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JAMA Network Open: Smoking and drinking linked to multiple sclerosis
Time of Update: 2022-05-23
published a research article in JAMA NETWORK OPEN entitled Associations of Alcohol Consumption and Smoking With Disease Risk and Neurodegeneration in Individuals With Multiple Sclerosis in the United Kingdom, exploring alcohol consumption, smoking, obesity and MS diagnosis and macular ganglion cell layer and the thickness of the inner plexiform layer (macular ganglion cell layer and inner plexiform layer, mGCIPL) .
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Alzheimer's & Dementia: Cerebrospinal fluid HDL particles predict Alzheimer's disease
Time of Update: 2022-05-22
Yassine et al hypothesized that small high-density lipoprotein (HDL) particles, through their ability to exchange lipids, affect neuronal membrane composition and vascular and synaptic function, thereby reducing the risk of Alzheimer's disease (AD) .
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JAHA: Platelet function linked to dementia risk
Time of Update: 2022-05-22
hypertensionCONCLUSIONS: At 20 years of follow-up, individuals with no antiplatelet therapy and higher platelet responses had a higher risk of dementia later in life, underscoring the role of platelet function in AD risk .
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Neurology: Large National Epidemiological Study Confirms Cancer Events Increase Risk of Guillain-Barre Syndrome!
Time of Update: 2022-05-22
We sought to conduct a large population-based nationwide study to assess the link between cancer and subsequent GBS development and examine the magnitude of the risk associated with organ-specific cancers .
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JAMA sub-journal: Maintenance IVIG is associated with significantly less recurrence of MOG-AD disease
Time of Update: 2022-05-22
Recent studies suggest that maintenance intravenous immunoglobulin (IVIG) may be an effective treatment for preventing recurrence of myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) ; Few studies have evaluated IVIG in adult patients .
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"The Lancet" sub-issue: A cohort study of centenarians in China shows that the prevalence of cognitive decline over the age of 80 has reached 76.6%!
Time of Update: 2022-05-22
Univariate logistic regression analysis showed that in centenarians and oldest adults, PNI was inversely associated with cognitive decline (P < 0.
Multivariate logistic analysis showed that centenarians were more likely to have lower MMSE, PNI and MNA-SF (P < 0·05 ; Supplementary Table 4) .
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Neurology: Trajectory comparison of key clinical characteristics of dementia patients diagnosed at autopsy: Dementia with Lewy bodies (DLB) patients deteriorate faster than Alzheimer's disease (AD) patients!
Time of Update: 2022-05-22
A study published in Neurology aimed to compare the trajectories of key clinical features, including cognition, function, and dependence, among three autopsy-confirmed groups: AD, AD+DLB, and DLB .
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Neuropsychopharmacology: Yang Yuanjian's team from Jiangxi Mental Health Center found that the longevity factor Klotho may have antidepressant potential
Time of Update: 2022-05-22
On April 21, 2022, Yang Yuanjian's research team from Jiangxi Provincial Mental Health Center and Nanchang Key Laboratory of Biological Psychiatry published an article in the journal Neuropsychopharmacology , a sub-journal of Nature, revealing that the anti-aging protein Klotho is reduced in expression in the brain after chronic stress and is involved in regulation Depressive-like behavior disorder .
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Neuroradiology: High-resolution vessel wall MR in brain bacterial/fungal infections
Time of Update: 2022-05-22
Axial (c) and sagittal (d) contrast-enhanced imaging of the vessel wall shows homogeneous enhancement of the basilar artery (thick arrows in c and d, inset in c) and cerebellar lobar leiomeningitis (thin arrows in c and d) :A 68-year-old man with a history of fungal sinusitis presented with altered mental status and bilateral paralysis .
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PLOS MED: Lithium use reduces risk of dementia and its subtypes
Time of Update: 2022-05-22
To assess the relationship between lithium use and the incidence of dementia and its subtypes, academics from Cambridge, UK conducted a retrospective cohort study comparing the period from 1 January 2005 to 31 December 2019 Data on treated patients and results were published in the journal PLOS MEDICINE .
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Astellas' gene therapy takes another hit
Time of Update: 2022-05-22
The company's gene therapy approach for DMD uses an AAV vector encoding a modified U7 snRNA to deliver an antisense sequence designed to induce cells to skip the erroneous or misplaced genetic code in the dystrophin gene, thereby restoring functional dystrophin Production of atrophin .
AT702 is an AAV antisense gene therapy designed for DMD patients with exon 2 skipping .
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AJNR: MR features of the carotid artery wall in restenosis after CEA can help inform next-step treatment decisions
Time of Update: 2022-05-22
Pre-enhanced VWMRI (B) of the proximal ICA (straight line in A) shows concentric homogeneous thickening of the vessel wall (long arrows), suggesting MH .
Pre-enhanced VWMRI (B) of the proximal ICA (straight line in A) shows concentric homogeneous thickening of the vessel wall (long arrows), suggesting MH .
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J Neuroinflam: An Jing/Luan Guoming teamwork reveals a new pathogenesis of Rasmussen encephalitis
Time of Update: 2022-05-22
Rasmussen 's encephalitis ( RE ) is a chronic neurological disease of unknown etiology seen in children [1], with an average age of onset of 6 years . The disease is extremely rare . In Europe, th
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Alzheimer's & Dementia: Reducing Air Pollution, Preventing Dementia
Time of Update: 2022-05-22
Exposure to air pollution increases the risk of dementia, and important pollutant effects may precede dementia onset by years, if not decades .
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npj Parkinsons Dis: Degree of constipation that predicts clinical outcomes in Parkinson's patients
Time of Update: 2022-05-22
After adjusting for relevant confounders, Cox regression analysis confirmed a significant association between constipation severity and dementia progression, but not postural instability or death .
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Stroke: Trajectories of systolic blood pressure and patient outcomes in acute intracerebral hemorrhage
Time of Update: 2022-05-22
CONCLUSIONS: Data observations using a group-based trajectory modeling approach may help to elucidate the relationship between antihypertensive treatment, trends in SBP, and acute intracerebral hemorrhage outcomes .
Data observations using a group-based trajectory modeling approach may help elucidate the relationship between antihypertensive treatment, SBP trends, and acute intracerebral hemorrhage outcomes .
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Nat Commun: Scientists discover potential therapeutic target for Alzheimer's disease!
Time of Update: 2022-05-22
Since the hippocampus is a key site of AD dysfunction, could SCDi improve hippocampal function?immune immune stem cellsRecently, researchers from the University of Sherbrooke published a research paper titled "Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer's disease mouse model" on Nat Commun, studying stearoyl-CoA The role of desaturase (SCD), a key regulator of fatty acid desaturation, in AD pathogenesis .
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JNNP: The effect of gender on disease development in patients with multiple sclerosis
Time of Update: 2022-05-22
Changes in relapse rates and Extended Disability Status Scale (EDSS) scores were analyzed using weighted general linear models, and HRs between men and women with different EDSS endpoints were analyzed using weighted Cox regression The weighted estimated marginal mean of the annualized recurrence rate and the ratio of male to female recurrence rates for patients still on treatment by sex The first part of the study was a cohort follow-up study .
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The team of Professor Jiang Jihui from Shanghai University has made important progress in the field of Alzheimer's disease medical imaging research
Time of Update: 2022-05-08
The study selected a large sample of MPMRI data from Xuanwu Hospital and ADNI cohort, extracted MPMRI features of 7 brain networks and 90 regions of interest, and performed a machine learning method based on support vector machine (SVM) on SCD and normal control group (NC).
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Alzheimer & Dementia: In addition to Aβ and tau, these plasma proteins are also associated with cognitive decline and dementia risk!
Time of Update: 2022-05-08
To this end, experts from the Department of Epidemiology and Public Health at UCL, UK, examined the association between 4,953 plasma proteins and the risk of cognitive decline and dementia in two cohort studies followed for 20 years.
