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Fang Fei/Lu Jiahong's team reports artificial intelligence helps Alzheimer's disease drug discovery
Time of Update: 2022-01-26
In order to solve this challenge, on January 6, 2022, the team of associate professor Fang Fei of the University of Oslo in Norway and the team of Lu Jiahong, associate professor of the Chinese Medical Research Institute of the University of Macau published online in the journal Nature Biomedical Engineering entitled Amelioration of Alzheimer's disease pathology by mitophagy inducers identified Long research paper on via machine learning and a cross-species workflow .
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Can't control what you eat?
Time of Update: 2022-01-26
Authors: Richard Simerly & Ralph DiLeone Artificial activation of neurons in the cerebellar region reduces food intake in mice .
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How to diagnose and treat Parkinson's disease depression, see the latest expert consensus!
Time of Update: 2022-01-26
Long-term depression can aggravate the motor symptoms of Parkinson's disease, form a vicious circle, seriously affect the quality of life of patients, and increase the family and socioeconomic burden .
2. Severe depression: The recommended drugs for the treatment of depression in Parkinson's disease are mainly pramipexole and venlafaxine .
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STTT major progress!
Time of Update: 2022-01-26
iNature revascularization and angiogenesis, as substrates of persistent collateral circulation, play a critical role in determining the severity and clinical outcome of acute ischemic stroke (AIS) caused by large vessel occlusion (LVO) .
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Challenging rare genetic diseases!
Time of Update: 2022-01-26
January 7, 2022 / eMedClub News / -- Recently, Biogen received an exclusive license from Ionis Pharmaceuticals to develop and commercialize antisense oligonucleotide (ASO) drug BIIB115 .
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Multi-picture knowledge | This disease easily confused with cervical spondylosis is related to posterior cerebral artery stroke
Time of Update: 2022-01-26
A case report in BMC Neurology of a posterior cerebral artery stroke associated with thoracic outlet syndrome (TOS) suggests that extra caution should be exercised with any of the common symptoms, regardless of whether the patient is elderly or young Everyone should "get to the bottom of their medical history", and sometimes one more question "opens up a new world" .
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The patient will bleed after taking this medicine, and may suffer a stroke if he does not take it. How would you choose?
Time of Update: 2022-01-26
Chapter 21: Traditional Chinese Medicine Treats Cardiovascular and Cerebrovascular Diseases and Dizziness One day, Zhang Xiang began to complain after returning home: A 60-year-old Aunt Dong has no previous cerebral infarction, myocardial infarction, angina pectoris or transient ischemic attack He started taking clopidogrel just because atherosclerosis was found in cranial CTA and coronary CTA .
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CNS chronic long-term COVID syndrome: a persistent COVID-19 disease with neurological deficits
Time of Update: 2022-01-26
This article discusses possible causative factors such as viral load loci, differences in immune response, neurodegenerative changes, and inflammation to understand and study the pathogenesis of long-term COVID neurological syndrome .
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【Nature Sub-Journal】Can the human microglia atlas guide brain disease research?
Time of Update: 2022-01-26
The researchers analyzed thousands of microglia in different brain regions in patients who had been diagnosed with various psychiatric disorders and deceased patients with neurodegenerative diseases .
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J Neurosci︱Merlin Lab Reveals Signaling Pathway Necessary for Spike Ripple and Spatial Working Memory: NRG1/ErbB4
Time of Update: 2022-01-26
, J Neurosci,, 2021) In order to study the effect of ErbB4 kinase activity on spike ripples in vivo Influence, the authors injected 1NMPP1 into the abdominal cavity of T796G mice and found that the frequency of sharp wave ripples was significantly increased (Fig.
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Nature sub-journal: Targeting mitophagy to clear brain "garbage" to treat Alzheimer's disease
Time of Update: 2022-01-26
Interestingly, these mitophagy-inducing agents can effectively improve neuronal function, reduce Alzheimer's disease-related pathological changes, and enhance learning and memory in animal models .
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Courier's $450 million to help develop nucleic acid therapy targeting the nervous system, Lilly acquires innovative delivery technology
Time of Update: 2022-01-26
▎WuXi AppTec Content Team Editor On January 6, 2022, Eli Lilly and Company announced that it has acquired the exclusive rights to Entos Pharmaceuticals' proprietary Fusogenix nucleic acid delivery technology platform to develop and commercialize drugs targeting the central and peripheral nervous systems.
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Promote brain health and reduce dementia risk by 28%!
Time of Update: 2022-01-26
Image source: 123RF Several studies have now found that physical activity promotes brain health and reduces the risk of cognitive decline and dementia in a number of ways .
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The clinical characteristics of MRI of acute cerebral infarction are full of dry goods!
Time of Update: 2022-01-26
From August 5th to 6th, 2021, at the "2nd Huashan International Forum on Cognitive and Brain Diseases and the 15th China Neurology Forum", Professor He Zhiyi from the Department of Neurology of the First Affiliated Hospital of China Medical University gave us a speech He shared a wonderful lecture on the theme of "clinical characteristics of acute cerebral infarction head MRI" .
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Inventory: Blockbuster achievements in the field of Alzheimer's disease research in 2021!
Time of Update: 2022-01-26
Content Source | Bio Valley Alzheimer's disease (AD) is the most common, irreversible and progressive form of dementia . According to the World Alzheimer's Disease Report 2018, every 3 seconds, one
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I have done a lot of inspections, but the cause of the headache is still unknown. How can the experts find out?
Time of Update: 2022-01-26
According to the patient's medical history, physical signs, head CT, cerebral hemorrhage, post-traumatic headache, angle-closure glaucoma, hydrocephalus, intracranial tumor, drug-induced headache Headaches are not currently supported, and those marked in bold need to be considered .
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Summary of good clinical basics of neurology in 2021｜Year-end inventory
Time of Update: 2022-01-26
➤Unexplained embolic stroke ≠ cryptogenic stroke, this "new" cause should be considered ➤This article helps you avoid misdiagnosis of stroke in the emergency room ➤Summary of knowledge points: pathophysiology, etiology, clinical manifestations and evaluation of different types of stroke Epilepsy Epilepsy is one of the most common diseases in neurology .
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Are we treating Alzheimer's the wrong way?
Time of Update: 2022-01-26
▲ Hippocampal samples from patients with different rates of disease progression (Image source: Reference [2]) In vitro, researchers tried to culture tau protein samples in different samples, and those with misfolding were significantly faster.
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If you eat too much sugar as a child, your memory will worsen when you grow up, the latest research in Nature
Time of Update: 2022-01-26
The second experiment is the NOR (Novel Object Recognition) experiment, which measures the basic cognitive and memory functions that are not related to the hippocampus and are controlled by the cerebral cortex by comparing the time it takes mice to explore new things that are not related to the environment .
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Neuron: Love and hate!
Time of Update: 2022-01-26
In order to further confirm whether the α and β cell populations in the VMHvl brain region are involved in the reproductive state-dependent social behavior of female mice, the researchers used fiber-optic calcium imaging technology to dynamically observe these two types of neurons in the virgin phase, lactating phase, and post-lactation phase for a long time.
