-
How to stop medication for epilepsy patients?
Time of Update: 2022-01-26
Recommendation Statement 1a: In adults with epilepsy who have been seizure-free for at least 2 years, clinicians, patients, and caregivers should discuss the risks and benefits of discontinuing antiepileptic drugs.
-
Abnormal MRI after a seizure, what do you think?
Time of Update: 2022-01-26
Table 3 Abnormal imaging changes of local and distant sites caused by epileptic seizures Abnormal signals on MRI of the right thalamus and hippocampus in patients with status epilepticus T2 hyperintensity involving the hippocampus and extending to the right thalamus with limited diffusion and no enhancement of the lesion may be associated with status epilepticus (Katramados AM, et al.
-
The first batch of express in 2022, FDA today approves innovative insomnia therapy
Time of Update: 2022-01-26
S. FDA has approved Quviviq (daridorexant) for the treatment of adult patients with insomnia .
” Reference: [1] Idorsia receives US FDA approval of Quviviq (daridorexant) 25 and 50 mg for the treatment of adults with insomnia.
-
Drug Development The first domestically produced Teriflunomide debuts!
Time of Update: 2022-01-26
Teriflunomide's original research drug (trade name: Aubagio) was developed by Sanofi and was approved for marketing in China in July 2018 for the treatment of relapsing MS .
-
EHJ: Can Anger and Upset Trigger Stroke?
Time of Update: 2022-01-26
Although previous studies have identified psychological stress [2-3], life events [4], alcohol abuse, clinical infections, coffee consumption, sexual behavior, trauma, and surgery as potential triggers for stroke [5-7], few reports have been made The correlation between emotions such as anger or upset or severe physical exertion and stroke, and the sample size of the above-mentioned studies is usually small and limited to a certain country or region [8] .
-
How has the outcome of cerebrovascular disease changed in 20 years?
Time of Update: 2022-01-26
Professor Kazunori Toyoda's team from the Department of Cerebrovascular Medicine, National Cardiovascular and Cerebrovascular Center, Japan, recently used the Japanese Stroke Database to investigate long-term changes in initial neurological severity and short-term functional outcomes in ischemic and hemorrhagic stroke patients over a 20-year period with a large population.
-
Master these 3 forms, acute migraine diagnosis is no longer "headache"
Time of Update: 2022-01-26
At present, the diagnostic criteria for migraine have been relatively complete, and some memory skills can also help to make an accurate diagnosis .
For example, it would be more helpful to support the diagnosis if the patient brought along his/her headache diary, or a questionnaire with detailed migraine-related information .
-
Vision linked to dementia?
Time of Update: 2022-01-26
A recent study published in JAMA Internal Medicine found that having cataract surgery was associated with a nearly 30 percent lower risk of dementia .
After adjustment for years of education, smoking history, and stratification by APOE e genotype (a gene associated with Alzheimer's disease risk), sex, and age at cataract diagnosis .
-
Autophagy︱Li Xiaojiang's team discovered new progress in the clearance of TDP-43 cytoplasmic aggregation by SQSTM1 in a non-human primate model
Time of Update: 2022-01-26
Written by ︱ Yin Peng editor ︱ Sizhen Wang Neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and Alzheimer's disease are caused by mista
-
Headache as soon as menstruation comes, it may be caused by it (with solutions included)
Time of Update: 2022-01-26
Image source: What are the common manifestations of estrogen-related migraine headaches?
1. In the acute attack stage of this disease, it is usually a "headache to treat the head", that is, analgesic treatment is given .
-
Neuron: Neurotransmitter "generously" transmits itch information
Time of Update: 2022-01-26
In situ hybridization experiments found that MrgprA3-positive neurons in the DRG region were enriched to express type 2 vesicular glutamate transporter (Vglut2) and neuromedin B (NMB, Figure 1).
-
Neuron observational learning promotes long-range replay of hippocampal place cells pointing to future reward locations during wakefulness
Time of Update: 2022-01-26
The authors recorded the activity of place cells in the CA1 region of the hippocampus of the observed rat in this task, trying to understand whether the activation sequence of place cells in the observed rat's own movement in the T-shaped maze was replayed in the observation box, and if so, the replayed sequence.
-
Alzheimers Dement︱Jinjing Yao et al found a new therapeutic target for Alzheimer's disease: increased neuronal excitability mediated by type 2 nilanine receptor activity
Time of Update: 2022-01-25
Preliminary work in the laboratory of Professor Wayne Chen, University of Calgary, Canada, showed that shortening the open time of RyR2 can prevent and treat AD-related neuronal damage and cognitive decline in AD mouse models (5xFAD+/-).
-
【Mind Map】A picture will show you how to prevent acute stroke during surgery
Time of Update: 2022-01-25
Intraoperative beta-blocker use increases perioperative stroke risk in patients undergoing noncardiac surgery with intraoperative metoprolol.
Intraoperative bleeding and blood transfusion therapy Intraoperative bleeding and anemia are associated with an increased risk of postoperative stroke, especially in cardiac surgery patients .
-
Learn how to use "common neuropathic pain" in one article
Time of Update: 2022-01-25
Welcome to leave a message and share in the comment area~ References: [1] Chinese expert consensus on the diagnosis and treatment of peripheral neuropathic pain [J].
-
Nat Neurosci︱ Jingjing Liu et al reveal the regulatory effect of hypothalamic melanin-clustering hormone on the activity of the hippocampal-dorsolateral septal circuit
Time of Update: 2022-01-25
The effect of MCH on the high-frequency firing of dLS neurons The previous experiments explained the slow effect The effect of MCH on GABA- and glutamate-mediated rapid synaptic transmission, the authors next investigated the role of this regulatory effect on information transmission at the overall circuit level .
-
Is positional vertigo necessarily "otolithiasis"?
Time of Update: 2022-01-25
Therefore, after asking the medical history and finding a history of headache, he was diagnosed as "vestibular migraine", and preventive treatment was given, but the effect was still not good .
Therefore, when a patient experiences dizziness induced by a change in position, it may be vestibular migraine or otolithiasis .
-
Lancet Neurol Annual Review: 2021 Neurology Summary of Alzheimer's Disease
Time of Update: 2022-01-25
At 76 weeks, donanemab reduced brain amyloid beta and resulted in a better composite score of cognition and increased ability to perform activities of daily living compared with the placebo group .
-
From "poison" to "drug" in science: the biological basis of cannabinoid medicinal use
Time of Update: 2022-01-25
Regarding medicinal value, cannabinoid-related research is applied to the treatment of epilepsy [4], phytocannabinoids can inhibit neuronal excitability in mouse and human epileptic foci, and can be used to rescue neurons from oxidation by means such as CBD Injury and mitochondrial dysfunction may partly support a reduction in seizure frequency in clinical trials .
-
Parents are weak, be careful!
Time of Update: 2022-01-25
Recently, two new large-scale cohort studies have shown that frailty is significantly associated with a 520% increased risk of cardiovascular disease (CVD) death in the elderly [2] and a 268% increased risk of dementia [3] .
