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Alzheimer & Dementia: In addition to Aβ and tau, these plasma proteins are also associated with cognitive decline and dementia risk!

 Last Update: 2022-05-08
 Source: Internet
 Author: User

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Alzheimer's disease (AD) and related dementias pose a growing challenge, imposing enormous costs on personal, health and social care services

Furthermore, longitudinal studies have shown that most cognitively normal Aβ-positive individuals never develop clinical dementia

The causes of dementia are increasingly recognized as systemic

In the Whitehall II prospective cohort study, proteins were measured using the SOMAscan technique

The results showed that 15 non-Aβ/non-tau-related proteins were associated with cognitive decline and dementia, were consistently identified in both cohorts, and were not explained by known dementia risk factors

The levels of six of these proteins can be modulated by drugs currently approved to treat other diseases

This study identified several plasma proteins associated with cognitive decline and long-term risk of dementia in people without dementia

references:

Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies.

Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies.
https://doi.
org/10.
1002/alz.
12419 Plasma proteins, cognitive decline, and 20-year risk of dementia in the Whitehall II and Atherosclerosis Risk in Communities studies.
https://doi.
org/10.
1002/alz.
12419

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