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How to balance stable blood pressure lowering and brain function protection in the perioperative management of cerebrovascular disease?
Time of Update: 2023-02-03
Based on this, this issue of the "Urgent Threesome: Big Coffee Online" expert interview forum specially invited Professor Wang Chunlei of the First Affiliated Hospital of Harbin Medical University as the host of the conference, Professor Xu Shancai of the First Affiliated Hospital of Harbin Medical University and Professor Wen Zhifeng of the First Affiliated Hospital of China Medical University gathered in the cloud to discuss the perioperative blood pressure management strategies of patients with cerebrovascular diseases.
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Increased risk of dementia due to shift shifts? These 3 types have different performances!
Time of Update: 2023-02-03
Different types of frontotemporal dementia have different clinical manifestations, let's take a look!Frontotemporal lobe degeneration (FTLD) is a group of dementia syndromes characterized by progressive psychobehavioral abnormalities, executive dysfunction, and language impairment, and its pathology is characterized by selective progressive atrophy of the frontal and/or temporal lobes.
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Levodopa prodrug plus carbidopa prodrug significantly improves Parkinson's disease symptoms
Time of Update: 2023-02-03
Copyright InformationThis article was translated, written or commissioned by Jiahui Medical Research and Education Group (J-Med) in collaboration with the New England Journal of Medicine (NEJM) for NEJM Medical Frontiers.
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Studies of more than 60 million people have revealed that the greener the living environment, the lower the risk of dementia!
Time of Update: 2023-02-03
Recently, a study published in JAMA Network Open found that living in areas with a high proportion of parks and rivers seems to slow the risk of progression of neurological diseases, such as Alzheimer's disease and Parkinson's.
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Progress in the study of the mechanism of new circuits of anxiety-like behavior in mice
Time of Update: 2023-02-03
On December 3, 2022, Nature Communications published online the research group of Xu Xiaohong, a researcher at the Center for Excellence in Brain Science and Intelligent Technology (Institute of Neuroscience) and State Key Laboratory of Neuroscience, Chinese Academy of Sciences, entitled "A circuit from the ventral subiculum to anterior hypothalamic nucleus.
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Year-end inventory: GLP-1RA is used for progression of other diseases
Time of Update: 2023-02-03
Polycystic ovary syndrome GLP-1RA treatment can simultaneously address various comorbidities of PCOS, such as improving insulin sensitivity, reducing the risk of cardiovascular disease (CVD), and controlling weight.
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Expert comment: NBT Li Yulong's laboratory has developed a new oxytocin fluorescent probe to reveal the spatiotemporal dynamic regulation of neuropeptides
Time of Update: 2023-02-03
In summary, in this work, the authors developed a novel genetically encoded oxytocin fluorescent probe, which achieved high spatiotemporal resolution recording of extracellular oxytocin in vitro and in vivo, and reported the similarities and differences in the molecular mechanisms of oxytocin in the two release modes of neuronal axon terminals and somal dendrites, which provided a new reference for understanding the complexity of neuropeptide function.
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Neuron Ma Qiufu's team at Westlake University revealed the mechanism of transmitting visceral pain information
Time of Update: 2023-02-03
Importantly, under inflammatory and central desuppressive conditions, these neurons are dispensable for driving sensitized VMRs. Anatomically, a subset of VGLUT3 neurons projects to the parabrachial nucleus, whose photoactivation sufficiently produces aversion in mice with gastrointestinal inflammation without affecting VMRs. In summary, this study suggests the presence of different spinal cord substrates that transmit visceral sensory messages in pain and emotional dimensions.
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STTT Wang Wei's team from Huazhong University of Science and Technology proved that CAR-T cell therapy can safely and effectively treat relapsed or refractory neuromyelitis optica spectrum disorders
Time of Update: 2023-02-03
Original link: style="margin-right: auto;margin-left: auto;outline: 0px;width: 30px;display: inline-block;">—END—The content is [iNature]iNatureNeuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system (CNS) with a recurrent course and severe sequelae 。 The discovery of anti-aquaporin 4 (AQP4) autoantibodies has led to an understanding of its pathophysiology and precise targeting of plasma cells producing immunoglobulin G (IgG) that binds to AQP4 on the optic nerve and spinal cord, leading to a variety of pathological outcomes.
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Nature Review Series Annual Review: Three Breakthroughs in Gut-Brain Axis Cognition Released in 2022!
Time of Update: 2023-02-03
As a result, the journal Nature Reviews Gastroenterology & Hepatology published an annual review [1], focusing on three advances in the gut-brain axis published in 2022, involving neural pathways for thirst and satiety after drinking [2], and regulators of switching between eating and courtship behavior [3] and the relationship between enterovirome and cognitive function[4].
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ALS global new drug research and development pattern: AAV, Treg, stem cells and other therapies into the clinic
Time of Update: 2023-02-03
the FDA accepted Tofersen's new drug application and granted it priority review status◆ WAVELife Sciences：WVE-004◆ WAVELife Sciences：WVE-004WVE-004 is an ASO drug developed by WAVELife Sciences for ALS and frontotemporal dementia (FTD) caused by mutations in the C9orf72 gene, designed to selectively target transcriptional variants containing hexanucleotide repeat amplification (G4C2) associated with the C9orf72 gene, thereby preserving the C9orf72 protein.
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New drugs to treat Alzheimer's disease are here, approved by the FDA
Time of Update: 2023-02-03
Phase 3 clinical results were released recently,The future of lencanetumab can be expectedA Phase 3 randomized controlled trial study that confirms the clinical benefits of the drug as an inflammatory study was earlier published in the New England Journal of Medicine (NEJM) called Clarity AD.
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"Chinese Expert Recommendations for the Diagnosis and Treatment of Acute Cerebral Infarction under DRG/DIP Payment Method" released, deepening medical reform and benefiting the people!
Time of Update: 2023-02-03
The reform of medical insurance payment method is an important measure to deepen the reform of the medical system and medical security system, standardize the diagnosis and treatment behavior, reduce
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Molecular and spatial signatures of brain aging in Cell mice
Time of Update: 2023-02-03
The authors first used mononuclear RNA sequencing(snRNAseq)to characterize the single-cell transcription profiles of the frontal cortex and striatum in 1-month-old and 21-month-old mice, and performed spatially resolved single-cell transcriptome detection by MERFISH, which yielded 212 cell type markers and 204 aging-related genes Using the Harmony algorithm[1],[1],MERFISH and snRNA-seq data were co-embedded and comprehensively clustered to generate a total of 43 neuronal and non-neuronal cell types(Figure 1).
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The new coronavirus invades all the way along the nerves, explaining the eye discomfort and multi-organ symptoms after the impotence
Time of Update: 2023-02-03
Figure 1 Research results (Source: [1])01 The new coronavirus can target the eye as an infection, mainly attacking retinal ganglion cellsIn order to study whether the eye disease in K18-hACE2 mice is caused by the new coronavirus infection, the researchers used 104 PFU novel coronavirus (GISAID: EPI_ISL_407193) infects mice intranasally.
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Neuron: Yamei Tang's team at Sun Yat-sen University revealed brain damage caused by microglia to drive T cell infiltration-mediated radiotherapy
Time of Update: 2023-02-03
009The images in the article are from referencesClick on the blue word to follow usRadiation-induced brain injury (RIBI) is the most common complication of cranial radiation therapy in patients with head and neck cancer.
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Cell: Xiaowei Zhuang's team depicts molecular features and spatial organizational changes during brain aging
Time of Update: 2023-02-03
010 Open reprint, welcome to forward to Moments and WeChat groups Answering these questions is challenging because the brain's sheer cell count and molecular complexity hinder our comprehensive understanding of how the brain changes over its lifetime.
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The vomiting caused by food poisoning is the body protecting you, so what exactly does it do?
Time of Update: 2023-02-03
I believe that many people have experienced the impact of the first wave of the new crown epidemic this winter and are on the road from "yang" to "yin". Although the high fever has subsided, the cough
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The relationship between cardiovascular health and brain aging
Time of Update: 2023-02-03
The results adjusted for age, gender and education level are as follows:Good or moderate population CVH features are associated with slower progression of white matter hyperintensity (WMH) compared with poor overall CVH features.
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Refresh your awareness! Tau actually protects neurons in Alzheimer's patients
Time of Update: 2023-02-03
*For medical professionals onlyNeurofibrillary tangles caused by excessive phosphorylation of tau protein are one of the two main pathological features of Alzheimer's disease (AD), so excessive tau pr
