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The evolution of neuroprotective agents: a picture to understand the past, present and future of neuroprotective agents
Time of Update: 2022-01-25
*Read only for medical professionals Reference neuroprotective agent's journey of discovery, with ups and downs and twists and turns . *This article is only used to provide scientific information t
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How to infer the responsible blood vessel from the cerebral infarction site?
Time of Update: 2022-01-25
The content of this issue of "Doctor Station Learning Week - Cerebral Infarction Special Session" is divided into basic and advanced versions.
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Science: Technological innovation!
Time of Update: 2022-01-25
Chen of Boston University combined two-photon calcium imaging technology and multiple rounds of in situ hybridization experiments to form CRACK technology, which realized the analysis of the correlation between multiple cell subtypes and behavioral functions .
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Nearly $1 billion!
Time of Update: 2022-01-25
January 13, 2022 / eMedClub News / -- Acadia Pharmaceuticals and Stoke Therapeutics recently announced that the two companies have entered into a nearly $1 billion collaboration to jointly discover, develop and commercialize novel RNA-based medicines, For the treatment of severe and rare inherited neurodevelopmental disorders of the central nervous system (CNS) .
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Updated after 25 years, the American Academy of Neurology issued 14 recommendations for discontinuing antiepileptic drugs in epilepsy patients without seizures
Time of Update: 2022-01-25
Recommendation 2: Clinicians may discuss that the risk of seizure recurrence after ASM discontinuation in patients who have undergone epilepsy surgery and are seizure-free is uncertain due to lack of evidence (Grade C) .
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Sciatica: Immediate Surgery or Watchful Waiting?
Time of Update: 2022-01-25
Leg pain was significantly less in the discectomy group than in the conservative treatment group at 1 year (mean difference, 2.
Commentary In patients with disc-related sciatica who have been ill for several months to 1 year, microscopic lumbar discectomy initially reduces pain compared with conservative management .
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Could this disease increase the risk of dementia?
Time of Update: 2022-01-25
73m2) was assessed using logistic regression, and post-event dementia and CKD were assessed using Cox and competing risk regression models The associations were adjusted for age, sex, education, stroke severity, prior stroke history, white matter disease, diabetes, and language impairment .
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Neuron︱“Eros and Anger”: The Neural Matrix of Female Social Behavior Accompanied by Changes in Physiological Status
Time of Update: 2022-01-25
Figure 2 Activation of alpha neurons increases female sexual receptivity and inhibits aggressive behavior (Source: Liu M.
Aggression-related beta neurons show a lactation-dependent response to social object information The authors further explored female Social behavior in different lactation states depends on which neuronal activity changes .
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Studying more than 400 human brains, scientists find new evidence that exercise benefits brain health
Time of Update: 2022-01-25
On January 7, 2022, Kaitlin Casaletto's team published a research paper titled: Late-life physical activity relates to brain tissue synaptic integrity markers in older adults in the journal Alzheimer's & Dementia.
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JAMA Neurol cover Miao Zhongrong/Yu Wengui found that drug-eluting stents are more effective in preventing in-stent restenosis in patients with intracranial atherosclerotic stenosis
Time of Update: 2022-01-25
iNature in-stent restenosis (ISR) is the leading cause of stroke recurrence after intracranial stenting in patients treated with standard bare metal stents (BMS) .
In conclusion, the The study found that DESs reduced the risk of ISR and ischemic stroke recurrence in patients with symptomatic high-grade ICAS compared with BMS .
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Are women more likely to drink alcohol?
Time of Update: 2022-01-24
Source: Nature Communications Comparing sex differences showed that reducing the strength of PVT projections significantly increased alcoholism in female mice, but had no effect in male mice .
Source: Nature Communications In summary: Researchers have discovered a PVT-BNST-CRF circuit associated with alcoholism in mice, which has obvious gender dimorphism .
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Over $1 billion!
Time of Update: 2022-01-24
Using ABL Bio's proprietary Grabody-B platform technology, ABL301 can effectively cross the blood-brain barrier (BBB) and is a potential "first-in-class" bispecific antibody in preclinical stage targeting α-synapses Nuclear protein (α-syn) and insulin-like growth factor 1 receptor (IGF1R) for the treatment of Parkinson's disease (PD) and other potential indications .
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How do gut microbes affect the brain?
Time of Update: 2022-01-24
The injected alpha-synuclein itself appears to remain in the gut, but Johns Hopkins neuroscientist and study co-author Valina Dawson believes there may be a domino effect: Misfolded proteins pass errors to The vagus nerve, until the protein in the brain eventually misfolds .
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Why can't I quit milk tea?
Time of Update: 2022-01-24
The study shows that taste buds often have difficulty distinguishing the difference between real sugar and artificial sweeteners, but gut cells can easily identify it and relay the difference to the brain within milliseconds .
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Nature Neuroscience: Gut optogenetics uncovers the neurobiological mechanism of gut preference for sucrose
Time of Update: 2022-01-24
CCK-positive Neuropod cells form glutamatergic synapses with vagal nodose neurons to rapidly transmit sensory signals from the duodenum to the brain .
After photoinhibition of CCK-positive Neuropod cells in duodenal epithelial cells, perfusion of sucrose and sweeteners did not induce the firing activity of vagus nerve .
[Reference] 1 https://doi.
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Molecular Cancer Li Gang/Xue Hao of Shandong University discover new potential therapeutic targets for glioma
Time of Update: 2022-01-24
Finally, circNEIL3 was packaged into exosomes by hnRNPA2B1 and delivered to infiltrating tumor-associated macrophages (TAMs), enabling them to acquire immunosuppressive properties by stabilizing IGF2BP3, thereby promoting glioma progression .
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Stroke: Association of female infertility, miscarriage, stillbirth and stroke risk
Time of Update: 2022-01-24
As of September 26, 2020, we conducted a comprehensive literature search of cohort and case-control studies investigating the association between infertility, miscarriage, stillbirth, and stroke .
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Don't miss it!
Time of Update: 2022-01-24
02 Direct transport to the cath lab improves functional outcomes▌ ANGIOCAT study A single-center, randomized, controlled, blinded outcome-assessing clinical study published in JAMA Neurol, the primary efficacy endpoint was shift analysis of 90-day mRS score (improvement of 1 point or more probabilities) .
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A quadrivalent meningococcal conjugate vaccine has been approved for marketing, and it can be used under the age of 2!
Time of Update: 2022-01-24
Screenshot source: Public information on NMPA’s official website shows that this quadrivalent meningococcal conjugate vaccine, Manhaixin, independently developed by a Chinese company, has been included in the priority review by the Center for Drug Evaluation (CDE) of the State Food and Drug Administration of China, and is intended to be used for prevention Meningococcal meningitis caused by group A, group C, group Y and group W135 meningococcus .
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Cereb Cortex︱Li Qiang/Mingdong's research group jointly revealed the key white matter structural lesions in patients with mild cognitive impairment
Time of Update: 2022-01-24
On December 4, 2021, Tianjin University's School of Microelectronics and the Ministry of Medicine jointly published an article entitled "Hippocampus- and thalamus- related fiber-specific white matter reductions in mild cognitive impairment" on Cerebral Cortex, an important international journal of brain science.
