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Nearly a year after the COVID-19 outbreak, chronic long-term COVID syndrome is considered a separate disease in 2021
.
Long-term COVID patients exhibit dangerous neurological deficits that become persistent over time, resulting in disability
.
The pathogenesis of long-term COVID neurological syndrome is unclear and active research is needed to find solutions to long-term COVID
.
This article discusses possible causative factors such as viral load loci, differences in immune response, neurodegenerative changes, and inflammation to understand and study the pathogenesis of long-term COVID neurological syndrome
.
Prolonged COVID syndrome is a complex chronic clinical sign and symptom presentation in patients who have experienced SARS-CoV-2 infection but have not yet fully recovered
.
An increasing number of COVID-19 patients are suffering from the persistent effects of the disease, with symptoms including stupor, difficulty remembering recent events, tachycardia and extreme fatigue
.
Patients who did not develop prolonged COVID syndrome following infection with SARS-CoV-2 were reported to be asymptomatic within 8-12 weeks or less of infection
.
The extent to which the human immune system responds to COVID-19 varies from person to person for several reasons, including (a) viral load, (b) expression levels of ACE2 in tissues, and (c) the diversity of immune responses
.
It appears that after the acute phase, if clearance of SARS-CoV-2 is insufficient, subacute infection will persist and become chronic, eventually manifesting as a prolonged COVID syndrome
.
Vaccines may help some patients with long-term COVID-19, but this finding requires further study to verify whether vaccines can support patients with chronic long-term COVID-19 symptoms at the onset level
.
Stimulating a weakly primed immune system to destroy the virus also appears to be a possibility, but other mechanisms may also be at work, but this has not been elucidated in long-term COVID
.
Long-term COVID neurological deficits are predicted to impose a huge burden on the healthcare industry and are now recognized as a major cause of disability in the post-acute COVID patient population
.
Therefore, it is very necessary to conduct research on neurological dysfunction in long-term COVID patients to understand the basic pathogenesis of neuro-COVID
.
Clinical evaluation and an appropriate treatment plan are also necessary, as neurological deficits can progress to irreversible and permanent disability if left unchecked
.
Cite this paper Abdul Mannan Baig, Counting the neurological cost of COVID-19, Nature Reviews Neurology, 10.
1038/s41582-021-00593-7, (2021).
https://doi.
org/10.
1111/cns.
13737[Health Sciences ]Journal Introduction CNS Neuroscience & Therapeutics is an open access journal published by Wiley.
Once published, all papers can be freely read, downloaded and used worldwide
.
The journal focuses on research in neurological and psychiatric disorders such as stroke, Parkinson's disease, Alzheimer's disease, depression, schizophrenia, epilepsy and substance abuse
.
Provides a vehicle for the rapid publication of clinical, experimental and translational research papers, timely review and reporting of new discoveries related to CNS therapy, and methods for clinical pharmacology, drug development and new drug evaluation
.
The impact of CNS Neuroscience & Therapeutics in 2020 is ranked Neurosciences Q2, Pharmacology & Pharmacy Q1 because of 5.
243
.
Journal homepage: https://onlinelibrary.
wiley.
com/journal/17555949 Related reading CNS Neuroscience & Therapeutics 2020 Collection of Highly Cited Papers by Chinese Authors Congratulations to Wiley's OA medical journal CNS Neuroscience & Therapeutics for its new high impact factor! Neurological manifestations of COVID-19 and its significance|CNS Neuroscience&TherapeuticsCNS Neuroscience & Therapeutics|What are the most downloaded articles? Content | Proofreading by Amanda | Typesetting by Jiayi | Mingsong Wiley is a global leader in research and education, inspiring human potential by fostering discovery, empowering education and shaping talent
.
For more than 200 years, Wiley has driven the development of the global knowledge ecosystem
.
Today, our high-impact content, platforms and services help researchers, learners, institutions and businesses achieve their goals in a rapidly changing world
.
Wiley's global headquarters is located in Hoboken, New Jersey, USA, and the company is listed on the New York Stock Exchange under the symbols JWa and JWb
.
Like, watch, share, come to one-click three links!
.
Long-term COVID patients exhibit dangerous neurological deficits that become persistent over time, resulting in disability
.
The pathogenesis of long-term COVID neurological syndrome is unclear and active research is needed to find solutions to long-term COVID
.
This article discusses possible causative factors such as viral load loci, differences in immune response, neurodegenerative changes, and inflammation to understand and study the pathogenesis of long-term COVID neurological syndrome
.
Prolonged COVID syndrome is a complex chronic clinical sign and symptom presentation in patients who have experienced SARS-CoV-2 infection but have not yet fully recovered
.
An increasing number of COVID-19 patients are suffering from the persistent effects of the disease, with symptoms including stupor, difficulty remembering recent events, tachycardia and extreme fatigue
.
Patients who did not develop prolonged COVID syndrome following infection with SARS-CoV-2 were reported to be asymptomatic within 8-12 weeks or less of infection
.
The extent to which the human immune system responds to COVID-19 varies from person to person for several reasons, including (a) viral load, (b) expression levels of ACE2 in tissues, and (c) the diversity of immune responses
.
It appears that after the acute phase, if clearance of SARS-CoV-2 is insufficient, subacute infection will persist and become chronic, eventually manifesting as a prolonged COVID syndrome
.
Vaccines may help some patients with long-term COVID-19, but this finding requires further study to verify whether vaccines can support patients with chronic long-term COVID-19 symptoms at the onset level
.
Stimulating a weakly primed immune system to destroy the virus also appears to be a possibility, but other mechanisms may also be at work, but this has not been elucidated in long-term COVID
.
Long-term COVID neurological deficits are predicted to impose a huge burden on the healthcare industry and are now recognized as a major cause of disability in the post-acute COVID patient population
.
Therefore, it is very necessary to conduct research on neurological dysfunction in long-term COVID patients to understand the basic pathogenesis of neuro-COVID
.
Clinical evaluation and an appropriate treatment plan are also necessary, as neurological deficits can progress to irreversible and permanent disability if left unchecked
.
Cite this paper Abdul Mannan Baig, Counting the neurological cost of COVID-19, Nature Reviews Neurology, 10.
1038/s41582-021-00593-7, (2021).
https://doi.
org/10.
1111/cns.
13737[Health Sciences ]Journal Introduction CNS Neuroscience & Therapeutics is an open access journal published by Wiley.
Once published, all papers can be freely read, downloaded and used worldwide
.
The journal focuses on research in neurological and psychiatric disorders such as stroke, Parkinson's disease, Alzheimer's disease, depression, schizophrenia, epilepsy and substance abuse
.
Provides a vehicle for the rapid publication of clinical, experimental and translational research papers, timely review and reporting of new discoveries related to CNS therapy, and methods for clinical pharmacology, drug development and new drug evaluation
.
The impact of CNS Neuroscience & Therapeutics in 2020 is ranked Neurosciences Q2, Pharmacology & Pharmacy Q1 because of 5.
243
.
Journal homepage: https://onlinelibrary.
wiley.
com/journal/17555949 Related reading CNS Neuroscience & Therapeutics 2020 Collection of Highly Cited Papers by Chinese Authors Congratulations to Wiley's OA medical journal CNS Neuroscience & Therapeutics for its new high impact factor! Neurological manifestations of COVID-19 and its significance|CNS Neuroscience&TherapeuticsCNS Neuroscience & Therapeutics|What are the most downloaded articles? Content | Proofreading by Amanda | Typesetting by Jiayi | Mingsong Wiley is a global leader in research and education, inspiring human potential by fostering discovery, empowering education and shaping talent
.
For more than 200 years, Wiley has driven the development of the global knowledge ecosystem
.
Today, our high-impact content, platforms and services help researchers, learners, institutions and businesses achieve their goals in a rapidly changing world
.
Wiley's global headquarters is located in Hoboken, New Jersey, USA, and the company is listed on the New York Stock Exchange under the symbols JWa and JWb
.
Like, watch, share, come to one-click three links!
