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▎WuXi AppTec content team editors Dementia affects nearly 50 million people around the world, and there is currently no therapy that can effectively change the course of the disease
.
Research suggests that visual impairment may be an important risk factor for dementia, and that cataracts affect most older adults at risk for dementia
.
Cataracts are the leading cause of blindness worldwide, affecting more than 35 million people worldwide and causing approximately 20 million blindness
.
Visual function is so important to older adults, will vision-preserving interventions, such as cataract surgery, alter the risk of dementia? A recent study published in JAMA Internal Medicine found that having cataract surgery was associated with a nearly 30 percent lower risk of dementia
.
Screenshot source: JAMA Internal Medicine The observational study included 3,038 participants, with a mean age of 74.
4 years, who were diagnosed with cataract or glaucoma but did not have dementia
.
The investigators followed up every 2 years until the patient developed dementia
.
The researchers assessed the cognitive abilities of the participants based on a cognitive ability screening on a scale of 0-100
.
Participants with scores below 85 underwent further neurological testing
.
The primary outcome was the occurrence of dementia as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition
.
After an average follow-up of 7.
8 years, 853 participants developed dementia, 709 of whom had Alzheimer's disease, and about half of the participants (45%) underwent cataract surgery
.
After adjustment for years of education, smoking history, and stratification by APOE e genotype (a gene associated with Alzheimer's disease risk), sex, and age at cataract diagnosis
.
The researchers found that participants who had surgery on either eye had an approximately 30% lower risk of developing dementia from any cause for at least 10 years after surgery compared to participants who did not undergo cataract surgery (RR=0.
71, P<0.
001)
.
The researchers found similar results after adjusting for multiple potential confounders, such as eye surgery within two years before dementia diagnosis
.
And cataract surgery has also been linked to a reduced risk of Alzheimer's disease
.
But compared with cataract surgery, having glaucoma surgery (which does not restore vision) was not significantly associated with the risk of developing dementia
.
In addition, the researchers found that the only factor that was more protective than cataract surgery was not having APOE e4 allele (high risk gene for Alzheimer's disease)
.
Image credit: 123RF The study's lead author, Cecilia Slee, PhD, associate professor of ophthalmology at the University of Washington School of Medicine, said: "After adjusting for some confounding factors, the study still found a strong association between cataract surgery and dementia risk.
Association
.
" The researchers analyzed the mechanism by which cataract surgery is associated with a reduced risk of dementia
.
First, after cataract surgery, people may receive higher-quality sensory input, which may be beneficial in reducing the risk of dementia
.
Second, cataract surgery can reactivate blue light-sensing cells, and while people get more blue light, it may also help regulate sleep cycles and cognitive function
.
Finally, visual impairment may lead to psychosocial difficulties, withdrawal from social interactions, and reduced activity or exercise, all of which may be associated with cognitive decline
.
The team said the study also had limitations, such as only evaluating participants' first cataract surgery, so it's uncertain whether subsequent surgeries affected dementia risk
.
"The findings suggest that cataract surgery is significantly associated with a lower risk of dementia in adults ≥65 years of age," the paper concluded
.
The results have important implications for the care of older adults and, to a large extent, may improve the quality of life for individuals and their families
.
The results also provide strong evidence, insights and potential treatments to slow or prevent age-related dementia for further research into the association of dementia with other retinal diseases such as age-related macular degeneration
.
Related reading Change these 12 points as soon as possible, 40% of dementia can be prevented! The "Lancet" report recommends comprehensive prevention and control of the "Lancet" sub-issue of the Chinese Center for Disease Control and Prevention: More and more Chinese people are losing sight, and these reasons should be paid attention to! How to deal with the "number one killer" of national health? The latest call from the World Stroke Organization: Preventing stroke is also preventing dementia! 12-year follow-up study: How harmful is poor blood sugar control? Linked to 3x the Risk of Dementia! "The Lancet": Dementia patients are mania, anxiety, commonly used drugs are ineffective, and may be harmful Reference [1] Lee, CS, et al.
(2021).
Association Between Cataract Extraction and Development of Dementia.
JAMA Internal Medicine , DOI: 10.
1001/jamainternmed.
2021.
6990[2] Study: Cataract surgery linked with lessened dementia risk.
Retrieved 6-DEC-2021, FROM https:// Disclaimer: WuXi AppTec The content team focuses on introducing global biomedical health research progress
.
This article is for information exchange purposes only, and the views expressed in this article do not represent WuXi AppTec's position, nor do they represent WuXi AppTec's support or opposition to the views expressed in this article
.
This article is also not a treatment plan recommendation
.
For guidance on treatment options, please visit a regular hospital
.
.
Research suggests that visual impairment may be an important risk factor for dementia, and that cataracts affect most older adults at risk for dementia
.
Cataracts are the leading cause of blindness worldwide, affecting more than 35 million people worldwide and causing approximately 20 million blindness
.
Visual function is so important to older adults, will vision-preserving interventions, such as cataract surgery, alter the risk of dementia? A recent study published in JAMA Internal Medicine found that having cataract surgery was associated with a nearly 30 percent lower risk of dementia
.
Screenshot source: JAMA Internal Medicine The observational study included 3,038 participants, with a mean age of 74.
4 years, who were diagnosed with cataract or glaucoma but did not have dementia
.
The investigators followed up every 2 years until the patient developed dementia
.
The researchers assessed the cognitive abilities of the participants based on a cognitive ability screening on a scale of 0-100
.
Participants with scores below 85 underwent further neurological testing
.
The primary outcome was the occurrence of dementia as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition
.
After an average follow-up of 7.
8 years, 853 participants developed dementia, 709 of whom had Alzheimer's disease, and about half of the participants (45%) underwent cataract surgery
.
After adjustment for years of education, smoking history, and stratification by APOE e genotype (a gene associated with Alzheimer's disease risk), sex, and age at cataract diagnosis
.
The researchers found that participants who had surgery on either eye had an approximately 30% lower risk of developing dementia from any cause for at least 10 years after surgery compared to participants who did not undergo cataract surgery (RR=0.
71, P<0.
001)
.
The researchers found similar results after adjusting for multiple potential confounders, such as eye surgery within two years before dementia diagnosis
.
And cataract surgery has also been linked to a reduced risk of Alzheimer's disease
.
But compared with cataract surgery, having glaucoma surgery (which does not restore vision) was not significantly associated with the risk of developing dementia
.
In addition, the researchers found that the only factor that was more protective than cataract surgery was not having APOE e4 allele (high risk gene for Alzheimer's disease)
.
Image credit: 123RF The study's lead author, Cecilia Slee, PhD, associate professor of ophthalmology at the University of Washington School of Medicine, said: "After adjusting for some confounding factors, the study still found a strong association between cataract surgery and dementia risk.
Association
.
" The researchers analyzed the mechanism by which cataract surgery is associated with a reduced risk of dementia
.
First, after cataract surgery, people may receive higher-quality sensory input, which may be beneficial in reducing the risk of dementia
.
Second, cataract surgery can reactivate blue light-sensing cells, and while people get more blue light, it may also help regulate sleep cycles and cognitive function
.
Finally, visual impairment may lead to psychosocial difficulties, withdrawal from social interactions, and reduced activity or exercise, all of which may be associated with cognitive decline
.
The team said the study also had limitations, such as only evaluating participants' first cataract surgery, so it's uncertain whether subsequent surgeries affected dementia risk
.
"The findings suggest that cataract surgery is significantly associated with a lower risk of dementia in adults ≥65 years of age," the paper concluded
.
The results have important implications for the care of older adults and, to a large extent, may improve the quality of life for individuals and their families
.
The results also provide strong evidence, insights and potential treatments to slow or prevent age-related dementia for further research into the association of dementia with other retinal diseases such as age-related macular degeneration
.
Related reading Change these 12 points as soon as possible, 40% of dementia can be prevented! The "Lancet" report recommends comprehensive prevention and control of the "Lancet" sub-issue of the Chinese Center for Disease Control and Prevention: More and more Chinese people are losing sight, and these reasons should be paid attention to! How to deal with the "number one killer" of national health? The latest call from the World Stroke Organization: Preventing stroke is also preventing dementia! 12-year follow-up study: How harmful is poor blood sugar control? Linked to 3x the Risk of Dementia! "The Lancet": Dementia patients are mania, anxiety, commonly used drugs are ineffective, and may be harmful Reference [1] Lee, CS, et al.
(2021).
Association Between Cataract Extraction and Development of Dementia.
JAMA Internal Medicine , DOI: 10.
1001/jamainternmed.
2021.
6990[2] Study: Cataract surgery linked with lessened dementia risk.
Retrieved 6-DEC-2021, FROM https:// Disclaimer: WuXi AppTec The content team focuses on introducing global biomedical health research progress
.
This article is for information exchange purposes only, and the views expressed in this article do not represent WuXi AppTec's position, nor do they represent WuXi AppTec's support or opposition to the views expressed in this article
.
This article is also not a treatment plan recommendation
.
For guidance on treatment options, please visit a regular hospital
.
