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Guangzhou Health Institute has made progress in the research on the mechanism of chromatin advanced structure regulating cell fate

 Last Update: 2022-04-17
 Source: Internet
 Author: User

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Eukaryotic genomic DNA wraps around histone octamers to form chromatin, and folds step-by-step under the action of chromatin-architectural proteins to form long-distance chromatin interactions (or chromatin loops), topologically related domains, and chromatin Chromatin higher-order structures such as chromatin compartments

On April 5th, Beijing time, researcher Yao Hongjie's research group from Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences and Prof.

The researchers found that CTCF expression gradually increased during somatic cell reprogramming, and played a role in promoting the reprogramming of somatic cells into induced pluripotent stem cells

This study reveals that CTCF plays a co-regulatory role in mediating chromatin insulation and chromatin remodeling during the reprogramming of somatic cells into induced pluripotent stem cells

Researcher Yao Hongjie and Professor Fu Xiangdong are the co-corresponding authors of the article

Paper link

Schematic diagram of this study

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