Evolutionary pressure on the formation of cyanobacterial ancestors by reactive oxygen species (H 2 O 2 and O 2 ) at the mineral-water interface The successful evolution of oxygen-producing photosynthesis in the ancestors of cyanobacteria that occurred between 2.
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Epigenetic studies provide new insights into the origin of gliomas
Time of Update: 2022-04-17
One of these molecules, enhancer RNA, is sufficient to turn on miR-10b and multiple HOXD genes, promoting cancer growth; inactivating the molecule in glioma cells reduces glioma viability .
"Promoter and enhancer RNAs regulate chromatin reorganization and activation of miR-10b/HOXD locus, and neoplastic transformation in glioma
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Molecular mechanism of cytotrophic state feedback regulation of macropinocytosis
Time of Update: 2022-04-17
On April 1, 2022, Huaqing Cai's group from the Institute of Biophysics, Chinese Academy of Sciences published a research paper titled "Oligopeptide transporter Slc15A modulates macropinocytosis in Dictyostelium by maintaining intracellular nutrient status" in the Journal of Cell Science .
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Ascletis Pharma's 2nd FASN Inhibitor Approved for Treatment of Advanced Solid Tumors
Time of Update: 2022-04-17
Article source: Medical Cube InfoA few days ago, CDE's official website showed that the clinical trial (IND) application of Ascletis' second fatty acid synthase (FASN) inhibitor ASC60 was approved by the Food and Drug Administration for the treatment of advanced solid tumors .
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Using genetic scissors to specifically eliminate individual cell types
Time of Update: 2022-04-17
Researchers at the Karlsruhe Institute of Technology (KIT) in Germany have now developed this method to further eliminate the intact DNA of specific cell types, preventing them from forming during plant development .
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The culprit behind rising antibiotic resistance -- the overlooked jumping gene
Time of Update: 2022-04-17
So, what are the underlying forces driving this natural selection, the researchers ask?In the newly published paper, You and his postdoc Yao Yi suggest that this mysterious mechanism may be antibiotic-mediated selection for "jumping genes" (called transposons) that switch resistance genes from The chromosomes of the cells are carried to the plasmids .
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First detection and isolation of active SARS-CoV-2 in a hospital setting
Time of Update: 2022-04-17
This study strongly supports the aerosol transmission route of SARS COV-2 and urges revision of the infection control framework for COVID-19 to include airborne transmission .
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DNA discovery reveals key 'accordion effect' of genes shutting down
Time of Update: 2022-04-17
A research team led by Dr Andrew Kennery and Professor Marnie Breuett has discovered a new accordion-like triggering mechanism that is crucial to this process .
Professor Marnie Blewitt said the discovery of the accordion-like trigger took the team by surprise, changing their fundamental understanding of this crucial process so far .
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BRCA: 30 Years of Wind and Rain from Gene Identification to Targeted Therapy
Time of Update: 2022-04-17
The story of the classic tumor suppressor genes BRCA1 and BRCA2 began in 1990 when Mary-claire King's team at the University of California, Berkeley discovered that human chromosome 17q21 may be the location of the susceptibility gene for early-onset hereditary breast cancer Speaking of.
