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The trial included 32 patients with advanced metastatic colon cancer whose disease had progressed despite previous treatments for four cancers
The team observed that nine of 32 patients (28%) had stable disease or mixed responses by the end of the trial
"If we see this response with just one HIV drug, the next obvious trial is to see what else we can achieve with highly active antiretroviral therapy (HAART)," Ting added,
The first clues to this unusual drug trial were discovered in Ting's lab and his collaborators over the past decade
Repeating groups behave much like viruses rely on reverse transcription to replicate themselves and move around the genome
In their preclinical studies, Ting found that colorectal cancer cells were sensitive to lamivudine, reducing their ability to move
The study showed that the incidence of colon, breast and prostate cancers was significantly lower among U.
"We did this experiment to see if we could learn something new about cancer cell biology, and in the process found this unexpected, very encouraging result," Ting said
This work was supported by the National Institutes of Health, Cancer Research Gate, Fighting Cancer (SU2C), National Science Foundation, Burroughs Wellcome Trust, V Cancer Research Foundation, Affymetrix, Inc.
Journal Reference :
Mihir Rajurkar, Aparna R.
