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Fengse comes from the qubit report of Concave Temple | The public account QbitAI often feels that its memory is worse than others? Is it possible that you ate too much sugar as a child? Scientists from the University of Georgia and the University of Southern California have found for the first time that eating too much sugar in childhood, when the brain is rapidly developing, can impair memory function in adulthood
.
△ What happened to the research results published in the Nature sub-journal? Are the hazards of tooth decay and obesity alone not enough? How did you come to this conclusion? Scientists first divided 21 juvenile male rats aged 26-28 days into an experimental group and a control group, and fed them free access to monosaccharide solution and ordinary filtered water under the same food
.
The monosaccharide solution has a mass-to-volume ratio of 11%, 65% of fructose and 35% of glucose, and the ratio simulates the sugar-sweetened beverages that humans often drink
.
The mice were monitored for food intake, solution intake and body weight three times a week
.
When the mice became adults, that is, 60 days old, the memory task experiments were started
.
The first experiment was the NOIC (Novel Object in Context) experiment, which measures the hippocampus-dependent episodic memory function based on the ability of mice to recognize familiar objects in a specific environment
.
Specifically, it provides two different environments: a translucent box and a gray opaque box
.
On the first day, two different objects A and B were placed in a translucent box, and the mice were put into familiarity; on the second day, the mice were placed in a gray box, and B was replaced by A, that is, two identical objects were placed A; On the third day, change the objects in the gray box back to A and B.
The mice have seen both objects, but at this time, the placement of one of the objects has never been seen before for the mice.
.
The time the mice spent exploring the "new" object was then recorded divided by the sum of the time spent exploring objects A and B, known as the "discrimination index" (assuming that the mice would spend more time on unfamiliar objects)
.
Recognition and exploration are defined as: sniffing with the nose or touching objects with the front paws
.
The second experiment is the NOR (Novel Object Recognition) experiment, which measures the basic cognitive and memory functions that are not related to the hippocampus and are controlled by the cerebral cortex by comparing the time it takes mice to explore new things that are not related to the environment
.
Specifically, put the mice in a space and give two identical jars for the mice to explore; then fully clean and disinfect the space, replace one of the objects, and then put the mice in to record their exploration of the two jars time
.
As a result, the performance of the two groups of mice in the NOR experiment was not much different, but the results of the NOIC experiment were different: compared with the mice that drank plain water when they were young, the mice that drank too much sugar water were exploring familiarity.
The time spent on object B is longer, that is, the memory capacity for it becomes weaker
.
△ CTL stands for white water, and SUG stands for sugar water.
This means that high sugar intake in early life development has no effect on the memory function dependent on the cerebral cortex, but it will damage the contextual and episodic memory function dependent on the hippocampus
.
Among them, RNA sequencing of mouse hippocampus showed that high-glucose diet mainly affects four pathways related to neurotransmitter prominent signaling: dopaminergic, glutamatergic, cholinergic and serotonergic signaling pathways
.
The mechanism is hard to find, why is the intestinal flora like this? As the so-called "indecision, quantum mechanics; the mechanism is hard to find, the intestinal flora" - scientists extracted the feces of mice and began to find answers from their intestinal flora
.
It turns out that sugar-sweetened beverages really have an impact on the gut microbiota: Two Parabacteroides species in the gut of mice raised on sugar water are inversely associated with hippocampal function: Parabacteroides dillide and Parabacteroides johnsonii The concentration of Bacteroides increased
.
The higher the concentration of these two bacteria, the stronger the damage to the hippocampus
.
In addition, considering the impact of high sugar intake on body weight, scientists have also done some experiments
.
The results were somewhat unexpected.
Excessive sugar intake during "adolescence" in mice had no effect on adult body weight
.
However, they have reduced glucose tolerance (the effect is that they are prone to diabetes)
.
Hey, although sugar can make people happy, it seems that it is better to touch less since childhood
.
Original paper: https:// Reference link: https://news.
uga.
edu/sugar-not-so-nice-childs-brain-development/— End - qubit recruitment qubit QbitAI վ'ᴗ' ի Track new trends in AI technology and products, click "Good-looking" if you like it!
.
△ What happened to the research results published in the Nature sub-journal? Are the hazards of tooth decay and obesity alone not enough? How did you come to this conclusion? Scientists first divided 21 juvenile male rats aged 26-28 days into an experimental group and a control group, and fed them free access to monosaccharide solution and ordinary filtered water under the same food
.
The monosaccharide solution has a mass-to-volume ratio of 11%, 65% of fructose and 35% of glucose, and the ratio simulates the sugar-sweetened beverages that humans often drink
.
The mice were monitored for food intake, solution intake and body weight three times a week
.
When the mice became adults, that is, 60 days old, the memory task experiments were started
.
The first experiment was the NOIC (Novel Object in Context) experiment, which measures the hippocampus-dependent episodic memory function based on the ability of mice to recognize familiar objects in a specific environment
.
Specifically, it provides two different environments: a translucent box and a gray opaque box
.
On the first day, two different objects A and B were placed in a translucent box, and the mice were put into familiarity; on the second day, the mice were placed in a gray box, and B was replaced by A, that is, two identical objects were placed A; On the third day, change the objects in the gray box back to A and B.
The mice have seen both objects, but at this time, the placement of one of the objects has never been seen before for the mice.
.
The time the mice spent exploring the "new" object was then recorded divided by the sum of the time spent exploring objects A and B, known as the "discrimination index" (assuming that the mice would spend more time on unfamiliar objects)
.
Recognition and exploration are defined as: sniffing with the nose or touching objects with the front paws
.
The second experiment is the NOR (Novel Object Recognition) experiment, which measures the basic cognitive and memory functions that are not related to the hippocampus and are controlled by the cerebral cortex by comparing the time it takes mice to explore new things that are not related to the environment
.
Specifically, put the mice in a space and give two identical jars for the mice to explore; then fully clean and disinfect the space, replace one of the objects, and then put the mice in to record their exploration of the two jars time
.
As a result, the performance of the two groups of mice in the NOR experiment was not much different, but the results of the NOIC experiment were different: compared with the mice that drank plain water when they were young, the mice that drank too much sugar water were exploring familiarity.
The time spent on object B is longer, that is, the memory capacity for it becomes weaker
.
△ CTL stands for white water, and SUG stands for sugar water.
This means that high sugar intake in early life development has no effect on the memory function dependent on the cerebral cortex, but it will damage the contextual and episodic memory function dependent on the hippocampus
.
Among them, RNA sequencing of mouse hippocampus showed that high-glucose diet mainly affects four pathways related to neurotransmitter prominent signaling: dopaminergic, glutamatergic, cholinergic and serotonergic signaling pathways
.
The mechanism is hard to find, why is the intestinal flora like this? As the so-called "indecision, quantum mechanics; the mechanism is hard to find, the intestinal flora" - scientists extracted the feces of mice and began to find answers from their intestinal flora
.
It turns out that sugar-sweetened beverages really have an impact on the gut microbiota: Two Parabacteroides species in the gut of mice raised on sugar water are inversely associated with hippocampal function: Parabacteroides dillide and Parabacteroides johnsonii The concentration of Bacteroides increased
.
The higher the concentration of these two bacteria, the stronger the damage to the hippocampus
.
In addition, considering the impact of high sugar intake on body weight, scientists have also done some experiments
.
The results were somewhat unexpected.
Excessive sugar intake during "adolescence" in mice had no effect on adult body weight
.
However, they have reduced glucose tolerance (the effect is that they are prone to diabetes)
.
Hey, although sugar can make people happy, it seems that it is better to touch less since childhood
.
Original paper: https:// Reference link: https://news.
uga.
edu/sugar-not-so-nice-childs-brain-development/— End - qubit recruitment qubit QbitAI վ'ᴗ' ի Track new trends in AI technology and products, click "Good-looking" if you like it!
